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Anti-BCL11A monoclonal antibody
Pre-made anti-BCL11A monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to BCL11A/BCL11A products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T26470-Ab-1/ GM-Tg-hg-T26470-Ab-2 | Anti-Human BCL11A monoclonal antibody | Human |
| GM-Tg-rg-T26470-Ab-1/ GM-Tg-rg-T26470-Ab-2 | Anti-Rat BCL11A monoclonal antibody | Rat |
| GM-Tg-mg-T26470-Ab-1/ GM-Tg-mg-T26470-Ab-2 | Anti-Mouse BCL11A monoclonal antibody | Mouse |
| GM-Tg-cynog-T26470-Ab-1/ GM-Tg-cynog-T26470-Ab-2 | Anti-Cynomolgus/ Rhesus macaque BCL11A monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T26470-Ab-1/ GM-Tg-felg-T26470-Ab-2 | Anti-Feline BCL11A monoclonal antibody | Feline |
| GM-Tg-cang-T26470-Ab-1/ GM-Tg-cang-T26470-Ab-2 | Anti-Canine BCL11A monoclonal antibody | Canine |
| GM-Tg-bovg-T26470-Ab-1/ GM-Tg-bovg-T26470-Ab-2 | Anti-Bovine BCL11A monoclonal antibody | Bovine |
| GM-Tg-equg-T26470-Ab-1/ GM-Tg-equg-T26470-Ab-2 | Anti-Equine BCL11A monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T26470-Ab-1/ GM-Tg-hg-T26470-Ab-2; GM-Tg-rg-T26470-Ab-1/ GM-Tg-rg-T26470-Ab-2; GM-Tg-mg-T26470-Ab-1/ GM-Tg-mg-T26470-Ab-2; GM-Tg-cynog-T26470-Ab-1/ GM-Tg-cynog-T26470-Ab-2; GM-Tg-felg-T26470-Ab-1/ GM-Tg-felg-T26470-Ab-2; GM-Tg-cang-T26470-Ab-1/ GM-Tg-cang-T26470-Ab-2; GM-Tg-bovg-T26470-Ab-1/ GM-Tg-bovg-T26470-Ab-2; GM-Tg-equg-T26470-Ab-1/ GM-Tg-equg-T26470-Ab-2 |
| Products Name | Anti-BCL11A monoclonal antibody |
| Format | mab |
| Target Name | BCL11A |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-BCL11A monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T26470-Ag-1 | Recombinant multi-species BC11A/ BCL11A/ BCL11A-L-S protein |
Target information
| Target ID | GM-T26470 |
| Target Name | BCL11A |
| Gene ID | 53335,14025,305589,717675,481381,101098704,538680,100065364 |
| Gene Symbol and Synonyms | 2810047E18Rik,BCL-11A,BCL11A,CTIP1,D930021L15Rik,DILOS,EVI9,Evi9a,Evi9b,Evi9c,HBFQTL5,mKIAA1809,SMARCM1,ZNF856 |
| Uniprot Accession | Q9H165 |
| Uniprot Entry Name | BC11A_HUMAN |
| Protein Sub-location | Introcelluar Protein |
| Category | Therapeutics Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000119866 |
| Target Classification | N/A |
The target: BCL11A, gene name: BCL11A, also named as BCL11A-L-S, BCL11A-XL, BCL11a-M, CTIP1, DILOS, EVI9, HBFQTL5, ZNF856, BCL11A. This gene encodes a C2H2 type zinc-finger protein by its similarity to the mouse Bcl11a/Evi9 protein. The corresponding mouse gene is a common site of retroviral integration in myeloid leukemia, and may function as a leukemia disease gene, in part, through its interaction with BCL6. During hematopoietic cell differentiation, this gene is down-regulated. It is possibly involved in lymphoma pathogenesis since translocations associated with B-cell malignancies also deregulates its expression. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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