Anti-EPCAM/ DIAR5/ EGP-2 monoclonal antibody

Anti-EPCAM/ DIAR5/ EGP-2 antibody for FACS & in-vivo assay

Target products collectionGo to EPCAM/EPCAM products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T47863-Ab-1/ GM-Tg-hg-T47863-Ab-2Anti-Human EPCAM monoclonal antibodyHuman
GM-Tg-rg-T47863-Ab-1/ GM-Tg-rg-T47863-Ab-2Anti-Rat EPCAM monoclonal antibodyRat
GM-Tg-mg-T47863-Ab-1/ GM-Tg-mg-T47863-Ab-2Anti-Mouse EPCAM monoclonal antibodyMouse
GM-Tg-cynog-T47863-Ab-1/ GM-Tg-cynog-T47863-Ab-2Anti-Cynomolgus/ Rhesus macaque EPCAM monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T47863-Ab-1/ GM-Tg-felg-T47863-Ab-2Anti-Feline EPCAM monoclonal antibodyFeline
GM-Tg-cang-T47863-Ab-1/ GM-Tg-cang-T47863-Ab-2Anti-Canine EPCAM monoclonal antibodyCanine
GM-Tg-bovg-T47863-Ab-1/ GM-Tg-bovg-T47863-Ab-2Anti-Bovine EPCAM monoclonal antibodyBovine
GM-Tg-equg-T47863-Ab-1/ GM-Tg-equg-T47863-Ab-2Anti-Equine EPCAM monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T47863-Ab-1/ GM-Tg-hg-T47863-Ab-2; GM-Tg-rg-T47863-Ab-1/ GM-Tg-rg-T47863-Ab-2;
GM-Tg-mg-T47863-Ab-1/ GM-Tg-mg-T47863-Ab-2; GM-Tg-cynog-T47863-Ab-1/ GM-Tg-cynog-T47863-Ab-2;
GM-Tg-felg-T47863-Ab-1/ GM-Tg-felg-T47863-Ab-2; GM-Tg-cang-T47863-Ab-1/ GM-Tg-cang-T47863-Ab-2;
GM-Tg-bovg-T47863-Ab-1/ GM-Tg-bovg-T47863-Ab-2; GM-Tg-equg-T47863-Ab-1/ GM-Tg-equg-T47863-Ab-2
Products NameAnti-EPCAM monoclonal antibody
Formatmab
Target NameEPCAM
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-EPCAM benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


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    Associated products


    CategoryCat No.Products Name
    BiosimilarGMP-Bios-ab-107Pre-Made Citatuzumab biosimilar, Fab Fusion, Anti-EPCAM Antibody: Anti-Ber-Ep4/BerEp4/DIAR5/EGP-2/EGP314/EGP40/ESA/HNPCC8/KS1/4/KSA/M4S1/MIC18/MK-1/MOC-31/TACSTD1/TROP1 therapeutic antibody
    BiosimilarGMP-Bios-INN-781Pre-Made Citatuzumab Bogatox biosimilar, Fusion Protein, Citatuzumab-Anti-EPCAM Antibody: Anti-Ber-Ep4/BerEp4/DIAR5/EGP-2/EGP314/EGP40/ESA/HNPCC8/KS1/4/KSA/M4S1/MIC18/MK-1/MOC-31/TACSTD1/TROP1 therapeutic antibody fused with Bougainvillea spectabilis Willd bouganin
    BiosimilarGMP-Bios-INN-772Pre-Made Catumaxomab Biosimilar, Bispecific, Anti-Cd3E; Epcam Antibody: Anti-T3E/TCRE/IMD18/CD3epsilon;Ber-Ep4/BerEp4/DIAR5/EGP-2/EGP314/EGP40/ESA/HNPCC8/KS1/4/KSA/M4S1/MIC18/MK-1/MOC-31/TACSTD1/TROP1 therapeutic antibody
    BiosimilarGMP-Bios-ab-408Pre-Made Oportuzumab biosimilar, scFv, Anti-EPCAM Antibody: Anti-Ber-Ep4/BerEp4/DIAR5/EGP-2/EGP314/EGP40/ESA/HNPCC8/KS1/4/KSA/M4S1/MIC18/MK-1/MOC-31/TACSTD1/TROP1 therapeutic antibody
    BiosimilarGMP-Bios-INN-719Pre-Made Adecatumumab Biosimilar, Whole Mab, Anti-Epcam Antibody: Anti-Ber-Ep4/BerEp4/DIAR5/EGP-2/EGP314/EGP40/ESA/HNPCC8/KS1/4/KSA/M4S1/MIC18/MK-1/MOC-31/TACSTD1/TROP1 therapeutic antibody
    BiosimilarGMP-Bios-ab-165Pre-Made Edrecolomab biosimilar, Whole mAb, Anti-EPCAM Antibody: Anti-Ber-Ep4/BerEp4/DIAR5/EGP-2/EGP314/EGP40/ESA/HNPCC8/KS1/4/KSA/M4S1/MIC18/MK-1/MOC-31/TACSTD1/TROP1 therapeutic antibody
    BiosimilarGMP-Bios-INN-939Pre-Made Oportuzumab Monatox biosimilar, Fusion Protein, Oportuzumab-Anti-EPCAM Antibody: Anti-Ber-Ep4/BerEp4/DIAR5/EGP-2/EGP314/EGP40/ESA/HNPCC8/KS1/4/KSA/M4S1/MIC18/MK-1/MOC-31/TACSTD1/TROP1 therapeutic antibody fused with Pseudomonas aeruginosa exotoxin A
    BiosimilarGMP-Bios-ab-528Pre-Made Solitomab biosimilar, Bispecific scFv, Anti-EPCAM;CD3E Antibody: Anti-Ber-Ep4/BerEp4/DIAR5/EGP-2/EGP314/EGP40/ESA/HNPCC8/KS1/4/KSA/M4S1/MIC18/MK-1/MOC-31/TACSTD1/TROP1;T3E/TCRE/IMD18 therapeutic antibody
    BiosimilarGMP-Bios-INN-1035Pre-Made Tucotuzumab Celmoleukin biosimilar, Fusion Protein, Tucotuzumab-Anti-EPCAM Antibody: Anti-Ber-Ep4/BerEp4/DIAR5/EGP-2/EGP314/EGP40/ESA/HNPCC8/KS1/4/KSA/M4S1/MIC18/MK-1/MOC-31/TACSTD1/TROP1 therapeutic antibody fused with human IL2 (interleukin 2, IL-2) Pr21-153
    Target AntigenProducts DevelopingMulti-species EPCAM/ DIAR5/ EGP-2 VLP (virus-like particle) (Products Developing)
    ORF Viral VectorpGMLV000875human EPCAM Lentivirus plasmid
    ORF Viral VectorvGMAAV000236human EPCAM AAV particle
    ORF Viral VectorpGMLV000293human EPCAM Lentivirus plasmid
    ORF Viral VectorvGMLV000293human EPCAM Lentivirus particle
    ORF Viral VectorvGMLV000875human EPCAM Lentivirus particle
    ORF Viral VectorpGMAAV000236human EPCAM AAV plasmid
    ORF Viral VectorpGMAP000558Human EPCAM Adenovirus plasmid
    ORF Viral VectorpGMAAV000214human EpCAM AAV plasmid
    ORF Viral VectorvGMAP000558Human EPCAM Adenovirus particle
    ORF Viral VectorvGMAAV000214human EpCAM AAV particle
    ORF Viral VectorpGMLPm002282mouse Epcam Lentivirus plasmid
    ORF Viral VectorvGMLPm002282mouse Epcam Lentivirus particle


    Target information

    Target IDGM-T47863
    Target NameEPCAM
    Gene ID4072,17075,171577,677680,481360,101081794,514039,100053148
    Gene Symbol and SynonymsBer-Ep4,BerEp4,CD326,DIAR5,EGP,EGP-2,EGP314,EGP40,Ep-CAM,EPCAM,EpCAM1,ESA,GA733-2,gp40,HNPCC8,KS1/4,KSA,Ly74,LYNCH8,M4S1,MIC18,MK-1,MOC-31,Tacsd1,TACSTD1,TROP1
    Uniprot AccessionP16422,O55159,Q1WER1,Q3T0L5
    Uniprot Entry NameEPCAM_HUMAN,EPCAM_MACMU,EPCAM_RAT,EPCAM_BOVIN
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target, Immuno-oncology Target, INN Index
    DiseaseOvary Cancer
    Gene EnsemblENSG00000119888
    Target ClassificationCheckpoint-Immuno Oncology

    The target: EPCAM, gene name: EPCAM, also named as DIAR5, EGP-2, EGP314, EGP40, ESA, HNPCC8, KS1/4, KSA, M4S1, MIC18, MK-1, TACSTD1, TROP1. This gene encodes a carcinoma-associated antigen and is a member of a family that includes at least two type I membrane proteins. This antigen is expressed on most normal epithelial cells and gastrointestinal carcinomas and functions as a homotypic calcium-independent cell adhesion molecule. The antigen is being used as a target for immunotherapy treatment of human carcinomas. Mutations in this gene result in congenital tufting enteropathy. [provided by RefSeq, Dec 2008].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.