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Anti-PIM1 monoclonal antibody
Pre-made anti-PIM1 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to PIM1/PIM1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T50594-Ab-1/ GM-Tg-hg-T50594-Ab-2 | Anti-Human PIM1 monoclonal antibody | Human |
| GM-Tg-rg-T50594-Ab-1/ GM-Tg-rg-T50594-Ab-2 | Anti-Rat PIM1 monoclonal antibody | Rat |
| GM-Tg-mg-T50594-Ab-1/ GM-Tg-mg-T50594-Ab-2 | Anti-Mouse PIM1 monoclonal antibody | Mouse |
| GM-Tg-cynog-T50594-Ab-1/ GM-Tg-cynog-T50594-Ab-2 | Anti-Cynomolgus/ Rhesus macaque PIM1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T50594-Ab-1/ GM-Tg-felg-T50594-Ab-2 | Anti-Feline PIM1 monoclonal antibody | Feline |
| GM-Tg-cang-T50594-Ab-1/ GM-Tg-cang-T50594-Ab-2 | Anti-Canine PIM1 monoclonal antibody | Canine |
| GM-Tg-bovg-T50594-Ab-1/ GM-Tg-bovg-T50594-Ab-2 | Anti-Bovine PIM1 monoclonal antibody | Bovine |
| GM-Tg-equg-T50594-Ab-1/ GM-Tg-equg-T50594-Ab-2 | Anti-Equine PIM1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T50594-Ab-1/ GM-Tg-hg-T50594-Ab-2; GM-Tg-rg-T50594-Ab-1/ GM-Tg-rg-T50594-Ab-2; GM-Tg-mg-T50594-Ab-1/ GM-Tg-mg-T50594-Ab-2; GM-Tg-cynog-T50594-Ab-1/ GM-Tg-cynog-T50594-Ab-2; GM-Tg-felg-T50594-Ab-1/ GM-Tg-felg-T50594-Ab-2; GM-Tg-cang-T50594-Ab-1/ GM-Tg-cang-T50594-Ab-2; GM-Tg-bovg-T50594-Ab-1/ GM-Tg-bovg-T50594-Ab-2; GM-Tg-equg-T50594-Ab-1/ GM-Tg-equg-T50594-Ab-2 |
| Products Name | Anti-PIM1 monoclonal antibody |
| Format | mab |
| Target Name | PIM1 |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-PIM1 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T50594-Ag-1 | Recombinant multi-species PIM1/ PIM protein |
| ORF Viral Vector | pGMAP000309 | Human PIM1 Adenovirus plasmid |
| ORF Viral Vector | vGMAP000309 | Human PIM1 Adenovirus particle |
| ORF Viral Vector | pGMLV000107 | rat Pim1 Lentivirus plasmid |
| ORF Viral Vector | pGMAAV000309 | house mouse Pim1 AAV plasmid |
| ORF Viral Vector | pGMLPm001265 | mouse Pim1 Lentivirus plasmid |
| ORF Viral Vector | vGMLV000107 | rat Pim1 Lentivirus particle |
| ORF Viral Vector | vGMAAV000309 | house mouse Pim1 AAV particle |
| ORF Viral Vector | vGMLPm001265 | mouse Pim1 Lentivirus particle |
Target information
| Target ID | GM-T50594 |
| Target Name | PIM1 |
| Gene ID | 5292,18712,24649,114677751,493888,281402,100053898 |
| Gene Symbol and Synonyms | PIM,Pim-1,PIM1 |
| Uniprot Accession | P11309,P26794,Q95LJ0,Q9N0P9 |
| Uniprot Entry Name | PIM1_HUMAN,PIM1_RAT,PIM1_FELCA,PIM1_BOVIN |
| Protein Sub-location | Introcelluar Protein |
| Category | Therapeutics Target |
| Disease | Cancer |
| Gene Ensembl | ENSG00000137193 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: PIM1, gene name: PIM1, also named as PIM. The protein encoded by this gene belongs to the Ser/Thr protein kinase family, and PIM subfamily. This gene is expressed primarily in B-lymphoid and myeloid cell lines, and is overexpressed in hematopoietic malignancies and in prostate cancer. It plays a role in signal transduction in blood cells, contributing to both cell proliferation and survival, and thus provides a selective advantage in tumorigenesis. Both the human and orthologous mouse genes have been reported to encode two isoforms (with preferential cellular localization) resulting from the use of alternative in-frame translation initiation codons, the upstream non-AUG (CUG) and downstream AUG codons (PMIDs:16186805, 1825810).[provided by RefSeq, Aug 2011].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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