Anti-LAIR1/ CD305/ LAIR-1 monoclonal antibody

Anti-LAIR1/ CD305/ LAIR-1 antibody for FACS & in-vivo assay

Target products collectionGo to LAIR1/LAIR1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)


Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T39047-Ab-1/ GM-Tg-hg-T39047-Ab-2Anti-Human LAIR1 monoclonal antibodyHuman
GM-Tg-rg-T39047-Ab-1/ GM-Tg-rg-T39047-Ab-2Anti-Rat LAIR1 monoclonal antibodyRat
GM-Tg-mg-T39047-Ab-1/ GM-Tg-mg-T39047-Ab-2Anti-Mouse LAIR1 monoclonal antibodyMouse
GM-Tg-cynog-T39047-Ab-1/ GM-Tg-cynog-T39047-Ab-2Anti-Cynomolgus/ Rhesus macaque LAIR1 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T39047-Ab-1/ GM-Tg-felg-T39047-Ab-2Anti-Feline LAIR1 monoclonal antibodyFeline
GM-Tg-cang-T39047-Ab-1/ GM-Tg-cang-T39047-Ab-2Anti-Canine LAIR1 monoclonal antibodyCanine
GM-Tg-bovg-T39047-Ab-1/ GM-Tg-bovg-T39047-Ab-2Anti-Bovine LAIR1 monoclonal antibodyBovine
GM-Tg-equg-T39047-Ab-1/ GM-Tg-equg-T39047-Ab-2Anti-Equine LAIR1 monoclonal antibodyEquine

Size: 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T39047-Ab-1/ GM-Tg-hg-T39047-Ab-2; GM-Tg-rg-T39047-Ab-1/ GM-Tg-rg-T39047-Ab-2;
GM-Tg-mg-T39047-Ab-1/ GM-Tg-mg-T39047-Ab-2; GM-Tg-cynog-T39047-Ab-1/ GM-Tg-cynog-T39047-Ab-2;
GM-Tg-felg-T39047-Ab-1/ GM-Tg-felg-T39047-Ab-2; GM-Tg-cang-T39047-Ab-1/ GM-Tg-cang-T39047-Ab-2;
GM-Tg-bovg-T39047-Ab-1/ GM-Tg-bovg-T39047-Ab-2; GM-Tg-equg-T39047-Ab-1/ GM-Tg-equg-T39047-Ab-2
Products NameAnti-LAIR1 monoclonal antibody
Formatmab
Target NameLAIR1
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)
IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-LAIR1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


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    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species LAIR1/ CD305/ LAIR-1 VLP (virus-like particle) (Products Developing)
    ORF Viral VectorpGMLP003875human LAIR1 Lentivirus plasmid
    ORF Viral VectorvGMLP003875human LAIR1 Lentivirus particle
    ORF Viral VectorpGMLP003510human LAIR1 Lentivirus plasmid
    ORF Viral VectorvGMLP003510human LAIR1 Lentivirus particle
    ORF Viral VectorpGMLPm000403mouse Lair1 Lentivirus plasmid
    ORF Viral VectorvGMLPm000403mouse Lair1 Lentivirus particle


    Target information

    Target IDGM-T39047
    Target NameLAIR1
    Gene ID3903,574531,484308,101081847,615295,102149211
    Gene Symbol and SynonymsCD305,LAIR-1,LAIR1
    Uniprot AccessionQ6GTX8,P0C1X9
    Uniprot Entry NameLAIR1_HUMAN,LAIR1_RAT
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target
    DiseasePregnant state
    Gene EnsemblENSG00000167613
    Target ClassificationN/A

    The target: LAIR1, gene name: LAIR1, also named as CD305, LAIR-1. The protein encoded by this gene is an inhibitory receptor found on peripheral mononuclear cells, including natural killer cells, T cells, and B cells. Inhibitory receptors regulate the immune response to prevent lysis of cells recognized as self. The gene is a member of both the immunoglobulin superfamily and the leukocyte-associated inhibitory receptor family. The gene maps to a region of 19q13.4 called the leukocyte receptor cluster, which contains at least 29 genes encoding leukocyte-expressed receptors of the immunoglobulin superfamily. The encoded protein has been identified as an anchor for tyrosine phosphatase SHP-1, and may induce cell death in myeloid leukemias. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.