Anti-PTN2/ PTPN2/ PTPT monoclonal antibody

Anti-PTN2/ PTPN2/ PTPT antibody for FACS & in-vivo assay

Target products collectionGo to PTPN2/PTPN2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)


Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T49156-Ab-1/ GM-Tg-hg-T49156-Ab-2Anti-Human PTPN2 monoclonal antibodyHuman
GM-Tg-rg-T49156-Ab-1/ GM-Tg-rg-T49156-Ab-2Anti-Rat PTPN2 monoclonal antibodyRat
GM-Tg-mg-T49156-Ab-1/ GM-Tg-mg-T49156-Ab-2Anti-Mouse PTPN2 monoclonal antibodyMouse
GM-Tg-cynog-T49156-Ab-1/ GM-Tg-cynog-T49156-Ab-2Anti-Cynomolgus/ Rhesus macaque PTPN2 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T49156-Ab-1/ GM-Tg-felg-T49156-Ab-2Anti-Feline PTPN2 monoclonal antibodyFeline
GM-Tg-cang-T49156-Ab-1/ GM-Tg-cang-T49156-Ab-2Anti-Canine PTPN2 monoclonal antibodyCanine
GM-Tg-bovg-T49156-Ab-1/ GM-Tg-bovg-T49156-Ab-2Anti-Bovine PTPN2 monoclonal antibodyBovine
GM-Tg-equg-T49156-Ab-1/ GM-Tg-equg-T49156-Ab-2Anti-Equine PTPN2 monoclonal antibodyEquine

Size: 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T49156-Ab-1/ GM-Tg-hg-T49156-Ab-2; GM-Tg-rg-T49156-Ab-1/ GM-Tg-rg-T49156-Ab-2;
GM-Tg-mg-T49156-Ab-1/ GM-Tg-mg-T49156-Ab-2; GM-Tg-cynog-T49156-Ab-1/ GM-Tg-cynog-T49156-Ab-2;
GM-Tg-felg-T49156-Ab-1/ GM-Tg-felg-T49156-Ab-2; GM-Tg-cang-T49156-Ab-1/ GM-Tg-cang-T49156-Ab-2;
GM-Tg-bovg-T49156-Ab-1/ GM-Tg-bovg-T49156-Ab-2; GM-Tg-equg-T49156-Ab-1/ GM-Tg-equg-T49156-Ab-2
Products NameAnti-PTPN2 monoclonal antibody
Formatmab
Target NamePTPN2
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)
IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-PTPN2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species PTN2/ PTPN2/ PTPT VLP (virus-like particle) (Products Developing)
    ORF Viral VectorpGMAD000060mouse Ptpn2 Adenovirus plasmid
    ORF Viral VectorvGMAD000060mouse Ptpn2 Adenovirus particle


    Target information

    Target IDGM-T49156
    Target NamePTPN2
    Gene ID5771,19255,117063,114673846,490563,101095923,540888,100057795
    Gene Symbol and SynonymsPTN2,PTPN2,PTPT,TC-PTP,TCELLPTP,TCPTP
    Uniprot AccessionP17706,P35233
    Uniprot Entry NamePTN2_HUMAN,PTN2_RAT
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target
    DiseaseN/A
    Gene EnsemblENSG00000175354
    Target ClassificationN/A

    The target: PTPN2, gene name: PTPN2, also named as PTN2, PTPT, TC-PTP, TCELLPTP, TCPTP. The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Epidermal growth factor receptor and the adaptor protein Shc were reported to be substrates of this PTP, which suggested the roles in growth factor mediated cell signaling. Multiple alternatively spliced transcript variants encoding different isoforms have been found. Two highly related but distinctly processed pseudogenes that localize to chromosomes 1 and 13, respectively, have been reported. [provided by RefSeq, May 2011].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.