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Anti-MP2K1/ MEK1/ MAP2K1 monoclonal antibody
Anti-MP2K1/ MEK1/ MAP2K1 antibody for FACS & in-vivo assay
Go to MEK1/MAP2K1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T35940-Ab-1/ GM-Tg-hg-T35940-Ab-2 | Anti-Human MEK1/MAP2K1 monoclonal antibody | Human |
| GM-Tg-rg-T35940-Ab-1/ GM-Tg-rg-T35940-Ab-2 | Anti-Rat MEK1/MAP2K1 monoclonal antibody | Rat |
| GM-Tg-mg-T35940-Ab-1/ GM-Tg-mg-T35940-Ab-2 | Anti-Mouse MEK1/MAP2K1 monoclonal antibody | Mouse |
| GM-Tg-cynog-T35940-Ab-1/ GM-Tg-cynog-T35940-Ab-2 | Anti-Cynomolgus/ Rhesus macaque MEK1/MAP2K1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T35940-Ab-1/ GM-Tg-felg-T35940-Ab-2 | Anti-Feline MEK1/MAP2K1 monoclonal antibody | Feline |
| GM-Tg-cang-T35940-Ab-1/ GM-Tg-cang-T35940-Ab-2 | Anti-Canine MEK1/MAP2K1 monoclonal antibody | Canine |
| GM-Tg-bovg-T35940-Ab-1/ GM-Tg-bovg-T35940-Ab-2 | Anti-Bovine MEK1/MAP2K1 monoclonal antibody | Bovine |
| GM-Tg-equg-T35940-Ab-1/ GM-Tg-equg-T35940-Ab-2 | Anti-Equine MEK1/MAP2K1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T35940-Ab-1/ GM-Tg-hg-T35940-Ab-2; GM-Tg-rg-T35940-Ab-1/ GM-Tg-rg-T35940-Ab-2; GM-Tg-mg-T35940-Ab-1/ GM-Tg-mg-T35940-Ab-2; GM-Tg-cynog-T35940-Ab-1/ GM-Tg-cynog-T35940-Ab-2; GM-Tg-felg-T35940-Ab-1/ GM-Tg-felg-T35940-Ab-2; GM-Tg-cang-T35940-Ab-1/ GM-Tg-cang-T35940-Ab-2; GM-Tg-bovg-T35940-Ab-1/ GM-Tg-bovg-T35940-Ab-2; GM-Tg-equg-T35940-Ab-1/ GM-Tg-equg-T35940-Ab-2 |
| Products Name | Anti-MEK1/MAP2K1 monoclonal antibody |
| Format | mab |
| Target Name | MEK1 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-MEK1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species MP2K1/ MEK1/ MAP2K1 VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | vGMLP003117 | human MAP2K1 Lentivirus particle |
| ORF Viral Vector | pGMLP003117 | human MAP2K1 Lentivirus plasmid |
| ORF Viral Vector | pGMLPm002321 | mouse Map2k1 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm002321 | mouse Map2k1 Lentivirus particle |
Target information
| Target ID | GM-T35940 |
| Target Name | MEK1 |
| Gene ID | 5604,26395,170851,710415,478347,101081387,533199,100065996 |
| Gene Symbol and Synonyms | CFC3,MAP2K1,MAPKK1,MEK1,MEKK1,MEL,MKK1,PRKMK1 |
| Uniprot Accession | Q02750,Q01986 |
| Uniprot Entry Name | MP2K1_HUMAN,MP2K1_RAT |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target |
| Disease | Non-Small Cell Lung Cancer, Breast Cancer |
| Gene Ensembl | ENSG00000169032 |
| Target Classification | Kinase |
The target: MEK1, gene name: MAP2K1, also named as CFC3, MAPKK1, MEK1, MKK1, PRKMK1. The protein encoded by this gene is a member of the dual specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein kinase lies upstream of MAP kinases and stimulates the enzymatic activity of MAP kinases upon wide variety of extra- and intracellular signals. As an essential component of MAP kinase signal transduction pathway, this kinase is involved in many cellular processes such as proliferation, differentiation, transcription regulation and development. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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