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Anti-LYAG/ GAA monoclonal antibody
Anti-LYAG/ GAA antibody for FACS & in-vivo assay
Go to GAA/GAA products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T31514-Ab-1/ GM-Tg-hg-T31514-Ab-2 | Anti-Human GAA monoclonal antibody | Human |
| GM-Tg-rg-T31514-Ab-1/ GM-Tg-rg-T31514-Ab-2 | Anti-Rat GAA monoclonal antibody | Rat |
| GM-Tg-mg-T31514-Ab-1/ GM-Tg-mg-T31514-Ab-2 | Anti-Mouse GAA monoclonal antibody | Mouse |
| GM-Tg-cynog-T31514-Ab-1/ GM-Tg-cynog-T31514-Ab-2 | Anti-Cynomolgus/ Rhesus macaque GAA monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T31514-Ab-1/ GM-Tg-felg-T31514-Ab-2 | Anti-Feline GAA monoclonal antibody | Feline |
| GM-Tg-cang-T31514-Ab-1/ GM-Tg-cang-T31514-Ab-2 | Anti-Canine GAA monoclonal antibody | Canine |
| GM-Tg-bovg-T31514-Ab-1/ GM-Tg-bovg-T31514-Ab-2 | Anti-Bovine GAA monoclonal antibody | Bovine |
| GM-Tg-equg-T31514-Ab-1/ GM-Tg-equg-T31514-Ab-2 | Anti-Equine GAA monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T31514-Ab-1/ GM-Tg-hg-T31514-Ab-2; GM-Tg-rg-T31514-Ab-1/ GM-Tg-rg-T31514-Ab-2; GM-Tg-mg-T31514-Ab-1/ GM-Tg-mg-T31514-Ab-2; GM-Tg-cynog-T31514-Ab-1/ GM-Tg-cynog-T31514-Ab-2; GM-Tg-felg-T31514-Ab-1/ GM-Tg-felg-T31514-Ab-2; GM-Tg-cang-T31514-Ab-1/ GM-Tg-cang-T31514-Ab-2; GM-Tg-bovg-T31514-Ab-1/ GM-Tg-bovg-T31514-Ab-2; GM-Tg-equg-T31514-Ab-1/ GM-Tg-equg-T31514-Ab-2 |
| Products Name | Anti-GAA monoclonal antibody |
| Format | mab |
| Target Name | GAA |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-GAA benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species LYAG/ GAA VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | vGMLP001507 | human GAA Lentivirus particle |
| ORF Viral Vector | pGMLP001507 | human GAA Lentivirus plasmid |
Target information
| Target ID | GM-T31514 |
| Target Name | GAA |
| Gene ID | 2548,14387,367562,712054,483352,101086359,280798,100056675 |
| Gene Symbol and Synonyms | E430018M07Rik,GAA,LYAG |
| Uniprot Accession | P10253,Q6P7A9,Q9MYM4 |
| Uniprot Entry Name | LYAG_HUMAN,LYAG_RAT,LYAG_BOVIN |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000171298 |
| Target Classification | N/A |
The target: GAA, gene name: GAA, also named as LYAG. This gene encodes lysosomal alpha-glucosidase, which is essential for the degradation of glycogen to glucose in lysosomes. The encoded preproprotein is proteolytically processed to generate multiple intermediate forms and the mature form of the enzyme. Defects in this gene are the cause of glycogen storage disease II, also known as Pompe's disease, which is an autosomal recessive disorder with a broad clinical spectrum. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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