Anti-LAIR1/ CD305/ LAIR-1 monoclonal antibody
Anti-LAIR1/ CD305/ LAIR-1 antibody for FACS & in-vivo assay
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(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
Product information
Catalog No. | Product Name | Species Reactivity |
---|---|---|
GM-Tg-hg-T39047-Ab-1/ GM-Tg-hg-T39047-Ab-2 | Anti-Human LAIR1 monoclonal antibody | Human |
GM-Tg-rg-T39047-Ab-1/ GM-Tg-rg-T39047-Ab-2 | Anti-Rat LAIR1 monoclonal antibody | Rat |
GM-Tg-mg-T39047-Ab-1/ GM-Tg-mg-T39047-Ab-2 | Anti-Mouse LAIR1 monoclonal antibody | Mouse |
GM-Tg-cynog-T39047-Ab-1/ GM-Tg-cynog-T39047-Ab-2 | Anti-Cynomolgus/ Rhesus macaque LAIR1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
GM-Tg-felg-T39047-Ab-1/ GM-Tg-felg-T39047-Ab-2 | Anti-Feline LAIR1 monoclonal antibody | Feline |
GM-Tg-cang-T39047-Ab-1/ GM-Tg-cang-T39047-Ab-2 | Anti-Canine LAIR1 monoclonal antibody | Canine |
GM-Tg-bovg-T39047-Ab-1/ GM-Tg-bovg-T39047-Ab-2 | Anti-Bovine LAIR1 monoclonal antibody | Bovine |
GM-Tg-equg-T39047-Ab-1/ GM-Tg-equg-T39047-Ab-2 | Anti-Equine LAIR1 monoclonal antibody | Equine |
Size: 1mg | 10mg | 100mg
Product Description
Catalog No. | GM-Tg-hg-T39047-Ab-1/ GM-Tg-hg-T39047-Ab-2; GM-Tg-rg-T39047-Ab-1/ GM-Tg-rg-T39047-Ab-2; GM-Tg-mg-T39047-Ab-1/ GM-Tg-mg-T39047-Ab-2; GM-Tg-cynog-T39047-Ab-1/ GM-Tg-cynog-T39047-Ab-2; GM-Tg-felg-T39047-Ab-1/ GM-Tg-felg-T39047-Ab-2; GM-Tg-cang-T39047-Ab-1/ GM-Tg-cang-T39047-Ab-2; GM-Tg-bovg-T39047-Ab-1/ GM-Tg-bovg-T39047-Ab-2; GM-Tg-equg-T39047-Ab-1/ GM-Tg-equg-T39047-Ab-2 |
Products Name | Anti-LAIR1 monoclonal antibody |
Format | mab |
Target Name | LAIR1 |
Protein Sub-location | Transmembrane Protein |
Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
Derivation (species) | Mouse |
CH1+2+3 Isotype (Receptor identification) | IgG |
Type of Light Chain (VD-LC) | N/A |
Expression platform | Mammalian Expression |
Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
Tag | Fc |
Products description | Pre-made anti-LAIR1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
Purity | Purity: ≥95% (SDS-PAGE) |
Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
Formulation | Lyophilized from sterile PBS, PH 7.4 |
Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
Category | Cat No. | Products Name |
Target Antigen | Products Developing | Multi-species LAIR1/ CD305/ LAIR-1 VLP (virus-like particle) (Products Developing) |
ORF Viral Vector | pGMLP003875 | human LAIR1 Lentivirus plasmid |
ORF Viral Vector | vGMLP003875 | human LAIR1 Lentivirus particle |
ORF Viral Vector | pGMLP003510 | human LAIR1 Lentivirus plasmid |
ORF Viral Vector | vGMLP003510 | human LAIR1 Lentivirus particle |
ORF Viral Vector | pGMLPm000403 | mouse Lair1 Lentivirus plasmid |
ORF Viral Vector | vGMLPm000403 | mouse Lair1 Lentivirus particle |
Target information
Target ID | GM-T39047 |
Target Name | LAIR1 |
Gene ID | 3903,574531,484308,101081847,615295,102149211 |
Gene Symbol and Synonyms | CD305,LAIR-1,LAIR1 |
Uniprot Accession | Q6GTX8,P0C1X9 |
Uniprot Entry Name | LAIR1_HUMAN,LAIR1_RAT |
Protein Sub-location | Transmembrane Protein |
Category | Therapeutics Target |
Disease | Pregnant state |
Gene Ensembl | ENSG00000167613 |
Target Classification | N/A |
The target: LAIR1, gene name: LAIR1, also named as CD305, LAIR-1. The protein encoded by this gene is an inhibitory receptor found on peripheral mononuclear cells, including natural killer cells, T cells, and B cells. Inhibitory receptors regulate the immune response to prevent lysis of cells recognized as self. The gene is a member of both the immunoglobulin superfamily and the leukocyte-associated inhibitory receptor family. The gene maps to a region of 19q13.4 called the leukocyte receptor cluster, which contains at least 29 genes encoding leukocyte-expressed receptors of the immunoglobulin superfamily. The encoded protein has been identified as an anchor for tyrosine phosphatase SHP-1, and may induce cell death in myeloid leukemias. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.