Anti-NECT4/ NECTIN4/ EDSS1 monoclonal antibody

Anti-NECT4/ NECTIN4/ EDSS1 antibody for FACS & in-vivo assay

Target products collectionGo to NECTIN4/NECTIN4 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)


Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T35591-Ab-1/ GM-Tg-hg-T35591-Ab-2Anti-Human NECTIN4 monoclonal antibodyHuman
GM-Tg-rg-T35591-Ab-1/ GM-Tg-rg-T35591-Ab-2Anti-Rat NECTIN4 monoclonal antibodyRat
GM-Tg-mg-T35591-Ab-1/ GM-Tg-mg-T35591-Ab-2Anti-Mouse NECTIN4 monoclonal antibodyMouse
GM-Tg-cynog-T35591-Ab-1/ GM-Tg-cynog-T35591-Ab-2Anti-Cynomolgus/ Rhesus macaque NECTIN4 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T35591-Ab-1/ GM-Tg-felg-T35591-Ab-2Anti-Feline NECTIN4 monoclonal antibodyFeline
GM-Tg-cang-T35591-Ab-1/ GM-Tg-cang-T35591-Ab-2Anti-Canine NECTIN4 monoclonal antibodyCanine
GM-Tg-bovg-T35591-Ab-1/ GM-Tg-bovg-T35591-Ab-2Anti-Bovine NECTIN4 monoclonal antibodyBovine
GM-Tg-equg-T35591-Ab-1/ GM-Tg-equg-T35591-Ab-2Anti-Equine NECTIN4 monoclonal antibodyEquine

Size: 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T35591-Ab-1/ GM-Tg-hg-T35591-Ab-2; GM-Tg-rg-T35591-Ab-1/ GM-Tg-rg-T35591-Ab-2;
GM-Tg-mg-T35591-Ab-1/ GM-Tg-mg-T35591-Ab-2; GM-Tg-cynog-T35591-Ab-1/ GM-Tg-cynog-T35591-Ab-2;
GM-Tg-felg-T35591-Ab-1/ GM-Tg-felg-T35591-Ab-2; GM-Tg-cang-T35591-Ab-1/ GM-Tg-cang-T35591-Ab-2;
GM-Tg-bovg-T35591-Ab-1/ GM-Tg-bovg-T35591-Ab-2; GM-Tg-equg-T35591-Ab-1/ GM-Tg-equg-T35591-Ab-2
Products NameAnti-NECTIN4 monoclonal antibody
Formatmab
Target NameNECTIN4
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)
IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-NECTIN4 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


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    Associated products


    CategoryCat No.Products Name
    BiosimilarGMP-Bios-INN-833Pre-Made Enfortumab Vedotin Biosimilar, Whole Mab Adc, Anti-PVRL4/NECTIN4 Antibody: Anti-EDSS1/LNIR/PRR4/nectin-4 therapeutic antibody Drug Conjugate
    BiosimilarGMP-Bios-ab-182Pre-Made Enfortumab biosimilar, Whole mAb ADC, Anti-PVRL4/NECTIN4 Antibody: Anti-EDSS1/LNIR/PRR4/nectin-4 therapeutic antibody
    Target AntigenProducts DevelopingMulti-species NECT4/ NECTIN4/ EDSS1 VLP (virus-like particle) (Products Developing)
    ORF Viral VectorvGMLP002312human NECTIN4 Lentivirus particle
    ORF Viral VectorpGMLP002312human NECTIN4 Lentivirus plasmid


    Target information

    Target IDGM-T35591
    Target NameNECTIN4
    Gene ID81607,71740,498281,719843,609931,101092485,507718,100066309
    Gene Symbol and Synonyms1200017F15Rik,EDSS1,LNIR,nectin-4,NECTIN4,PRR4,PVRL4,RGD1559826
    Uniprot AccessionQ96NY8,Q5E9Z9
    Uniprot Entry NameNECT4_HUMAN,NECT4_BOVIN
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target, Immuno-oncology Target, INN Index
    DiseaseBreast Cancer, Mucocutaneous lymph node syndrome [Kawasaki]
    Gene EnsemblENSG00000143217
    Target ClassificationCheckpoint-Immuno Oncology

    The target: NECTIN4, gene name: NECTIN4, also named as EDSS1, LNIR, PRR4, PVRL4, nectin-4. This gene encodes a member of the nectin family. The encoded protein contains two immunoglobulin-like (Ig-like) C2-type domains and one Ig-like V-type domain. It is involved in cell adhesion through trans-homophilic and -heterophilic interactions. It is a single-pass type I membrane protein. The soluble form is produced by proteolytic cleavage at the cell surface by the metalloproteinase ADAM17/TACE. The secreted form is found in both breast tumor cell lines and breast tumor patients. Mutations in this gene are the cause of ectodermal dysplasia-syndactyly syndrome type 1, an autosomal recessive disorder. Alternatively spliced transcript variants have been found but the full-length nature of the variant has not been determined.[provided by RefSeq, Jan 2011].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.