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Anti-KDM5A monoclonal antibody
Pre-made anti-KDM5A monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to KDM5A/KDM5A products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T28052-Ab-1/ GM-Tg-hg-T28052-Ab-2 | Anti-Human KDM5A monoclonal antibody | Human |
| GM-Tg-rg-T28052-Ab-1/ GM-Tg-rg-T28052-Ab-2 | Anti-Rat KDM5A monoclonal antibody | Rat |
| GM-Tg-mg-T28052-Ab-1/ GM-Tg-mg-T28052-Ab-2 | Anti-Mouse KDM5A monoclonal antibody | Mouse |
| GM-Tg-cynog-T28052-Ab-1/ GM-Tg-cynog-T28052-Ab-2 | Anti-Cynomolgus/ Rhesus macaque KDM5A monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T28052-Ab-1/ GM-Tg-felg-T28052-Ab-2 | Anti-Feline KDM5A monoclonal antibody | Feline |
| GM-Tg-cang-T28052-Ab-1/ GM-Tg-cang-T28052-Ab-2 | Anti-Canine KDM5A monoclonal antibody | Canine |
| GM-Tg-bovg-T28052-Ab-1/ GM-Tg-bovg-T28052-Ab-2 | Anti-Bovine KDM5A monoclonal antibody | Bovine |
| GM-Tg-equg-T28052-Ab-1/ GM-Tg-equg-T28052-Ab-2 | Anti-Equine KDM5A monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T28052-Ab-1/ GM-Tg-hg-T28052-Ab-2; GM-Tg-rg-T28052-Ab-1/ GM-Tg-rg-T28052-Ab-2; GM-Tg-mg-T28052-Ab-1/ GM-Tg-mg-T28052-Ab-2; GM-Tg-cynog-T28052-Ab-1/ GM-Tg-cynog-T28052-Ab-2; GM-Tg-felg-T28052-Ab-1/ GM-Tg-felg-T28052-Ab-2; GM-Tg-cang-T28052-Ab-1/ GM-Tg-cang-T28052-Ab-2; GM-Tg-bovg-T28052-Ab-1/ GM-Tg-bovg-T28052-Ab-2; GM-Tg-equg-T28052-Ab-1/ GM-Tg-equg-T28052-Ab-2 |
| Products Name | Anti-KDM5A monoclonal antibody |
| Format | mab |
| Target Name | KDM5A |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-KDM5A monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T28052-Ag-1 | Recombinant multi-species KDM5A/ RBBP-2/ RBBP2 protein |
| ORF Viral Vector | pGMAD000038 | human KDM5A Adenovirus plasmid |
| ORF Viral Vector | vGMAD000038 | human KDM5A Adenovirus particle |
Target information
| Target ID | GM-T28052 |
| Target Name | KDM5A |
| Gene ID | 5927,214899,312678,721599,477727,101087846,507962,100056935 |
| Gene Symbol and Synonyms | Jarid1a,KDM5A,RBBP-2,RBBP2,RBP2 |
| Uniprot Accession | P29375 |
| Uniprot Entry Name | KDM5A_HUMAN |
| Protein Sub-location | Introcelluar Protein |
| Category | Therapeutics Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000073614 |
| Target Classification | N/A |
The target: KDM5A, gene name: KDM5A, also named as RBBP-2, RBBP2, RBP2. This gene encodes a member of the Jumonji, AT-rich interactive domain 1 (JARID1) histone demethylase protein family. The encoded protein plays a role in gene regulation through the histone code by specifically demethylating lysine 4 of histone H3. The encoded protein interacts with many other proteins, including retinoblastoma protein, and is implicated in the transcriptional regulation of Hox genes and cytokines. This gene may play a role in tumor progression. [provided by RefSeq, Aug 2013].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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