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Anti-TNF15/ TNFSF15/ TL1 monoclonal antibody
Anti-TNF15/ TNFSF15/ TL1 antibody for FACS & in-vivo assay
Go to TNFSF15/TNFSF15 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T35212-Ab-1/ GM-Tg-hg-T35212-Ab-2 | Anti-Human TNFSF15 monoclonal antibody | Human |
| GM-Tg-rg-T35212-Ab-1/ GM-Tg-rg-T35212-Ab-2 | Anti-Rat TNFSF15 monoclonal antibody | Rat |
| GM-Tg-mg-T35212-Ab-1/ GM-Tg-mg-T35212-Ab-2 | Anti-Mouse TNFSF15 monoclonal antibody | Mouse |
| GM-Tg-cynog-T35212-Ab-1/ GM-Tg-cynog-T35212-Ab-2 | Anti-Cynomolgus/ Rhesus macaque TNFSF15 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T35212-Ab-1/ GM-Tg-felg-T35212-Ab-2 | Anti-Feline TNFSF15 monoclonal antibody | Feline |
| GM-Tg-cang-T35212-Ab-1/ GM-Tg-cang-T35212-Ab-2 | Anti-Canine TNFSF15 monoclonal antibody | Canine |
| GM-Tg-bovg-T35212-Ab-1/ GM-Tg-bovg-T35212-Ab-2 | Anti-Bovine TNFSF15 monoclonal antibody | Bovine |
| GM-Tg-equg-T35212-Ab-1/ GM-Tg-equg-T35212-Ab-2 | Anti-Equine TNFSF15 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T35212-Ab-1/ GM-Tg-hg-T35212-Ab-2; GM-Tg-rg-T35212-Ab-1/ GM-Tg-rg-T35212-Ab-2; GM-Tg-mg-T35212-Ab-1/ GM-Tg-mg-T35212-Ab-2; GM-Tg-cynog-T35212-Ab-1/ GM-Tg-cynog-T35212-Ab-2; GM-Tg-felg-T35212-Ab-1/ GM-Tg-felg-T35212-Ab-2; GM-Tg-cang-T35212-Ab-1/ GM-Tg-cang-T35212-Ab-2; GM-Tg-bovg-T35212-Ab-1/ GM-Tg-bovg-T35212-Ab-2; GM-Tg-equg-T35212-Ab-1/ GM-Tg-equg-T35212-Ab-2 |
| Products Name | Anti-TNFSF15 monoclonal antibody |
| Format | mab |
| Target Name | TNFSF15 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-TNFSF15 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species TNF15/ TNFSF15/ TL1 VLP (virus-like particle) (Products Developing) |
| Cytokine | GM-Tg-g-T35212-Ag-1 | Tumor necrosis factor superfamily member 15 (TNFSF15) protein |
| ORF Viral Vector | pGMLP004530 | human TNFSF15 Lentivirus plasmid |
| ORF Viral Vector | vGMLP004530 | human TNFSF15 Lentivirus particle |
| ORF Viral Vector | pGMAAV000281 | human TNFSF15 AAV plasmid |
| ORF Viral Vector | vGMAAV000281 | human TNFSF15 AAV particle |
| ORF Viral Vector | pGMLPm000509 | mouse Tnfsf15 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm000509 | mouse Tnfsf15 Lentivirus particle |
Target information
| Target ID | GM-T35212 |
| Target Name | TNFSF15 |
| Gene ID | 9966,326623,252878,703189,481688,101099505,514239,100049906 |
| Gene Symbol and Synonyms | TL1,TL1A,TNFSF15,TNLG1B,VEGI,VEGI192A |
| Uniprot Accession | O95150,Q8K3Y7 |
| Uniprot Entry Name | TNF15_HUMAN,TNF15_RAT |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target, Cytokine Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000181634 |
| Target Classification | N/A |
The target: TNFSF15, gene name: TNFSF15, also named as TL1, TL1A, TNLG1B, VEGI, VEGI192A. The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this protein is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It can activate NF-kappaB and MAP kinases, and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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