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Anti-ANAG/ NAGLU/ CMT2V functional antibody
Anti-ANAG/ NAGLU/ CMT2V functional antibody for cell culture, ELISA & in-vivo assay
Go to NAGLU/NAGLU products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T53103-Ab-1/ GM-Tg-hg-T53103-Ab-2 | Anti-Human NAGLU monoclonal antibody | Human |
| GM-Tg-rg-T53103-Ab-1/ GM-Tg-rg-T53103-Ab-2 | Anti-Rat NAGLU monoclonal antibody | Rat |
| GM-Tg-mg-T53103-Ab-1/ GM-Tg-mg-T53103-Ab-2 | Anti-Mouse NAGLU monoclonal antibody | Mouse |
| GM-Tg-cynog-T53103-Ab-1/ GM-Tg-cynog-T53103-Ab-2 | Anti-Cynomolgus/ Rhesus macaque NAGLU monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T53103-Ab-1/ GM-Tg-felg-T53103-Ab-2 | Anti-Feline NAGLU monoclonal antibody | Feline |
| GM-Tg-cang-T53103-Ab-1/ GM-Tg-cang-T53103-Ab-2 | Anti-Canine NAGLU monoclonal antibody | Canine |
| GM-Tg-bovg-T53103-Ab-1/ GM-Tg-bovg-T53103-Ab-2 | Anti-Bovine NAGLU monoclonal antibody | Bovine |
| GM-Tg-equg-T53103-Ab-1/ GM-Tg-equg-T53103-Ab-2 | Anti-Equine NAGLU monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T53103-Ab-1/ GM-Tg-hg-T53103-Ab-2; GM-Tg-rg-T53103-Ab-1/ GM-Tg-rg-T53103-Ab-2; GM-Tg-mg-T53103-Ab-1/ GM-Tg-mg-T53103-Ab-2; GM-Tg-cynog-T53103-Ab-1/ GM-Tg-cynog-T53103-Ab-2; GM-Tg-felg-T53103-Ab-1/ GM-Tg-felg-T53103-Ab-2; GM-Tg-cang-T53103-Ab-1/ GM-Tg-cang-T53103-Ab-2; GM-Tg-bovg-T53103-Ab-1/ GM-Tg-bovg-T53103-Ab-2; GM-Tg-equg-T53103-Ab-1/ GM-Tg-equg-T53103-Ab-2 |
| Products Name | Anti-NAGLU monoclonal antibody |
| Format | mab |
| Target Name | NAGLU |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-NAGLU benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T53103-Ag-1 | Recombinant multi-species ANAG/ NAGLU/ CMT2V protein |
Target information
| Target ID | GM-T53103 |
| Target Name | NAGLU |
| Gene ID | 4669,27419,360630,707186,490965,101091166,789125,100066052 |
| Gene Symbol and Synonyms | CMT2V,MPS-IIIB,MPS3B,NAG,NAGLU,RGD1564228,UFHSD |
| Uniprot Accession | P54802 |
| Uniprot Entry Name | ANAG_HUMAN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | Therapeutics Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000108784 |
| Target Classification | N/A |
The target: NAGLU, gene name: NAGLU, also named as CMT2V, MPS-IIIB, MPS3B, NAG, UFHSD. This gene encodes an enzyme that degrades heparan sulfate by hydrolysis of terminal N-acetyl-D-glucosamine residues in N-acetyl-alpha-D-glucosaminides. Defects in this gene are the cause of mucopolysaccharidosis type IIIB (MPS-IIIB), also known as Sanfilippo syndrome B. This disease is characterized by the lysosomal accumulation and urinary excretion of heparan sulfate. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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