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Anti-MGMT monoclonal antibody
Pre-made anti-MGMT monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to MGMT/MGMT products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T24587-Ab-1/ GM-Tg-hg-T24587-Ab-2 | Anti-Human MGMT monoclonal antibody | Human |
| GM-Tg-rg-T24587-Ab-1/ GM-Tg-rg-T24587-Ab-2 | Anti-Rat MGMT monoclonal antibody | Rat |
| GM-Tg-mg-T24587-Ab-1/ GM-Tg-mg-T24587-Ab-2 | Anti-Mouse MGMT monoclonal antibody | Mouse |
| GM-Tg-cynog-T24587-Ab-1/ GM-Tg-cynog-T24587-Ab-2 | Anti-Cynomolgus/ Rhesus macaque MGMT monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T24587-Ab-1/ GM-Tg-felg-T24587-Ab-2 | Anti-Feline MGMT monoclonal antibody | Feline |
| GM-Tg-cang-T24587-Ab-1/ GM-Tg-cang-T24587-Ab-2 | Anti-Canine MGMT monoclonal antibody | Canine |
| GM-Tg-bovg-T24587-Ab-1/ GM-Tg-bovg-T24587-Ab-2 | Anti-Bovine MGMT monoclonal antibody | Bovine |
| GM-Tg-equg-T24587-Ab-1/ GM-Tg-equg-T24587-Ab-2 | Anti-Equine MGMT monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T24587-Ab-1/ GM-Tg-hg-T24587-Ab-2; GM-Tg-rg-T24587-Ab-1/ GM-Tg-rg-T24587-Ab-2; GM-Tg-mg-T24587-Ab-1/ GM-Tg-mg-T24587-Ab-2; GM-Tg-cynog-T24587-Ab-1/ GM-Tg-cynog-T24587-Ab-2; GM-Tg-felg-T24587-Ab-1/ GM-Tg-felg-T24587-Ab-2; GM-Tg-cang-T24587-Ab-1/ GM-Tg-cang-T24587-Ab-2; GM-Tg-bovg-T24587-Ab-1/ GM-Tg-bovg-T24587-Ab-2; GM-Tg-equg-T24587-Ab-1/ GM-Tg-equg-T24587-Ab-2 |
| Products Name | Anti-MGMT monoclonal antibody |
| Format | mab |
| Target Name | MGMT |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-MGMT monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T24587-Ag-1 | Recombinant multi-species MGMT protein |
| ORF Viral Vector | pGMLP004946 | human Mgmt Lentivirus plasmid |
| ORF Viral Vector | vGMLV000629 | human MGMT Lentivirus particle |
| ORF Viral Vector | vGMLP004946 | human Mgmt Lentivirus particle |
| ORF Viral Vector | pGMLV000629 | human MGMT Lentivirus plasmid |
| ORF Viral Vector | pGMLPm000491 | mouse Mgmt Lentivirus plasmid |
| ORF Viral Vector | vGMLPm000491 | mouse Mgmt Lentivirus particle |
Target information
| Target ID | GM-T24587 |
| Target Name | MGMT |
| Gene ID | 4255,17314,25332,698134,442978,101085076,616091,100049801 |
| Gene Symbol and Synonyms | Agat,AGT,MGMT |
| Uniprot Accession | P16455,P24528,Q6TDU1,P29177 |
| Uniprot Entry Name | MGMT_HUMAN,MGMT_RAT,MGMT_CANLF,MGMT_BOVIN |
| Protein Sub-location | Introcelluar Protein |
| Category | Therapeutics Target |
| Disease | Lung Cancer |
| Gene Ensembl | ENSG00000170430 |
| Target Classification | N/A |
The target: MGMT, gene name: MGMT, also named as . Alkylating agents are potent carcinogens that can result in cell death, mutation and cancer. The protein encoded by this gene is a DNA repair protein that is involved in cellular defense against mutagenesis and toxicity from alkylating agents. The protein catalyzes transfer of methyl groups from O(6)-alkylguanine and other methylated moieties of the DNA to its own molecule, which repairs the toxic lesions. Methylation of the genes promoter has been associated with several cancer types, including colorectal cancer, lung cancer, lymphoma and glioblastoma. [provided by RefSeq, Sep 2015].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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