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Anti-ACVL1/ ACVRL1/ ACVRLK1 monoclonal antibody
Anti-ACVL1/ ACVRL1/ ACVRLK1 antibody for FACS & in-vivo assay
Go to ACVRL1/ACVRL1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T36959-Ab-1/ GM-Tg-hg-T36959-Ab-2 | Anti-Human ACVRL1 monoclonal antibody | Human |
| GM-Tg-rg-T36959-Ab-1/ GM-Tg-rg-T36959-Ab-2 | Anti-Rat ACVRL1 monoclonal antibody | Rat |
| GM-Tg-mg-T36959-Ab-1/ GM-Tg-mg-T36959-Ab-2 | Anti-Mouse ACVRL1 monoclonal antibody | Mouse |
| GM-Tg-cynog-T36959-Ab-1/ GM-Tg-cynog-T36959-Ab-2 | Anti-Cynomolgus/ Rhesus macaque ACVRL1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T36959-Ab-1/ GM-Tg-felg-T36959-Ab-2 | Anti-Feline ACVRL1 monoclonal antibody | Feline |
| GM-Tg-cang-T36959-Ab-1/ GM-Tg-cang-T36959-Ab-2 | Anti-Canine ACVRL1 monoclonal antibody | Canine |
| GM-Tg-bovg-T36959-Ab-1/ GM-Tg-bovg-T36959-Ab-2 | Anti-Bovine ACVRL1 monoclonal antibody | Bovine |
| GM-Tg-equg-T36959-Ab-1/ GM-Tg-equg-T36959-Ab-2 | Anti-Equine ACVRL1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T36959-Ab-1/ GM-Tg-hg-T36959-Ab-2; GM-Tg-rg-T36959-Ab-1/ GM-Tg-rg-T36959-Ab-2; GM-Tg-mg-T36959-Ab-1/ GM-Tg-mg-T36959-Ab-2; GM-Tg-cynog-T36959-Ab-1/ GM-Tg-cynog-T36959-Ab-2; GM-Tg-felg-T36959-Ab-1/ GM-Tg-felg-T36959-Ab-2; GM-Tg-cang-T36959-Ab-1/ GM-Tg-cang-T36959-Ab-2; GM-Tg-bovg-T36959-Ab-1/ GM-Tg-bovg-T36959-Ab-2; GM-Tg-equg-T36959-Ab-1/ GM-Tg-equg-T36959-Ab-2 |
| Products Name | Anti-ACVRL1 monoclonal antibody |
| Format | mab |
| Target Name | ACVRL1 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-ACVRL1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Biosimilar | GMP-Bios-ab-032 | Pre-Made Ascrinvacumab biosimilar, Whole mAb, Anti-ACVRL1 Antibody: Anti-ACVRLK1/ALK-1/ALK1/HHT/HHT2/ORW2/SKR3/TSR-I therapeutic antibody |
| Target Antigen | Products Developing | Multi-species ACVL1/ ACVRL1/ ACVRLK1 VLP (virus-like particle) (Products Developing) |
| Cytokine | GM-Tg-g-T36959-Ag-1 | activin A receptor type II-like 1 (ACVRL1) protein |
| ORF Viral Vector | pGMLPm004968 | mouse Acvrl1 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm004968 | mouse Acvrl1 Lentivirus particle |
Target information
| Target ID | GM-T36959 |
| Target Name | ACVRL1 |
| Gene ID | 94,11482,25237,696471,477603,101097406,534536,100061313 |
| Gene Symbol and Synonyms | ACVRL1,ACVRLK1,ALK-1,ALK1,HHT,HHT2,ORW2,R-3,R3,SETHKIR,SKR3,TSR-I |
| Uniprot Accession | P37023,P80203 |
| Uniprot Entry Name | ACVL1_HUMAN,ACVL1_RAT |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target, INN Index, Cytokine Target |
| Disease | Cancer |
| Gene Ensembl | ENSG00000139567 |
| Target Classification | Kinase, Tumor-associated antigen (TAA) |
The target: ACVRL1, gene name: ACVRL1, also named as ACVRLK1, ALK-1, ALK1, HHT, HHT2, ORW2, SKR3, TSR-I. This gene encodes a type I cell-surface receptor for the TGF-beta superfamily of ligands. It shares with other type I receptors a high degree of similarity in serine-threonine kinase subdomains, a glycine- and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail. The encoded protein, sometimes termed ALK1, shares similar domain structures with other closely related ALK or activin receptor-like kinase proteins that form a subfamily of receptor serine/threonine kinases. Mutations in this gene are associated with hemorrhagic telangiectasia type 2, also known as Rendu-Osler-Weber syndrome 2. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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