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Anti-5HT2A/ HTR2A/ 5-HT2A monoclonal antibody
Anti-5HT2A/ HTR2A/ 5-HT2A antibody for FACS & in-vivo assay
Go to HTR2A/HTR2A products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T32060-Ab-1/ GM-Tg-hg-T32060-Ab-2 | Anti-Human HTR2A monoclonal antibody | Human |
| GM-Tg-rg-T32060-Ab-1/ GM-Tg-rg-T32060-Ab-2 | Anti-Rat HTR2A monoclonal antibody | Rat |
| GM-Tg-mg-T32060-Ab-1/ GM-Tg-mg-T32060-Ab-2 | Anti-Mouse HTR2A monoclonal antibody | Mouse |
| GM-Tg-cynog-T32060-Ab-1/ GM-Tg-cynog-T32060-Ab-2 | Anti-Cynomolgus/ Rhesus macaque HTR2A monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T32060-Ab-1/ GM-Tg-felg-T32060-Ab-2 | Anti-Feline HTR2A monoclonal antibody | Feline |
| GM-Tg-cang-T32060-Ab-1/ GM-Tg-cang-T32060-Ab-2 | Anti-Canine HTR2A monoclonal antibody | Canine |
| GM-Tg-bovg-T32060-Ab-1/ GM-Tg-bovg-T32060-Ab-2 | Anti-Bovine HTR2A monoclonal antibody | Bovine |
| GM-Tg-equg-T32060-Ab-1/ GM-Tg-equg-T32060-Ab-2 | Anti-Equine HTR2A monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T32060-Ab-1/ GM-Tg-hg-T32060-Ab-2; GM-Tg-rg-T32060-Ab-1/ GM-Tg-rg-T32060-Ab-2; GM-Tg-mg-T32060-Ab-1/ GM-Tg-mg-T32060-Ab-2; GM-Tg-cynog-T32060-Ab-1/ GM-Tg-cynog-T32060-Ab-2; GM-Tg-felg-T32060-Ab-1/ GM-Tg-felg-T32060-Ab-2; GM-Tg-cang-T32060-Ab-1/ GM-Tg-cang-T32060-Ab-2; GM-Tg-bovg-T32060-Ab-1/ GM-Tg-bovg-T32060-Ab-2; GM-Tg-equg-T32060-Ab-1/ GM-Tg-equg-T32060-Ab-2 |
| Products Name | Anti-HTR2A monoclonal antibody |
| Format | mab |
| Target Name | HTR2A |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-HTR2A benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species 5HT2A/ HTR2A/ 5-HT2A VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | vGMAP000503 | human HTR2A Adenovirus particle |
| ORF Viral Vector | pGMAP000503 | human HTR2A Adenovirus plasmid |
| ORF Viral Vector | pGMLP002120 | human HTR2A Lentivirus plasmid |
| ORF Viral Vector | vGMLP002120 | human HTR2A Lentivirus particle |
| ORF Viral Vector | pGMLPm002960 | mouse Htr2a Lentivirus plasmid |
| ORF Viral Vector | vGMLPm002960 | mouse Htr2a Lentivirus particle |
Target information
| Target ID | GM-T32060 |
| Target Name | HTR2A |
| Gene ID | 3356,15558,29595,613032,403882,101081108,407230,100009685 |
| Gene Symbol and Synonyms | 5-HT-2,5-HT-2A,5-HT2A,5-HTR2A,5Ht-2,5HT2A,5HTR2A,E030013E04,Htr-2,HTR2,HTR2A |
| Uniprot Accession | P28223,P14842,P50128,O46635,Q75Z89 |
| Uniprot Entry Name | 5HT2A_HUMAN,5HT2A_MACMU,5HT2A_RAT,5HT2A_CANLF,5HT2A_BOVIN |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target |
| Disease | Schizophrenia |
| Gene Ensembl | ENSG00000102468 |
| Target Classification | GPCR |
The target: HTR2A, gene name: HTR2A, also named as 5-HT2A, HTR2. This gene encodes one of the receptors for serotonin, a neurotransmitter with many roles. Mutations in this gene are associated with susceptibility to schizophrenia and obsessive-compulsive disorder, and are also associated with response to the antidepressant citalopram in patients with major depressive disorder (MDD). MDD patients who also have a mutation in intron 2 of this gene show a significantly reduced response to citalopram as this antidepressant downregulates expression of this gene. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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