Anti-MMP9/ MMP-9/ CLG4B functional antibody

Anti-MMP9/ MMP-9/ CLG4B functional antibody for cell culture, ELISA & in-vivo assay

Target products collectionGo to MMP-9/MMP9 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)


Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T54156-Ab-1/ GM-Tg-hg-T54156-Ab-2Anti-Human MMP-9/MMP9 monoclonal antibodyHuman
GM-Tg-rg-T54156-Ab-1/ GM-Tg-rg-T54156-Ab-2Anti-Rat MMP-9/MMP9 monoclonal antibodyRat
GM-Tg-mg-T54156-Ab-1/ GM-Tg-mg-T54156-Ab-2Anti-Mouse MMP-9/MMP9 monoclonal antibodyMouse
GM-Tg-cynog-T54156-Ab-1/ GM-Tg-cynog-T54156-Ab-2Anti-Cynomolgus/ Rhesus macaque MMP-9/MMP9 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T54156-Ab-1/ GM-Tg-felg-T54156-Ab-2Anti-Feline MMP-9/MMP9 monoclonal antibodyFeline
GM-Tg-cang-T54156-Ab-1/ GM-Tg-cang-T54156-Ab-2Anti-Canine MMP-9/MMP9 monoclonal antibodyCanine
GM-Tg-bovg-T54156-Ab-1/ GM-Tg-bovg-T54156-Ab-2Anti-Bovine MMP-9/MMP9 monoclonal antibodyBovine
GM-Tg-equg-T54156-Ab-1/ GM-Tg-equg-T54156-Ab-2Anti-Equine MMP-9/MMP9 monoclonal antibodyEquine

Size: 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T54156-Ab-1/ GM-Tg-hg-T54156-Ab-2; GM-Tg-rg-T54156-Ab-1/ GM-Tg-rg-T54156-Ab-2;
GM-Tg-mg-T54156-Ab-1/ GM-Tg-mg-T54156-Ab-2; GM-Tg-cynog-T54156-Ab-1/ GM-Tg-cynog-T54156-Ab-2;
GM-Tg-felg-T54156-Ab-1/ GM-Tg-felg-T54156-Ab-2; GM-Tg-cang-T54156-Ab-1/ GM-Tg-cang-T54156-Ab-2;
GM-Tg-bovg-T54156-Ab-1/ GM-Tg-bovg-T54156-Ab-2; GM-Tg-equg-T54156-Ab-1/ GM-Tg-equg-T54156-Ab-2
Products NameAnti-MMP-9/MMP9 monoclonal antibody
Formatmab
Target NameMMP-9
Protein Sub-locationSecreted Protein/Potential Cytokines
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)
IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-MMP-9 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


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    Associated products


    CategoryCat No.Products Name
    BiosimilarGMP-Bios-ab-024Pre-Made Andecaliximab biosimilar, Whole mAb, Anti-MMP9/MMP-9 Antibody: Anti-CLG4B/GELB/MANDP2 therapeutic antibody
    Target AntigenGM-Tg-g-T54156-Ag-1Recombinant multi-species MMP9/ MMP-9/ CLG4B protein
    ORF Viral VectorpGMAP000473Human MMP9 Adenovirus plasmid
    ORF Viral VectorvGMAP000473Human MMP9 Adenovirus particle


    Target information

    Target IDGM-T54156
    Target NameMMP-9
    Gene ID4318,17395,81687,708084,403885,101084185,282871,100056599
    Gene Symbol and SynonymsB/MMP9,CLG4B,Gel B,GELB,MANDP2,MMP-9,MMP9,pro-MMP-9
    Uniprot AccessionP14780,P50282,O18733,P52176
    Uniprot Entry NameMMP9_HUMAN,MMP9_RAT,MMP9_CANLF,MMP9_BOVIN
    Protein Sub-locationSecreted Protein/Potential Cytokines
    CategoryTherapeutics Target, INN Index
    DiseaseBreast Cancer, Malignant neoplasm of bladder, Renal cell carcinoma, Neoplasm, Hemangioma, Malignant neoplasms of female genital organs, Alport syndrome, Calculus of kidney, Chronic Kidney Disease, Chronic tubulo-interstitial nephritis, Congenital occlusion of ureteropelvic junction
    Gene EnsemblENSG00000100985
    Target ClassificationN/A

    The target: MMP-9, gene name: MMP9, also named as CLG4B, GELB, MANDP2, MMP-9. Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades type IV and V collagens. Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow, and murine studies suggest a role in tumor-associated tissue remodeling. [provided by RefSeq, Jul 2008].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.