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Anti-LIRB4/ LILRB4/ CD85K monoclonal antibody
Anti-LIRB4/ LILRB4/ CD85K antibody for FACS & in-vivo assay
Go to LILRB4/LILRB4 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T30846-Ab-1/ GM-Tg-hg-T30846-Ab-2 | Anti-Human LILRB4 monoclonal antibody | Human |
| GM-Tg-rg-T30846-Ab-1/ GM-Tg-rg-T30846-Ab-2 | Anti-Rat LILRB4 monoclonal antibody | Rat |
| GM-Tg-mg-T30846-Ab-1/ GM-Tg-mg-T30846-Ab-2 | Anti-Mouse LILRB4 monoclonal antibody | Mouse |
| GM-Tg-cynog-T30846-Ab-1/ GM-Tg-cynog-T30846-Ab-2 | Anti-Cynomolgus/ Rhesus macaque LILRB4 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T30846-Ab-1/ GM-Tg-felg-T30846-Ab-2 | Anti-Feline LILRB4 monoclonal antibody | Feline |
| GM-Tg-cang-T30846-Ab-1/ GM-Tg-cang-T30846-Ab-2 | Anti-Canine LILRB4 monoclonal antibody | Canine |
| GM-Tg-bovg-T30846-Ab-1/ GM-Tg-bovg-T30846-Ab-2 | Anti-Bovine LILRB4 monoclonal antibody | Bovine |
| GM-Tg-equg-T30846-Ab-1/ GM-Tg-equg-T30846-Ab-2 | Anti-Equine LILRB4 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T30846-Ab-1/ GM-Tg-hg-T30846-Ab-2; GM-Tg-rg-T30846-Ab-1/ GM-Tg-rg-T30846-Ab-2; GM-Tg-mg-T30846-Ab-1/ GM-Tg-mg-T30846-Ab-2; GM-Tg-cynog-T30846-Ab-1/ GM-Tg-cynog-T30846-Ab-2; GM-Tg-felg-T30846-Ab-1/ GM-Tg-felg-T30846-Ab-2; GM-Tg-cang-T30846-Ab-1/ GM-Tg-cang-T30846-Ab-2; GM-Tg-bovg-T30846-Ab-1/ GM-Tg-bovg-T30846-Ab-2; GM-Tg-equg-T30846-Ab-1/ GM-Tg-equg-T30846-Ab-2 |
| Products Name | Anti-LILRB4 monoclonal antibody |
| Format | mab |
| Target Name | LILRB4 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-LILRB4 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species LIRB4/ LILRB4/ CD85K VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | pGMLPm003473 | mouse Lilrb4a Lentivirus plasmid |
| ORF Viral Vector | pGMLPm005392 | mouse Lilrb4a Lentivirus plasmid |
| ORF Viral Vector | vGMLPm003473 | mouse Lilrb4a Lentivirus particle |
| ORF Viral Vector | vGMLPm005392 | mouse Lilrb4a Lentivirus particle |
Target information
| Target ID | GM-T30846 |
| Target Name | LILRB4 |
| Gene ID | 11006,692336 |
| Gene Symbol and Synonyms | B4,CD85K,ILT-3,ILT3,LILRB4,LILRBC,LIR-5,LIR5 |
| Uniprot Accession | Q8NHJ6 |
| Uniprot Entry Name | LIRB4_HUMAN |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000186818 |
| Target Classification | N/A |
The target: LILRB4, gene name: LILRB4, also named as CD85K, ILT-3, ILT3, LIR-5, LIR5. This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. The receptor can also function in antigen capture and presentation. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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