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Anti-AVR2A/ ACVR2A/ ACTRII monoclonal antibody
Anti-AVR2A/ ACVR2A/ ACTRII antibody for FACS & in-vivo assay
Go to ACVR2A/ACVR2A products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T47366-Ab-1/ GM-Tg-hg-T47366-Ab-2 | Anti-Human ACVR2A monoclonal antibody | Human |
| GM-Tg-rg-T47366-Ab-1/ GM-Tg-rg-T47366-Ab-2 | Anti-Rat ACVR2A monoclonal antibody | Rat |
| GM-Tg-mg-T47366-Ab-1/ GM-Tg-mg-T47366-Ab-2 | Anti-Mouse ACVR2A monoclonal antibody | Mouse |
| GM-Tg-cynog-T47366-Ab-1/ GM-Tg-cynog-T47366-Ab-2 | Anti-Cynomolgus/ Rhesus macaque ACVR2A monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T47366-Ab-1/ GM-Tg-felg-T47366-Ab-2 | Anti-Feline ACVR2A monoclonal antibody | Feline |
| GM-Tg-cang-T47366-Ab-1/ GM-Tg-cang-T47366-Ab-2 | Anti-Canine ACVR2A monoclonal antibody | Canine |
| GM-Tg-bovg-T47366-Ab-1/ GM-Tg-bovg-T47366-Ab-2 | Anti-Bovine ACVR2A monoclonal antibody | Bovine |
| GM-Tg-equg-T47366-Ab-1/ GM-Tg-equg-T47366-Ab-2 | Anti-Equine ACVR2A monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T47366-Ab-1/ GM-Tg-hg-T47366-Ab-2; GM-Tg-rg-T47366-Ab-1/ GM-Tg-rg-T47366-Ab-2; GM-Tg-mg-T47366-Ab-1/ GM-Tg-mg-T47366-Ab-2; GM-Tg-cynog-T47366-Ab-1/ GM-Tg-cynog-T47366-Ab-2; GM-Tg-felg-T47366-Ab-1/ GM-Tg-felg-T47366-Ab-2; GM-Tg-cang-T47366-Ab-1/ GM-Tg-cang-T47366-Ab-2; GM-Tg-bovg-T47366-Ab-1/ GM-Tg-bovg-T47366-Ab-2; GM-Tg-equg-T47366-Ab-1/ GM-Tg-equg-T47366-Ab-2 |
| Products Name | Anti-ACVR2A monoclonal antibody |
| Format | mab |
| Target Name | ACVR2A |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-ACVR2A benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species AVR2A/ ACVR2A/ ACTRII VLP (virus-like particle) (Products Developing) |
| Cytokine | GM-Tg-g-T47366-Ag-1 | activin A receptor, type IIA (ACVR2A) protein |
| ORF Viral Vector | pGMLP004152 | human ACVR2A Lentivirus plasmid |
| ORF Viral Vector | vGMLP004152 | human ACVR2A Lentivirus particle |
| ORF Viral Vector | pGMLPm004265 | mouse Acvr2a Lentivirus plasmid |
| ORF Viral Vector | vGMLPm004265 | mouse Acvr2a Lentivirus particle |
Target information
| Target ID | GM-T47366 |
| Target Name | ACVR2A |
| Gene ID | 92,11480,29263,707017,476140,101097750,281598,100049823 |
| Gene Symbol and Synonyms | ACTRII,ActrIIa,ACVR2,ACVR2A,rActR-II,TactrII |
| Uniprot Accession | P27037,P38444,Q28043 |
| Uniprot Entry Name | AVR2A_HUMAN,AVR2A_RAT,AVR2A_BOVIN |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target, Cytokine Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000121989 |
| Target Classification | Kinase |
The target: ACVR2A, gene name: ACVR2A, also named as ACTRII, ACVR2. This gene encodes a receptor that mediates the functions of activins, which are members of the transforming growth factor-beta (TGF-beta) superfamily involved in diverse biological processes. The encoded protein is a transmembrane serine-threonine kinase receptor which mediates signaling by forming heterodimeric complexes with various combinations of type I and type II receptors and ligands in a cell-specific manner. The encoded type II receptor is primarily involved in ligand-binding and includes an extracellular ligand-binding domain, a transmembrane domain and a cytoplasmic serine-threonine kinase domain. This gene may be associated with susceptibility to preeclampsia, a pregnancy-related disease which can result in maternal and fetal morbidity and mortality. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jun 2013].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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