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Anti-SPHK2 monoclonal antibody
Pre-made anti-SPHK2 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to SPHK2/SPHK2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T31989-Ab-1/ GM-Tg-hg-T31989-Ab-2 | Anti-Human SPHK2 monoclonal antibody | Human |
| GM-Tg-rg-T31989-Ab-1/ GM-Tg-rg-T31989-Ab-2 | Anti-Rat SPHK2 monoclonal antibody | Rat |
| GM-Tg-mg-T31989-Ab-1/ GM-Tg-mg-T31989-Ab-2 | Anti-Mouse SPHK2 monoclonal antibody | Mouse |
| GM-Tg-cynog-T31989-Ab-1/ GM-Tg-cynog-T31989-Ab-2 | Anti-Cynomolgus/ Rhesus macaque SPHK2 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T31989-Ab-1/ GM-Tg-felg-T31989-Ab-2 | Anti-Feline SPHK2 monoclonal antibody | Feline |
| GM-Tg-cang-T31989-Ab-1/ GM-Tg-cang-T31989-Ab-2 | Anti-Canine SPHK2 monoclonal antibody | Canine |
| GM-Tg-bovg-T31989-Ab-1/ GM-Tg-bovg-T31989-Ab-2 | Anti-Bovine SPHK2 monoclonal antibody | Bovine |
| GM-Tg-equg-T31989-Ab-1/ GM-Tg-equg-T31989-Ab-2 | Anti-Equine SPHK2 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T31989-Ab-1/ GM-Tg-hg-T31989-Ab-2; GM-Tg-rg-T31989-Ab-1/ GM-Tg-rg-T31989-Ab-2; GM-Tg-mg-T31989-Ab-1/ GM-Tg-mg-T31989-Ab-2; GM-Tg-cynog-T31989-Ab-1/ GM-Tg-cynog-T31989-Ab-2; GM-Tg-felg-T31989-Ab-1/ GM-Tg-felg-T31989-Ab-2; GM-Tg-cang-T31989-Ab-1/ GM-Tg-cang-T31989-Ab-2; GM-Tg-bovg-T31989-Ab-1/ GM-Tg-bovg-T31989-Ab-2; GM-Tg-equg-T31989-Ab-1/ GM-Tg-equg-T31989-Ab-2 |
| Products Name | Anti-SPHK2 monoclonal antibody |
| Format | mab |
| Target Name | SPHK2 |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-SPHK2 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T31989-Ag-1 | Recombinant multi-species SPHK2/ SK 2/ SK-2 protein |
| ORF Viral Vector | pGMAAV000300 | human SPHK2 AAV plasmid |
| ORF Viral Vector | vGMAAV000300 | human SPHK2 AAV particle |
| ORF Viral Vector | pGMLPm004048 | mouse Sphk2 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm004048 | mouse Sphk2 Lentivirus particle |
Target information
| Target ID | GM-T31989 |
| Target Name | SPHK2 |
| Gene ID | 56848,56632,308589,718088,484401,101081345,533103,100054066 |
| Gene Symbol and Synonyms | SK 2,SK-2,Sk2,SPHK2,SPK 2,SPK-2,Spk2 |
| Uniprot Accession | Q9NRA0 |
| Uniprot Entry Name | SPHK2_HUMAN |
| Protein Sub-location | Introcelluar Protein |
| Category | Therapeutics Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000063176 |
| Target Classification | N/A |
The target: SPHK2, gene name: SPHK2, also named as SK 2, SK-2, SPK 2, SPK-2. This gene encodes one of two sphingosine kinase isozymes that catalyze the phosphorylation of sphingosine into sphingosine 1-phosphate. Sphingosine 1-phosphate mediates many cellular processes including migration, proliferation and apoptosis, and also plays a role in several types of cancer by promoting angiogenesis and tumorigenesis. The encoded protein may play a role in breast cancer proliferation and chemoresistance. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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