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Anti-NTRK3/ TrkC/ GP145-TrkC monoclonal antibody
Anti-NTRK3/ TrkC/ GP145-TrkC antibody for FACS & in-vivo assay
Go to TrkC/NTRK3 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T51076-Ab-1/ GM-Tg-hg-T51076-Ab-2 | Anti-Human TrkC/NTRK3 monoclonal antibody | Human |
| GM-Tg-rg-T51076-Ab-1/ GM-Tg-rg-T51076-Ab-2 | Anti-Rat TrkC/NTRK3 monoclonal antibody | Rat |
| GM-Tg-mg-T51076-Ab-1/ GM-Tg-mg-T51076-Ab-2 | Anti-Mouse TrkC/NTRK3 monoclonal antibody | Mouse |
| GM-Tg-cynog-T51076-Ab-1/ GM-Tg-cynog-T51076-Ab-2 | Anti-Cynomolgus/ Rhesus macaque TrkC/NTRK3 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T51076-Ab-1/ GM-Tg-felg-T51076-Ab-2 | Anti-Feline TrkC/NTRK3 monoclonal antibody | Feline |
| GM-Tg-cang-T51076-Ab-1/ GM-Tg-cang-T51076-Ab-2 | Anti-Canine TrkC/NTRK3 monoclonal antibody | Canine |
| GM-Tg-bovg-T51076-Ab-1/ GM-Tg-bovg-T51076-Ab-2 | Anti-Bovine TrkC/NTRK3 monoclonal antibody | Bovine |
| GM-Tg-equg-T51076-Ab-1/ GM-Tg-equg-T51076-Ab-2 | Anti-Equine TrkC/NTRK3 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T51076-Ab-1/ GM-Tg-hg-T51076-Ab-2; GM-Tg-rg-T51076-Ab-1/ GM-Tg-rg-T51076-Ab-2; GM-Tg-mg-T51076-Ab-1/ GM-Tg-mg-T51076-Ab-2; GM-Tg-cynog-T51076-Ab-1/ GM-Tg-cynog-T51076-Ab-2; GM-Tg-felg-T51076-Ab-1/ GM-Tg-felg-T51076-Ab-2; GM-Tg-cang-T51076-Ab-1/ GM-Tg-cang-T51076-Ab-2; GM-Tg-bovg-T51076-Ab-1/ GM-Tg-bovg-T51076-Ab-2; GM-Tg-equg-T51076-Ab-1/ GM-Tg-equg-T51076-Ab-2 |
| Products Name | Anti-TrkC/NTRK3 monoclonal antibody |
| Format | mab |
| Target Name | TrkC |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-TrkC benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species NTRK3/ TrkC/ GP145-TrkC VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | vGMLV000469 | human NTRK3 Lentivirus particle |
| ORF Viral Vector | pGMLV000469 | human NTRK3 Lentivirus plasmid |
| ORF Viral Vector | pGMAD000101 | rat Ntrk3 Adenovirus plasmid |
| ORF Viral Vector | pGMLPm003577 | mouse Ntrk3 Lentivirus plasmid |
| ORF Viral Vector | vGMAD000101 | rat Ntrk3 Adenovirus particle |
| ORF Viral Vector | vGMLPm003577 | mouse Ntrk3 Lentivirus particle |
Target information
| Target ID | GM-T51076 |
| Target Name | TrkC |
| Gene ID | 4916,18213,29613,697615,100856261,101085548,539126,100069852 |
| Gene Symbol and Synonyms | gp145(trkC),GP145-TrkC,NTRK3,Ntrk3_tv3,TRKC |
| Uniprot Accession | Q16288,Q03351 |
| Uniprot Entry Name | NTRK3_HUMAN,NTRK3_RAT |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target |
| Disease | Cancer |
| Gene Ensembl | ENSG00000140538 |
| Target Classification | Kinase, Tumor-associated antigen (TAA) |
The target: TrkC, gene name: NTRK3, also named as GP145-TrkC, TRKC, gp145(trkC). This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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