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Anti-ANGL3/ ANGPTL3/ ANG-5 functional antibody
Anti-ANGL3/ ANGPTL3/ ANG-5 functional antibody for cell culture, ELISA & in-vivo assay
Go to ANGPTL3/ANGPTL3 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T53139-Ab-1/ GM-Tg-hg-T53139-Ab-2 | Anti-Human ANGPTL3 monoclonal antibody | Human |
| GM-Tg-rg-T53139-Ab-1/ GM-Tg-rg-T53139-Ab-2 | Anti-Rat ANGPTL3 monoclonal antibody | Rat |
| GM-Tg-mg-T53139-Ab-1/ GM-Tg-mg-T53139-Ab-2 | Anti-Mouse ANGPTL3 monoclonal antibody | Mouse |
| GM-Tg-cynog-T53139-Ab-1/ GM-Tg-cynog-T53139-Ab-2 | Anti-Cynomolgus/ Rhesus macaque ANGPTL3 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T53139-Ab-1/ GM-Tg-felg-T53139-Ab-2 | Anti-Feline ANGPTL3 monoclonal antibody | Feline |
| GM-Tg-cang-T53139-Ab-1/ GM-Tg-cang-T53139-Ab-2 | Anti-Canine ANGPTL3 monoclonal antibody | Canine |
| GM-Tg-bovg-T53139-Ab-1/ GM-Tg-bovg-T53139-Ab-2 | Anti-Bovine ANGPTL3 monoclonal antibody | Bovine |
| GM-Tg-equg-T53139-Ab-1/ GM-Tg-equg-T53139-Ab-2 | Anti-Equine ANGPTL3 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T53139-Ab-1/ GM-Tg-hg-T53139-Ab-2; GM-Tg-rg-T53139-Ab-1/ GM-Tg-rg-T53139-Ab-2; GM-Tg-mg-T53139-Ab-1/ GM-Tg-mg-T53139-Ab-2; GM-Tg-cynog-T53139-Ab-1/ GM-Tg-cynog-T53139-Ab-2; GM-Tg-felg-T53139-Ab-1/ GM-Tg-felg-T53139-Ab-2; GM-Tg-cang-T53139-Ab-1/ GM-Tg-cang-T53139-Ab-2; GM-Tg-bovg-T53139-Ab-1/ GM-Tg-bovg-T53139-Ab-2; GM-Tg-equg-T53139-Ab-1/ GM-Tg-equg-T53139-Ab-2 |
| Products Name | Anti-ANGPTL3 monoclonal antibody |
| Format | mab |
| Target Name | ANGPTL3 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-ANGPTL3 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Biosimilar | GMP-Bios-ab-201 | Pre-Made Evinacumab biosimilar, Whole mAb, Anti-ANGPTL3 Antibody: Anti-ANG-5/ANGPT5/ANL3/FHBL2 therapeutic antibody |
| Target Antigen | GM-Tg-g-T53139-Ag-1 | Recombinant multi-species ANGL3/ ANGPTL3/ ANG-5 protein |
| ORF Viral Vector | vGMLP000724 | human ANGPTL3 Lentivirus particle |
| ORF Viral Vector | pGMLP000724 | human ANGPTL3 Lentivirus plasmid |
| ORF Viral Vector | pGMLPm001529 | mouse Angptl3 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm001529 | mouse Angptl3 Lentivirus particle |
Target information
| Target ID | GM-T53139 |
| Target Name | ANGPTL3 |
| Gene ID | 27329,30924,502970,695499,102152922,101081151,782603,100054159 |
| Gene Symbol and Synonyms | ANG-5,ANGPT5,ANGPTL3,ANL3,FHBL2,hypl |
| Uniprot Accession | Q9Y5C1 |
| Uniprot Entry Name | ANGL3_HUMAN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | Therapeutics Target, INN Index |
| Disease | Lung Cancer |
| Gene Ensembl | ENSG00000132855 |
| Target Classification | N/A |
The target: ANGPTL3, gene name: ANGPTL3, also named as ANG-5, ANGPT5, ANL3, FHBL2. This gene encodes a member of a family of secreted proteins that function in angiogenesis. The encoded protein, which is expressed predominantly in the liver, is further processed into an N-terminal coiled-coil domain-containing chain and a C-terminal fibrinogen chain. The N-terminal chain is important for lipid metabolism, while the C-terminal chain may be involved in angiogenesis. Mutations in this gene cause familial hypobetalipoproteinemia type 2. [provided by RefSeq, Aug 2015].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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