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Anti-MBL2/ COLEC1/ HSMBPC functional antibody
Anti-MBL2/ COLEC1/ HSMBPC functional antibody for cell culture, ELISA & in-vivo assay
Go to MBL2/MBL2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T32699-Ab-1/ GM-Tg-hg-T32699-Ab-2 | Anti-Human MBL2 monoclonal antibody | Human |
| GM-Tg-rg-T32699-Ab-1/ GM-Tg-rg-T32699-Ab-2 | Anti-Rat MBL2 monoclonal antibody | Rat |
| GM-Tg-mg-T32699-Ab-1/ GM-Tg-mg-T32699-Ab-2 | Anti-Mouse MBL2 monoclonal antibody | Mouse |
| GM-Tg-cynog-T32699-Ab-1/ GM-Tg-cynog-T32699-Ab-2 | Anti-Cynomolgus/ Rhesus macaque MBL2 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T32699-Ab-1/ GM-Tg-felg-T32699-Ab-2 | Anti-Feline MBL2 monoclonal antibody | Feline |
| GM-Tg-cang-T32699-Ab-1/ GM-Tg-cang-T32699-Ab-2 | Anti-Canine MBL2 monoclonal antibody | Canine |
| GM-Tg-bovg-T32699-Ab-1/ GM-Tg-bovg-T32699-Ab-2 | Anti-Bovine MBL2 monoclonal antibody | Bovine |
| GM-Tg-equg-T32699-Ab-1/ GM-Tg-equg-T32699-Ab-2 | Anti-Equine MBL2 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T32699-Ab-1/ GM-Tg-hg-T32699-Ab-2; GM-Tg-rg-T32699-Ab-1/ GM-Tg-rg-T32699-Ab-2; GM-Tg-mg-T32699-Ab-1/ GM-Tg-mg-T32699-Ab-2; GM-Tg-cynog-T32699-Ab-1/ GM-Tg-cynog-T32699-Ab-2; GM-Tg-felg-T32699-Ab-1/ GM-Tg-felg-T32699-Ab-2; GM-Tg-cang-T32699-Ab-1/ GM-Tg-cang-T32699-Ab-2; GM-Tg-bovg-T32699-Ab-1/ GM-Tg-bovg-T32699-Ab-2; GM-Tg-equg-T32699-Ab-1/ GM-Tg-equg-T32699-Ab-2 |
| Products Name | Anti-MBL2 monoclonal antibody |
| Format | mab |
| Target Name | MBL2 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-MBL2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T32699-Ag-1 | Recombinant multi-species MBL2/ COLEC1/ HSMBPC protein |
| ORF Viral Vector | vGMLP000559 | human MBL2 Lentivirus particle |
| ORF Viral Vector | vGMAP000529 | Human MBL2 Adenovirus particle |
| ORF Viral Vector | pGMLP000559 | human MBL2 Lentivirus plasmid |
| ORF Viral Vector | pGMAP000529 | Human MBL2 Adenovirus plasmid |
| ORF Viral Vector | pGMLPm000412 | mouse Mbl2 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm000412 | mouse Mbl2 Lentivirus particle |
Target information
| Target ID | GM-T32699 |
| Target Name | MBL2 |
| Gene ID | 4153,17195,64668,702652,101100840,281297,100034103 |
| Gene Symbol and Synonyms | Ab2-001,Ab2-011,COLEC1,HSMBPC,L-MBP,MBL,MBL-C,MBL1,MBL2,MBL2D,MBP,MBP-C,MBP1,MBPD,RARF/P28A |
| Uniprot Accession | P11226,P08661,O02659 |
| Uniprot Entry Name | MBL2_HUMAN,MBL2_RAT,MBL2_BOVIN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | Therapeutics Target |
| Disease | Cancer |
| Gene Ensembl | ENSG00000165471 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: MBL2, gene name: MBL2, also named as COLEC1, HSMBPC, MBLD, MBP, MBP-C, MBP1, MBPD, MBL2. This gene encodes the soluble mannose-binding lectin or mannose-binding protein found in serum. The protein encoded belongs to the collectin family and is an important element in the innate immune system. The protein recognizes and binds to mannose and N-acetylglucosamine on many microorganisms, including bacteria, yeast, and viruses including influenza virus, HIV and SARS-CoV. This binding activates the classical complement pathway. Deficiencies of this gene have been associated with susceptibility to autoimmune and infectious diseases. [provided by RefSeq, Jun 2020].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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