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Anti-TLR5/ MELIOS/ SLE1 monoclonal antibody
Anti-TLR5/ MELIOS/ SLE1 antibody for FACS & in-vivo assay
Go to TLR5/TLR5 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T43718-Ab-1/ GM-Tg-hg-T43718-Ab-2 | Anti-Human TLR5 monoclonal antibody | Human |
| GM-Tg-rg-T43718-Ab-1/ GM-Tg-rg-T43718-Ab-2 | Anti-Rat TLR5 monoclonal antibody | Rat |
| GM-Tg-mg-T43718-Ab-1/ GM-Tg-mg-T43718-Ab-2 | Anti-Mouse TLR5 monoclonal antibody | Mouse |
| GM-Tg-cynog-T43718-Ab-1/ GM-Tg-cynog-T43718-Ab-2 | Anti-Cynomolgus/ Rhesus macaque TLR5 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T43718-Ab-1/ GM-Tg-felg-T43718-Ab-2 | Anti-Feline TLR5 monoclonal antibody | Feline |
| GM-Tg-cang-T43718-Ab-1/ GM-Tg-cang-T43718-Ab-2 | Anti-Canine TLR5 monoclonal antibody | Canine |
| GM-Tg-bovg-T43718-Ab-1/ GM-Tg-bovg-T43718-Ab-2 | Anti-Bovine TLR5 monoclonal antibody | Bovine |
| GM-Tg-equg-T43718-Ab-1/ GM-Tg-equg-T43718-Ab-2 | Anti-Equine TLR5 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T43718-Ab-1/ GM-Tg-hg-T43718-Ab-2; GM-Tg-rg-T43718-Ab-1/ GM-Tg-rg-T43718-Ab-2; GM-Tg-mg-T43718-Ab-1/ GM-Tg-mg-T43718-Ab-2; GM-Tg-cynog-T43718-Ab-1/ GM-Tg-cynog-T43718-Ab-2; GM-Tg-felg-T43718-Ab-1/ GM-Tg-felg-T43718-Ab-2; GM-Tg-cang-T43718-Ab-1/ GM-Tg-cang-T43718-Ab-2; GM-Tg-bovg-T43718-Ab-1/ GM-Tg-bovg-T43718-Ab-2; GM-Tg-equg-T43718-Ab-1/ GM-Tg-equg-T43718-Ab-2 |
| Products Name | Anti-TLR5 monoclonal antibody |
| Format | mab |
| Target Name | TLR5 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-TLR5 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species TLR5/ MELIOS/ SLE1 VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | vGMAD000152 | human TLR5 Adenovirus particle |
| ORF Viral Vector | vGMLP003189 | human TLR5 Lentivirus particle |
| ORF Viral Vector | pGMLP003189 | human TLR5 Lentivirus plasmid |
| ORF Viral Vector | pGMAD000152 | human TLR5 Adenovirus plasmid |
| ORF Viral Vector | pGMLPm003108 | mouse Tlr5 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm003108 | mouse Tlr5 Lentivirus particle |
Target information
| Target ID | GM-T43718 |
| Target Name | TLR5 |
| Gene ID | 7100,53791,289337,574328,488605,101082202,444870,111771347 |
| Gene Symbol and Synonyms | MELIOS,SLE1,SLEB1,TIL3,TLR-5,TLR5 |
| Uniprot Accession | O60602 |
| Uniprot Entry Name | TLR5_HUMAN |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target, Immuno-oncology Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000187554 |
| Target Classification | Checkpoint-Immuno Oncology |
The target: TLR5, gene name: TLR5, also named as MELIOS, SLE1, SLEB1, TIL3. This gene encodes a member of the toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immune responses. These receptors recognize distinct pathogen-associated molecular patterns that are expressed on infectious agents. The protein encoded by this gene recognizes bacterial flagellin, the principal component of bacterial flagella and a virulence factor. The activation of this receptor mobilizes the nuclear factor NF-kappaB, which in turn activates a host of inflammatory-related target genes. Mutations in this gene have been associated with both resistance and susceptibility to systemic lupus erythematosus, and susceptibility to Legionnaire disease.[provided by RefSeq, Dec 2009].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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