Anti-AURKB monoclonal antibody

Pre-made anti-AURKB monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research

Target products collectionGo to AURKB/AURKB products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)


Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T46781-Ab-1/ GM-Tg-hg-T46781-Ab-2Anti-Human AURKB monoclonal antibodyHuman
GM-Tg-rg-T46781-Ab-1/ GM-Tg-rg-T46781-Ab-2Anti-Rat AURKB monoclonal antibodyRat
GM-Tg-mg-T46781-Ab-1/ GM-Tg-mg-T46781-Ab-2Anti-Mouse AURKB monoclonal antibodyMouse
GM-Tg-cynog-T46781-Ab-1/ GM-Tg-cynog-T46781-Ab-2Anti-Cynomolgus/ Rhesus macaque AURKB monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T46781-Ab-1/ GM-Tg-felg-T46781-Ab-2Anti-Feline AURKB monoclonal antibodyFeline
GM-Tg-cang-T46781-Ab-1/ GM-Tg-cang-T46781-Ab-2Anti-Canine AURKB monoclonal antibodyCanine
GM-Tg-bovg-T46781-Ab-1/ GM-Tg-bovg-T46781-Ab-2Anti-Bovine AURKB monoclonal antibodyBovine
GM-Tg-equg-T46781-Ab-1/ GM-Tg-equg-T46781-Ab-2Anti-Equine AURKB monoclonal antibodyEquine

Size: 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T46781-Ab-1/ GM-Tg-hg-T46781-Ab-2; GM-Tg-rg-T46781-Ab-1/ GM-Tg-rg-T46781-Ab-2;
GM-Tg-mg-T46781-Ab-1/ GM-Tg-mg-T46781-Ab-2; GM-Tg-cynog-T46781-Ab-1/ GM-Tg-cynog-T46781-Ab-2;
GM-Tg-felg-T46781-Ab-1/ GM-Tg-felg-T46781-Ab-2; GM-Tg-cang-T46781-Ab-1/ GM-Tg-cang-T46781-Ab-2;
GM-Tg-bovg-T46781-Ab-1/ GM-Tg-bovg-T46781-Ab-2; GM-Tg-equg-T46781-Ab-1/ GM-Tg-equg-T46781-Ab-2
Products NameAnti-AURKB monoclonal antibody
Formatmab
Target NameAURKB
Protein Sub-locationIntrocelluar Protein
Category of antibodyTherapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)
IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected.
TagFc
Products descriptionPre-made anti-AURKB monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


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    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-T46781-Ag-1Recombinant multi-species AURKB/ AIK2/ AIM-1 protein
    ORF Viral VectorpGMLPm001440mouse Aurkb Lentivirus plasmid
    ORF Viral VectorvGMLPm001440mouse Aurkb Lentivirus particle


    Target information

    Target IDGM-T46781
    Target NameAURKB
    Gene ID9212,20877,114592,721955,479492,101081264,360192,100073050
    Gene Symbol and SynonymsAIK2,AIM-1,AIM1,AIRK2,ARK-2,ARK2,AurB,AURKB,aurkb-sv1,aurkb-sv2,IPL1,PPP1R48,STK-1,STK12,STK5
    Uniprot AccessionQ96GD4,O55099,Q7YRC6
    Uniprot Entry NameAURKB_HUMAN,AURKB_RAT,AURKB_BOVIN
    Protein Sub-locationIntrocelluar Protein
    CategoryTherapeutics Target
    DiseaseCancer
    Gene EnsemblENSG00000178999
    Target ClassificationKinase, Tumor-associated antigen (TAA)

    The target: AURKB, gene name: AURKB, also named as AIK2, AIM-1, AIM1, ARK-2, ARK2, AurB, IPL1, PPP1R48, STK-1, STK12, STK5, aurkb-sv1, aurkb-sv2. This gene encodes a member of the aurora kinase subfamily of serine/threonine kinases. The genes encoding the other two members of this subfamily are located on chromosomes 19 and 20. These kinases participate in the regulation of alignment and segregation of chromosomes during mitosis and meiosis through association with microtubules. A pseudogene of this gene is located on chromosome 8. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2015].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.