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Anti-PERM/ MPO functional antibody
Anti-PERM/ MPO functional antibody for cell culture, ELISA & in-vivo assay
Go to MPO/MPO products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T23471-Ab-1/ GM-Tg-hg-T23471-Ab-2 | Anti-Human MPO monoclonal antibody | Human |
| GM-Tg-rg-T23471-Ab-1/ GM-Tg-rg-T23471-Ab-2 | Anti-Rat MPO monoclonal antibody | Rat |
| GM-Tg-mg-T23471-Ab-1/ GM-Tg-mg-T23471-Ab-2 | Anti-Mouse MPO monoclonal antibody | Mouse |
| GM-Tg-cynog-T23471-Ab-1/ GM-Tg-cynog-T23471-Ab-2 | Anti-Cynomolgus/ Rhesus macaque MPO monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T23471-Ab-1/ GM-Tg-felg-T23471-Ab-2 | Anti-Feline MPO monoclonal antibody | Feline |
| GM-Tg-cang-T23471-Ab-1/ GM-Tg-cang-T23471-Ab-2 | Anti-Canine MPO monoclonal antibody | Canine |
| GM-Tg-bovg-T23471-Ab-1/ GM-Tg-bovg-T23471-Ab-2 | Anti-Bovine MPO monoclonal antibody | Bovine |
| GM-Tg-equg-T23471-Ab-1/ GM-Tg-equg-T23471-Ab-2 | Anti-Equine MPO monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T23471-Ab-1/ GM-Tg-hg-T23471-Ab-2; GM-Tg-rg-T23471-Ab-1/ GM-Tg-rg-T23471-Ab-2; GM-Tg-mg-T23471-Ab-1/ GM-Tg-mg-T23471-Ab-2; GM-Tg-cynog-T23471-Ab-1/ GM-Tg-cynog-T23471-Ab-2; GM-Tg-felg-T23471-Ab-1/ GM-Tg-felg-T23471-Ab-2; GM-Tg-cang-T23471-Ab-1/ GM-Tg-cang-T23471-Ab-2; GM-Tg-bovg-T23471-Ab-1/ GM-Tg-bovg-T23471-Ab-2; GM-Tg-equg-T23471-Ab-1/ GM-Tg-equg-T23471-Ab-2 |
| Products Name | Anti-MPO monoclonal antibody |
| Format | mab |
| Target Name | MPO |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody, Diagnostic target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-MPO benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T23471-Ag-1 | Recombinant multi-species PERM/ MPO protein |
Target information
| Target ID | GM-T23471 |
| Target Name | MPO |
| Gene ID | 4353,17523,303413,714246,609986,100142673,511206,100070920 |
| Gene Symbol and Synonyms | mKIAA4033,MPO |
| Uniprot Accession | P05164 |
| Uniprot Entry Name | PERM_HUMAN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | Therapeutics Target, Diagnostics Biomarker |
| Disease | Ovary Cancer, prolonged cough, Eosinophilic airway inflammation, lung function assessment, Asthma, Congenital occlusion of ureteropelvic junction, Dent disease, Cardiovascular disease, Cystic fibrosis |
| Gene Ensembl | ENSG00000005381 |
| Target Classification | N/A |
The target: MPO, gene name: MPO, also named as . Myeloperoxidase (MPO) is a heme protein synthesized during myeloid differentiation that constitutes the major component of neutrophil azurophilic granules. Produced as a single chain precursor, myeloperoxidase is subsequently cleaved into a light and heavy chain. The mature myeloperoxidase is a tetramer composed of 2 light chains and 2 heavy chains. This enzyme produces hypohalous acids central to the microbicidal activity of neutrophils. [provided by RefSeq, Nov 2014].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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