Anti-OTC monoclonal antibody

Pre-made anti-OTC monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research

Target products collectionGo to OTC/OTC products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)


Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T52098-Ab-1/ GM-Tg-hg-T52098-Ab-2Anti-Human OTC monoclonal antibodyHuman
GM-Tg-rg-T52098-Ab-1/ GM-Tg-rg-T52098-Ab-2Anti-Rat OTC monoclonal antibodyRat
GM-Tg-mg-T52098-Ab-1/ GM-Tg-mg-T52098-Ab-2Anti-Mouse OTC monoclonal antibodyMouse
GM-Tg-cynog-T52098-Ab-1/ GM-Tg-cynog-T52098-Ab-2Anti-Cynomolgus/ Rhesus macaque OTC monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T52098-Ab-1/ GM-Tg-felg-T52098-Ab-2Anti-Feline OTC monoclonal antibodyFeline
GM-Tg-cang-T52098-Ab-1/ GM-Tg-cang-T52098-Ab-2Anti-Canine OTC monoclonal antibodyCanine
GM-Tg-bovg-T52098-Ab-1/ GM-Tg-bovg-T52098-Ab-2Anti-Bovine OTC monoclonal antibodyBovine
GM-Tg-equg-T52098-Ab-1/ GM-Tg-equg-T52098-Ab-2Anti-Equine OTC monoclonal antibodyEquine

Size: 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T52098-Ab-1/ GM-Tg-hg-T52098-Ab-2; GM-Tg-rg-T52098-Ab-1/ GM-Tg-rg-T52098-Ab-2;
GM-Tg-mg-T52098-Ab-1/ GM-Tg-mg-T52098-Ab-2; GM-Tg-cynog-T52098-Ab-1/ GM-Tg-cynog-T52098-Ab-2;
GM-Tg-felg-T52098-Ab-1/ GM-Tg-felg-T52098-Ab-2; GM-Tg-cang-T52098-Ab-1/ GM-Tg-cang-T52098-Ab-2;
GM-Tg-bovg-T52098-Ab-1/ GM-Tg-bovg-T52098-Ab-2; GM-Tg-equg-T52098-Ab-1/ GM-Tg-equg-T52098-Ab-2
Products NameAnti-OTC monoclonal antibody
Formatmab
Target NameOTC
Protein Sub-locationIntrocelluar Protein
Category of antibodyTherapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)
IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected.
TagFc
Products descriptionPre-made anti-OTC monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-T52098-Ag-1Recombinant multi-species OTC/ OCTD protein
    ORF Viral VectorpGMLPm001494mouse Otc Lentivirus plasmid
    ORF Viral VectorvGMLPm001494mouse Otc Lentivirus particle


    Target information

    Target IDGM-T52098
    Target NameOTC
    Gene ID5009,18416,25611,698428,480878,101087817,280887,100050268
    Gene Symbol and SynonymsOCTD,OTC,OTC1,OTCase,OTCD,Sf,spf
    Uniprot AccessionP00480,P00481,Q9N1U7
    Uniprot Entry NameOTC_HUMAN,OTC_RAT,OTC_BOVIN
    Protein Sub-locationIntrocelluar Protein
    CategoryTherapeutics Target
    DiseaseN/A
    Gene EnsemblENSG00000036473
    Target ClassificationN/A

    The target: OTC, gene name: OTC, also named as OCTD. This nuclear gene encodes a mitochondrial matrix enzyme. The encoded protein is involved in the urea cycle which functions to detoxify ammonia into urea for excretion. Mutations in this enzyme lead to ornithine transcarbamylase deficiency, which causes hyperammonemia. [provided by RefSeq, May 2022].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.