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Anti-FA5/ F5/ FVL monoclonal antibody
Anti-FA5/ F5/ FVL antibody for FACS & in-vivo assay
Go to F5/F5 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T37510-Ab-1/ GM-Tg-hg-T37510-Ab-2 | Anti-Human F5 monoclonal antibody | Human |
| GM-Tg-rg-T37510-Ab-1/ GM-Tg-rg-T37510-Ab-2 | Anti-Rat F5 monoclonal antibody | Rat |
| GM-Tg-mg-T37510-Ab-1/ GM-Tg-mg-T37510-Ab-2 | Anti-Mouse F5 monoclonal antibody | Mouse |
| GM-Tg-cynog-T37510-Ab-1/ GM-Tg-cynog-T37510-Ab-2 | Anti-Cynomolgus/ Rhesus macaque F5 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T37510-Ab-1/ GM-Tg-felg-T37510-Ab-2 | Anti-Feline F5 monoclonal antibody | Feline |
| GM-Tg-cang-T37510-Ab-1/ GM-Tg-cang-T37510-Ab-2 | Anti-Canine F5 monoclonal antibody | Canine |
| GM-Tg-bovg-T37510-Ab-1/ GM-Tg-bovg-T37510-Ab-2 | Anti-Bovine F5 monoclonal antibody | Bovine |
| GM-Tg-equg-T37510-Ab-1/ GM-Tg-equg-T37510-Ab-2 | Anti-Equine F5 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T37510-Ab-1/ GM-Tg-hg-T37510-Ab-2; GM-Tg-rg-T37510-Ab-1/ GM-Tg-rg-T37510-Ab-2; GM-Tg-mg-T37510-Ab-1/ GM-Tg-mg-T37510-Ab-2; GM-Tg-cynog-T37510-Ab-1/ GM-Tg-cynog-T37510-Ab-2; GM-Tg-felg-T37510-Ab-1/ GM-Tg-felg-T37510-Ab-2; GM-Tg-cang-T37510-Ab-1/ GM-Tg-cang-T37510-Ab-2; GM-Tg-bovg-T37510-Ab-1/ GM-Tg-bovg-T37510-Ab-2; GM-Tg-equg-T37510-Ab-1/ GM-Tg-equg-T37510-Ab-2 |
| Products Name | Anti-F5 monoclonal antibody |
| Format | mab |
| Target Name | F5 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-F5 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species FA5/ F5/ FVL VLP (virus-like particle) (Products Developing) |
Target information
| Target ID | GM-T37510 |
| Target Name | F5 |
| Gene ID | 2153,14067,304929,704695,100685858,101085264,280687,100058503 |
| Gene Symbol and Synonyms | Ac2-120,Cf-5,Cf5,F5,FVL,PCCF,RPRGL1,THPH2 |
| Uniprot Accession | P12259,Q28107 |
| Uniprot Entry Name | FA5_HUMAN,FA5_BOVIN |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000198734 |
| Target Classification | N/A |
The target: F5, gene name: F5, also named as FVL, PCCF, RPRGL1, THPH2. This gene encodes an essential cofactor of the blood coagulation cascade. This factor circulates in plasma, and is converted to the active form by the release of the activation peptide by thrombin during coagulation. This generates a heavy chain and a light chain which are held together by calcium ions. The activated protein is a cofactor that participates with activated coagulation factor X to activate prothrombin to thrombin. Defects in this gene result in either an autosomal recessive hemorrhagic diathesis or an autosomal dominant form of thrombophilia, which is known as activated protein C resistance. [provided by RefSeq, Oct 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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