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Anti-TPA/ PLAT/ T-PA functional antibody
Anti-TPA/ PLAT/ T-PA functional antibody for cell culture, ELISA & in-vivo assay
Go to PLAT/PLAT products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T45299-Ab-1/ GM-Tg-hg-T45299-Ab-2 | Anti-Human PLAT monoclonal antibody | Human |
| GM-Tg-rg-T45299-Ab-1/ GM-Tg-rg-T45299-Ab-2 | Anti-Rat PLAT monoclonal antibody | Rat |
| GM-Tg-mg-T45299-Ab-1/ GM-Tg-mg-T45299-Ab-2 | Anti-Mouse PLAT monoclonal antibody | Mouse |
| GM-Tg-cynog-T45299-Ab-1/ GM-Tg-cynog-T45299-Ab-2 | Anti-Cynomolgus/ Rhesus macaque PLAT monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T45299-Ab-1/ GM-Tg-felg-T45299-Ab-2 | Anti-Feline PLAT monoclonal antibody | Feline |
| GM-Tg-cang-T45299-Ab-1/ GM-Tg-cang-T45299-Ab-2 | Anti-Canine PLAT monoclonal antibody | Canine |
| GM-Tg-bovg-T45299-Ab-1/ GM-Tg-bovg-T45299-Ab-2 | Anti-Bovine PLAT monoclonal antibody | Bovine |
| GM-Tg-equg-T45299-Ab-1/ GM-Tg-equg-T45299-Ab-2 | Anti-Equine PLAT monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T45299-Ab-1/ GM-Tg-hg-T45299-Ab-2; GM-Tg-rg-T45299-Ab-1/ GM-Tg-rg-T45299-Ab-2; GM-Tg-mg-T45299-Ab-1/ GM-Tg-mg-T45299-Ab-2; GM-Tg-cynog-T45299-Ab-1/ GM-Tg-cynog-T45299-Ab-2; GM-Tg-felg-T45299-Ab-1/ GM-Tg-felg-T45299-Ab-2; GM-Tg-cang-T45299-Ab-1/ GM-Tg-cang-T45299-Ab-2; GM-Tg-bovg-T45299-Ab-1/ GM-Tg-bovg-T45299-Ab-2; GM-Tg-equg-T45299-Ab-1/ GM-Tg-equg-T45299-Ab-2 |
| Products Name | Anti-PLAT monoclonal antibody |
| Format | mab |
| Target Name | PLAT |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-PLAT benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T45299-Ag-1 | Recombinant multi-species TPA/ PLAT/ T-PA protein |
| ORF Viral Vector | vGMAP000332 | Human PLAT Adenovirus particle |
| ORF Viral Vector | pGMLP001986 | human PLAT Lentivirus plasmid |
| ORF Viral Vector | vGMLP001986 | human PLAT Lentivirus particle |
| ORF Viral Vector | pGMAP000332 | Human PLAT Adenovirus plasmid |
| ORF Viral Vector | pGMLPm002725 | mouse Plat Lentivirus plasmid |
| ORF Viral Vector | vGMLPm002725 | mouse Plat Lentivirus particle |
Target information
| Target ID | GM-T45299 |
| Target Name | PLAT |
| Gene ID | 5327,18791,25692,704475,482840,101100299,281407,100050239 |
| Gene Symbol and Synonyms | D8Ertd2e,PATISS,PLAT,T-PA,TPA |
| Uniprot Accession | P00750,P19637,Q28198 |
| Uniprot Entry Name | TPA_HUMAN,TPA_RAT,TPA_BOVIN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | Therapeutics Target |
| Disease | Cancer |
| Gene Ensembl | ENSG00000104368 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: PLAT, gene name: PLAT, also named as T-PA, TPA. This gene encodes tissue-type plasminogen activator, a secreted serine protease that converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. The encoded preproprotein is proteolytically processed by plasmin or trypsin to generate heavy and light chains. These chains associate via disulfide linkages to form the heterodimeric enzyme. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding, while decreased activity leads to hypofibrinolysis, which can result in thrombosis or embolism. Alternative splicing of this gene results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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