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Anti-CXL10/ CXCL10/ C7 functional antibody
Anti-CXL10/ CXCL10/ C7 functional antibody for cell culture, ELISA & in-vivo assay
Go to CXCL10/CXCL10 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T30635-Ab-1/ GM-Tg-hg-T30635-Ab-2 | Anti-Human CXCL10 monoclonal antibody | Human |
| GM-Tg-rg-T30635-Ab-1/ GM-Tg-rg-T30635-Ab-2 | Anti-Rat CXCL10 monoclonal antibody | Rat |
| GM-Tg-mg-T30635-Ab-1/ GM-Tg-mg-T30635-Ab-2 | Anti-Mouse CXCL10 monoclonal antibody | Mouse |
| GM-Tg-cynog-T30635-Ab-1/ GM-Tg-cynog-T30635-Ab-2 | Anti-Cynomolgus/ Rhesus macaque CXCL10 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T30635-Ab-1/ GM-Tg-felg-T30635-Ab-2 | Anti-Feline CXCL10 monoclonal antibody | Feline |
| GM-Tg-cang-T30635-Ab-1/ GM-Tg-cang-T30635-Ab-2 | Anti-Canine CXCL10 monoclonal antibody | Canine |
| GM-Tg-bovg-T30635-Ab-1/ GM-Tg-bovg-T30635-Ab-2 | Anti-Bovine CXCL10 monoclonal antibody | Bovine |
| GM-Tg-equg-T30635-Ab-1/ GM-Tg-equg-T30635-Ab-2 | Anti-Equine CXCL10 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T30635-Ab-1/ GM-Tg-hg-T30635-Ab-2; GM-Tg-rg-T30635-Ab-1/ GM-Tg-rg-T30635-Ab-2; GM-Tg-mg-T30635-Ab-1/ GM-Tg-mg-T30635-Ab-2; GM-Tg-cynog-T30635-Ab-1/ GM-Tg-cynog-T30635-Ab-2; GM-Tg-felg-T30635-Ab-1/ GM-Tg-felg-T30635-Ab-2; GM-Tg-cang-T30635-Ab-1/ GM-Tg-cang-T30635-Ab-2; GM-Tg-bovg-T30635-Ab-1/ GM-Tg-bovg-T30635-Ab-2; GM-Tg-equg-T30635-Ab-1/ GM-Tg-equg-T30635-Ab-2 |
| Products Name | Anti-CXCL10 monoclonal antibody |
| Format | mab |
| Target Name | CXCL10 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-CXCL10 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Biosimilar | GMP-Bios-ab-168 | Pre-Made Eldelumab biosimilar, Whole mAb, Anti-CXCL10 Antibody: Anti-C7/IFI10/INP10/IP-10/SCYB10/crg-2/gIP-10/mob-1 therapeutic antibody |
| Target Antigen | GM-Tg-g-T30635-Ag-1 | Recombinant multi-species CXL10/ CXCL10/ C7 protein |
| Cytokine | GM-Tg-g-T30635-Ag-1 | chemokine (C-X-C motif) ligand 10 (CXCL10) protein |
| ORF Viral Vector | pGMAP000053 | Human CXCL10 Adenovirus plasmid |
| ORF Viral Vector | vGMAP000053 | Human CXCL10 Adenovirus particle |
| ORF Viral Vector | pGMLP001931 | human CXCL10 Lentivirus plasmid |
| ORF Viral Vector | vGMLP001931 | human CXCL10 Lentivirus particle |
| ORF Viral Vector | pGMLPm000068 | mouse Cxcl10 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm000068 | mouse Cxcl10 Lentivirus particle |
Target information
| Target ID | GM-T30635 |
| Target Name | CXCL10 |
| Gene ID | 3627,245920,574243,478432,101100131,615107,100050993 |
| Gene Symbol and Synonyms | C7,crg-2,CXCL10,gIP-10,IFI10,INP10,IP-10,mob-1,SCYB10 |
| Uniprot Accession | P02778,P48973,Q8MIZ1,Q5KSV9,Q2KIQ8 |
| Uniprot Entry Name | CXL10_HUMAN,CXL10_MACMU,CXL10_RAT,CXL10_CANLF,CXL10_BOVIN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | Therapeutics Target, INN Index, Cytokine Target |
| Disease | Breast Cancer, Complications of kidney transplant, Bacterial sepsis of newborn, Acute kidney failure |
| Gene Ensembl | ENSG00000169245 |
| Target Classification | N/A |
The target: CXCL10, gene name: CXCL10, also named as C7, IFI10, INP10, IP-10, SCYB10, crg-2, gIP-10, mob-1. This antimicrobial gene encodes a chemokine of the CXC subfamily and ligand for the receptor CXCR3. Binding of this protein to CXCR3 results in pleiotropic effects, including stimulation of monocytes, natural killer and T-cell migration, and modulation of adhesion molecule expression. This gene may also be a key regulator of the 'cytokine storm' immune response to SARS-CoV-2 infection. [provided by RefSeq, Sep 2020].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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