Anti-NECT4/ NECTIN4/ EDSS1 monoclonal antibody
Anti-NECT4/ NECTIN4/ EDSS1 antibody for FACS & in-vivo assay
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(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
Product information
Catalog No. | Product Name | Species Reactivity |
---|---|---|
GM-Tg-hg-T35591-Ab-1/ GM-Tg-hg-T35591-Ab-2 | Anti-Human NECTIN4 monoclonal antibody | Human |
GM-Tg-rg-T35591-Ab-1/ GM-Tg-rg-T35591-Ab-2 | Anti-Rat NECTIN4 monoclonal antibody | Rat |
GM-Tg-mg-T35591-Ab-1/ GM-Tg-mg-T35591-Ab-2 | Anti-Mouse NECTIN4 monoclonal antibody | Mouse |
GM-Tg-cynog-T35591-Ab-1/ GM-Tg-cynog-T35591-Ab-2 | Anti-Cynomolgus/ Rhesus macaque NECTIN4 monoclonal antibody | Cynomolgus/ Rhesus macaque |
GM-Tg-felg-T35591-Ab-1/ GM-Tg-felg-T35591-Ab-2 | Anti-Feline NECTIN4 monoclonal antibody | Feline |
GM-Tg-cang-T35591-Ab-1/ GM-Tg-cang-T35591-Ab-2 | Anti-Canine NECTIN4 monoclonal antibody | Canine |
GM-Tg-bovg-T35591-Ab-1/ GM-Tg-bovg-T35591-Ab-2 | Anti-Bovine NECTIN4 monoclonal antibody | Bovine |
GM-Tg-equg-T35591-Ab-1/ GM-Tg-equg-T35591-Ab-2 | Anti-Equine NECTIN4 monoclonal antibody | Equine |
Size: 1mg | 10mg | 100mg
Product Description
Catalog No. | GM-Tg-hg-T35591-Ab-1/ GM-Tg-hg-T35591-Ab-2; GM-Tg-rg-T35591-Ab-1/ GM-Tg-rg-T35591-Ab-2; GM-Tg-mg-T35591-Ab-1/ GM-Tg-mg-T35591-Ab-2; GM-Tg-cynog-T35591-Ab-1/ GM-Tg-cynog-T35591-Ab-2; GM-Tg-felg-T35591-Ab-1/ GM-Tg-felg-T35591-Ab-2; GM-Tg-cang-T35591-Ab-1/ GM-Tg-cang-T35591-Ab-2; GM-Tg-bovg-T35591-Ab-1/ GM-Tg-bovg-T35591-Ab-2; GM-Tg-equg-T35591-Ab-1/ GM-Tg-equg-T35591-Ab-2 |
Products Name | Anti-NECTIN4 monoclonal antibody |
Format | mab |
Target Name | NECTIN4 |
Protein Sub-location | Transmembrane Protein |
Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
Derivation (species) | Mouse |
CH1+2+3 Isotype (Receptor identification) | IgG |
Type of Light Chain (VD-LC) | N/A |
Expression platform | Mammalian Expression |
Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
Tag | Fc |
Products description | Pre-made anti-NECTIN4 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
Purity | Purity: ≥95% (SDS-PAGE) |
Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
Formulation | Lyophilized from sterile PBS, PH 7.4 |
Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
Category | Cat No. | Products Name |
Biosimilar | GMP-Bios-INN-833 | Pre-Made Enfortumab Vedotin Biosimilar, Whole Mab Adc, Anti-PVRL4/NECTIN4 Antibody: Anti-EDSS1/LNIR/PRR4/nectin-4 therapeutic antibody Drug Conjugate |
Biosimilar | GMP-Bios-ab-182 | Pre-Made Enfortumab biosimilar, Whole mAb ADC, Anti-PVRL4/NECTIN4 Antibody: Anti-EDSS1/LNIR/PRR4/nectin-4 therapeutic antibody |
Target Antigen | Products Developing | Multi-species NECT4/ NECTIN4/ EDSS1 VLP (virus-like particle) (Products Developing) |
ORF Viral Vector | vGMLP002312 | human NECTIN4 Lentivirus particle |
ORF Viral Vector | pGMLP002312 | human NECTIN4 Lentivirus plasmid |
Target information
Target ID | GM-T35591 |
Target Name | NECTIN4 |
Gene ID | 81607,71740,498281,719843,609931,101092485,507718,100066309 |
Gene Symbol and Synonyms | 1200017F15Rik,EDSS1,LNIR,nectin-4,NECTIN4,PRR4,PVRL4,RGD1559826 |
Uniprot Accession | Q96NY8,Q5E9Z9 |
Uniprot Entry Name | NECT4_HUMAN,NECT4_BOVIN |
Protein Sub-location | Transmembrane Protein |
Category | Therapeutics Target, Immuno-oncology Target, INN Index |
Disease | Breast Cancer, Mucocutaneous lymph node syndrome [Kawasaki] |
Gene Ensembl | ENSG00000143217 |
Target Classification | Checkpoint-Immuno Oncology |
The target: NECTIN4, gene name: NECTIN4, also named as EDSS1, LNIR, PRR4, PVRL4, nectin-4. This gene encodes a member of the nectin family. The encoded protein contains two immunoglobulin-like (Ig-like) C2-type domains and one Ig-like V-type domain. It is involved in cell adhesion through trans-homophilic and -heterophilic interactions. It is a single-pass type I membrane protein. The soluble form is produced by proteolytic cleavage at the cell surface by the metalloproteinase ADAM17/TACE. The secreted form is found in both breast tumor cell lines and breast tumor patients. Mutations in this gene are the cause of ectodermal dysplasia-syndactyly syndrome type 1, an autosomal recessive disorder. Alternatively spliced transcript variants have been found but the full-length nature of the variant has not been determined.[provided by RefSeq, Jan 2011].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.