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Anti-TNF12/ TWEAK/ TNFSF12 monoclonal antibody
Anti-TNF12/ TWEAK/ TNFSF12 antibody for FACS & in-vivo assay
Go to TWEAK/TNFSF12 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T46524-Ab-1/ GM-Tg-hg-T46524-Ab-2 | Anti-Human TWEAK/TNFSF12 monoclonal antibody | Human |
| GM-Tg-rg-T46524-Ab-1/ GM-Tg-rg-T46524-Ab-2 | Anti-Rat TWEAK/TNFSF12 monoclonal antibody | Rat |
| GM-Tg-mg-T46524-Ab-1/ GM-Tg-mg-T46524-Ab-2 | Anti-Mouse TWEAK/TNFSF12 monoclonal antibody | Mouse |
| GM-Tg-cynog-T46524-Ab-1/ GM-Tg-cynog-T46524-Ab-2 | Anti-Cynomolgus/ Rhesus macaque TWEAK/TNFSF12 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T46524-Ab-1/ GM-Tg-felg-T46524-Ab-2 | Anti-Feline TWEAK/TNFSF12 monoclonal antibody | Feline |
| GM-Tg-cang-T46524-Ab-1/ GM-Tg-cang-T46524-Ab-2 | Anti-Canine TWEAK/TNFSF12 monoclonal antibody | Canine |
| GM-Tg-bovg-T46524-Ab-1/ GM-Tg-bovg-T46524-Ab-2 | Anti-Bovine TWEAK/TNFSF12 monoclonal antibody | Bovine |
| GM-Tg-equg-T46524-Ab-1/ GM-Tg-equg-T46524-Ab-2 | Anti-Equine TWEAK/TNFSF12 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T46524-Ab-1/ GM-Tg-hg-T46524-Ab-2; GM-Tg-rg-T46524-Ab-1/ GM-Tg-rg-T46524-Ab-2; GM-Tg-mg-T46524-Ab-1/ GM-Tg-mg-T46524-Ab-2; GM-Tg-cynog-T46524-Ab-1/ GM-Tg-cynog-T46524-Ab-2; GM-Tg-felg-T46524-Ab-1/ GM-Tg-felg-T46524-Ab-2; GM-Tg-cang-T46524-Ab-1/ GM-Tg-cang-T46524-Ab-2; GM-Tg-bovg-T46524-Ab-1/ GM-Tg-bovg-T46524-Ab-2; GM-Tg-equg-T46524-Ab-1/ GM-Tg-equg-T46524-Ab-2 |
| Products Name | Anti-TWEAK/TNFSF12 monoclonal antibody |
| Format | mab |
| Target Name | TWEAK |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-TWEAK benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species TNF12/ TWEAK/ TNFSF12 VLP (virus-like particle) (Products Developing) |
| Cytokine | GM-Tg-g-T46524-Ag-1 | Tumor necrosis factor superfamily member 12 (TNFSF12) protein |
| ORF Viral Vector | vGMLP002011 | human TNFSF12 Lentivirus particle |
| ORF Viral Vector | pGMLP002011 | human TNFSF12 Lentivirus plasmid |
| ORF Viral Vector | pGMLPm000992 | mouse Tnfsf12 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm000992 | mouse Tnfsf12 Lentivirus particle |
Target information
| Target ID | GM-T46524 |
| Target Name | TWEAK |
| Gene ID | 8742,360548,100551513,100061872 |
| Gene Symbol and Synonyms | APO3L,DR3LG,TNFSF12,TNLG4A,TWEAK |
| Uniprot Accession | O43508 |
| Uniprot Entry Name | TNF12_HUMAN |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target, Cytokine Target |
| Disease | Prostate Cancer |
| Gene Ensembl | ENSG00000239697 |
| Target Classification | N/A |
The target: TWEAK, gene name: TNFSF12, also named as APO3L, DR3LG, TNLG4A, TWEAK. The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is a ligand for the FN14/TWEAKR receptor. This cytokine has overlapping signaling functions with TNF, but displays a much wider tissue distribution. This cytokine, which exists in both membrane-bound and secreted forms, can induce apoptosis via multiple pathways of cell death in a cell type-specific manner. This cytokine is also found to promote proliferation and migration of endothelial cells, and thus acts as a regulator of angiogenesis. Alternative splicing results in multiple transcript variants. Some transcripts skip the last exon of this gene and continue into the second exon of the neighboring TNFSF13 gene; such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13. [provided by RefSeq, Oct 2010].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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