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Anti-AHR monoclonal antibody
Pre-made anti-AHR monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to AHR/AHR products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T23666-Ab-1/ GM-Tg-hg-T23666-Ab-2 | Anti-Human AHR monoclonal antibody | Human |
| GM-Tg-rg-T23666-Ab-1/ GM-Tg-rg-T23666-Ab-2 | Anti-Rat AHR monoclonal antibody | Rat |
| GM-Tg-mg-T23666-Ab-1/ GM-Tg-mg-T23666-Ab-2 | Anti-Mouse AHR monoclonal antibody | Mouse |
| GM-Tg-cynog-T23666-Ab-1/ GM-Tg-cynog-T23666-Ab-2 | Anti-Cynomolgus/ Rhesus macaque AHR monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T23666-Ab-1/ GM-Tg-felg-T23666-Ab-2 | Anti-Feline AHR monoclonal antibody | Feline |
| GM-Tg-cang-T23666-Ab-1/ GM-Tg-cang-T23666-Ab-2 | Anti-Canine AHR monoclonal antibody | Canine |
| GM-Tg-bovg-T23666-Ab-1/ GM-Tg-bovg-T23666-Ab-2 | Anti-Bovine AHR monoclonal antibody | Bovine |
| GM-Tg-equg-T23666-Ab-1/ GM-Tg-equg-T23666-Ab-2 | Anti-Equine AHR monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T23666-Ab-1/ GM-Tg-hg-T23666-Ab-2; GM-Tg-rg-T23666-Ab-1/ GM-Tg-rg-T23666-Ab-2; GM-Tg-mg-T23666-Ab-1/ GM-Tg-mg-T23666-Ab-2; GM-Tg-cynog-T23666-Ab-1/ GM-Tg-cynog-T23666-Ab-2; GM-Tg-felg-T23666-Ab-1/ GM-Tg-felg-T23666-Ab-2; GM-Tg-cang-T23666-Ab-1/ GM-Tg-cang-T23666-Ab-2; GM-Tg-bovg-T23666-Ab-1/ GM-Tg-bovg-T23666-Ab-2; GM-Tg-equg-T23666-Ab-1/ GM-Tg-equg-T23666-Ab-2 |
| Products Name | Anti-AHR monoclonal antibody |
| Format | mab |
| Target Name | AHR |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-AHR monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T23666-Ag-1 | Recombinant multi-species AHR/ bHLHe76 protein |
| ORF Viral Vector | vGMAD000437 | human AHR Adenovirus particle |
| ORF Viral Vector | vGMAD000126 | human AHR Adenovirus particle |
| ORF Viral Vector | pGMAD000126 | human AHR Adenovirus plasmid |
| ORF Viral Vector | pGMAD000437 | human AHR Adenovirus plasmid |
| ORF Viral Vector | pGMAD000257 | mouse Ahr Adenovirus plasmid |
| ORF Viral Vector | vGMAD000257 | mouse Ahr Adenovirus particle |
Target information
| Target ID | GM-T23666 |
| Target Name | AHR |
| Gene ID | 196,11622,25690,714254,475251,101084947,280714,100066186 |
| Gene Symbol and Synonyms | Ah,Ahh,AHR,Ahre,bHLHe76,In,RP85 |
| Uniprot Accession | P35869,P41738 |
| Uniprot Entry Name | AHR_HUMAN,AHR_RAT |
| Protein Sub-location | Introcelluar Protein |
| Category | Therapeutics Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000106546 |
| Target Classification | N/A |
The target: AHR, gene name: AHR, also named as bHLHe76. The protein encoded by this gene is a ligand-activated helix-loop-helix transcription factor involved in the regulation of biological responses to planar aromatic hydrocarbons. This receptor has been shown to regulate xenobiotic-metabolizing enzymes such as cytochrome P450. Before ligand binding, the encoded protein is sequestered in the cytoplasm; upon ligand binding, this protein moves to the nucleus and stimulates transcription of target genes. [provided by RefSeq, Sep 2015].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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