- • Up to 20% off your first purchase
- • Bulk quantities available
- • Citation Reward application
Sample Application
- Animal health test
- In-vitro diagnostics
- Food & Feed Safety
- Environmental Safety
- New drug discovery
Supports
- Talk to our Expert:
[email protected] -
Talk to our sales:
[email protected]
Protocol Library Download
 |
 |
Anti-PLK1 monoclonal antibody
Pre-made anti-PLK1 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to PLK1/PLK1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T40694-Ab-1/ GM-Tg-hg-T40694-Ab-2 | Anti-Human PLK1 monoclonal antibody | Human |
| GM-Tg-rg-T40694-Ab-1/ GM-Tg-rg-T40694-Ab-2 | Anti-Rat PLK1 monoclonal antibody | Rat |
| GM-Tg-mg-T40694-Ab-1/ GM-Tg-mg-T40694-Ab-2 | Anti-Mouse PLK1 monoclonal antibody | Mouse |
| GM-Tg-cynog-T40694-Ab-1/ GM-Tg-cynog-T40694-Ab-2 | Anti-Cynomolgus/ Rhesus macaque PLK1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T40694-Ab-1/ GM-Tg-felg-T40694-Ab-2 | Anti-Feline PLK1 monoclonal antibody | Feline |
| GM-Tg-cang-T40694-Ab-1/ GM-Tg-cang-T40694-Ab-2 | Anti-Canine PLK1 monoclonal antibody | Canine |
| GM-Tg-bovg-T40694-Ab-1/ GM-Tg-bovg-T40694-Ab-2 | Anti-Bovine PLK1 monoclonal antibody | Bovine |
| GM-Tg-equg-T40694-Ab-1/ GM-Tg-equg-T40694-Ab-2 | Anti-Equine PLK1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T40694-Ab-1/ GM-Tg-hg-T40694-Ab-2; GM-Tg-rg-T40694-Ab-1/ GM-Tg-rg-T40694-Ab-2; GM-Tg-mg-T40694-Ab-1/ GM-Tg-mg-T40694-Ab-2; GM-Tg-cynog-T40694-Ab-1/ GM-Tg-cynog-T40694-Ab-2; GM-Tg-felg-T40694-Ab-1/ GM-Tg-felg-T40694-Ab-2; GM-Tg-cang-T40694-Ab-1/ GM-Tg-cang-T40694-Ab-2; GM-Tg-bovg-T40694-Ab-1/ GM-Tg-bovg-T40694-Ab-2; GM-Tg-equg-T40694-Ab-1/ GM-Tg-equg-T40694-Ab-2 |
| Products Name | Anti-PLK1 monoclonal antibody |
| Format | mab |
| Target Name | PLK1 |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-PLK1 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T40694-Ag-1 | Recombinant multi-species PLK1/ PLK/ STPK13 protein |
| ORF Viral Vector | vGMAP000536 | Human PLK1 Adenovirus particle |
| ORF Viral Vector | pGMAP000536 | Human PLK1 Adenovirus plasmid |
Target information
| Target ID | GM-T40694 |
| Target Name | PLK1 |
| Gene ID | 5347,18817,25515,697686,489971,101098508,538238,100068388 |
| Gene Symbol and Synonyms | PLK,PLK1,STPK13 |
| Uniprot Accession | P53350,Q62673,Q2TA25 |
| Uniprot Entry Name | PLK1_HUMAN,PLK1_RAT,PLK1_BOVIN |
| Protein Sub-location | Introcelluar Protein |
| Category | Therapeutics Target |
| Disease | Cancer |
| Gene Ensembl | ENSG00000166851 |
| Target Classification | Kinase, Tumor-associated antigen (TAA) |
The target: PLK1, gene name: PLK1, also named as PLK, STPK13. The Ser/Thr protein kinase encoded by this gene belongs to the CDC5/Polo subfamily. It is highly expressed during mitosis and elevated levels are found in many different types of cancer. Depletion of this protein in cancer cells dramatically inhibited cell proliferation and induced apoptosis; hence, it is a target for cancer therapy. [provided by RefSeq, Sep 2015].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
Facebook
LinkedIn
Twitter
