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Anti-LIF/ CDF/ DIA functional antibody
Anti-LIF/ CDF/ DIA functional antibody for cell culture, ELISA & in-vivo assay
Go to LIF/LIF products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T29774-Ab-1/ GM-Tg-hg-T29774-Ab-2 | Anti-Human LIF monoclonal antibody | Human |
| GM-Tg-rg-T29774-Ab-1/ GM-Tg-rg-T29774-Ab-2 | Anti-Rat LIF monoclonal antibody | Rat |
| GM-Tg-mg-T29774-Ab-1/ GM-Tg-mg-T29774-Ab-2 | Anti-Mouse LIF monoclonal antibody | Mouse |
| GM-Tg-cynog-T29774-Ab-1/ GM-Tg-cynog-T29774-Ab-2 | Anti-Cynomolgus/ Rhesus macaque LIF monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T29774-Ab-1/ GM-Tg-felg-T29774-Ab-2 | Anti-Feline LIF monoclonal antibody | Feline |
| GM-Tg-cang-T29774-Ab-1/ GM-Tg-cang-T29774-Ab-2 | Anti-Canine LIF monoclonal antibody | Canine |
| GM-Tg-bovg-T29774-Ab-1/ GM-Tg-bovg-T29774-Ab-2 | Anti-Bovine LIF monoclonal antibody | Bovine |
| GM-Tg-equg-T29774-Ab-1/ GM-Tg-equg-T29774-Ab-2 | Anti-Equine LIF monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T29774-Ab-1/ GM-Tg-hg-T29774-Ab-2; GM-Tg-rg-T29774-Ab-1/ GM-Tg-rg-T29774-Ab-2; GM-Tg-mg-T29774-Ab-1/ GM-Tg-mg-T29774-Ab-2; GM-Tg-cynog-T29774-Ab-1/ GM-Tg-cynog-T29774-Ab-2; GM-Tg-felg-T29774-Ab-1/ GM-Tg-felg-T29774-Ab-2; GM-Tg-cang-T29774-Ab-1/ GM-Tg-cang-T29774-Ab-2; GM-Tg-bovg-T29774-Ab-1/ GM-Tg-bovg-T29774-Ab-2; GM-Tg-equg-T29774-Ab-1/ GM-Tg-equg-T29774-Ab-2 |
| Products Name | Anti-LIF monoclonal antibody |
| Format | mab |
| Target Name | LIF |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-LIF benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T29774-Ag-1 | Recombinant multi-species LIF/ CDF/ DIA protein |
| Cytokine | GM-Tg-g-T29774-Ag-1 | leukemia inhibitory factor (LIF) protein |
| ORF Viral Vector | pGMLP000884 | human LIF Lentivirus plasmid |
| ORF Viral Vector | vGMLP000884 | human LIF Lentivirus particle |
| ORF Viral Vector | pGMLPm000487 | mouse Lif Lentivirus plasmid |
| ORF Viral Vector | vGMLPm000487 | mouse Lif Lentivirus particle |
Target information
| Target ID | GM-T29774 |
| Target Name | LIF |
| Gene ID | 3976,16878,60584,715456,403449,101090296,280840,100629131 |
| Gene Symbol and Synonyms | CDF,DIA,HILDA,LIF,MLPLI |
| Uniprot Accession | P15018,P17777,Q27956 |
| Uniprot Entry Name | LIF_HUMAN,LIF_RAT,LIF_BOVIN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | Therapeutics Target, Cytokine Target |
| Disease | Cancer |
| Gene Ensembl | ENSG00000128342 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: LIF, gene name: LIF, also named as CDF, DIA, HILDA, MLPLI. The protein encoded by this gene is a pleiotropic cytokine with roles in several different systems. It is involved in the induction of hematopoietic differentiation in normal and myeloid leukemia cells, induction of neuronal cell differentiation, regulator of mesenchymal to epithelial conversion during kidney development, and may also have a role in immune tolerance at the maternal-fetal interface. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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