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Anti-IFNL3/ IFN-lambda-3/ IFN-lambda-4 functional antibody
Anti-IFNL3/ IFN-lambda-3/ IFN-lambda-4 functional antibody for cell culture, ELISA & in-vivo assay
Go to IFNL3/IFNL3 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T55242-Ab-1/ GM-Tg-hg-T55242-Ab-2 | Anti-Human IFNL3 monoclonal antibody | Human |
| GM-Tg-rg-T55242-Ab-1/ GM-Tg-rg-T55242-Ab-2 | Anti-Rat IFNL3 monoclonal antibody | Rat |
| GM-Tg-mg-T55242-Ab-1/ GM-Tg-mg-T55242-Ab-2 | Anti-Mouse IFNL3 monoclonal antibody | Mouse |
| GM-Tg-cynog-T55242-Ab-1/ GM-Tg-cynog-T55242-Ab-2 | Anti-Cynomolgus/ Rhesus macaque IFNL3 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T55242-Ab-1/ GM-Tg-felg-T55242-Ab-2 | Anti-Feline IFNL3 monoclonal antibody | Feline |
| GM-Tg-cang-T55242-Ab-1/ GM-Tg-cang-T55242-Ab-2 | Anti-Canine IFNL3 monoclonal antibody | Canine |
| GM-Tg-bovg-T55242-Ab-1/ GM-Tg-bovg-T55242-Ab-2 | Anti-Bovine IFNL3 monoclonal antibody | Bovine |
| GM-Tg-equg-T55242-Ab-1/ GM-Tg-equg-T55242-Ab-2 | Anti-Equine IFNL3 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T55242-Ab-1/ GM-Tg-hg-T55242-Ab-2; GM-Tg-rg-T55242-Ab-1/ GM-Tg-rg-T55242-Ab-2; GM-Tg-mg-T55242-Ab-1/ GM-Tg-mg-T55242-Ab-2; GM-Tg-cynog-T55242-Ab-1/ GM-Tg-cynog-T55242-Ab-2; GM-Tg-felg-T55242-Ab-1/ GM-Tg-felg-T55242-Ab-2; GM-Tg-cang-T55242-Ab-1/ GM-Tg-cang-T55242-Ab-2; GM-Tg-bovg-T55242-Ab-1/ GM-Tg-bovg-T55242-Ab-2; GM-Tg-equg-T55242-Ab-1/ GM-Tg-equg-T55242-Ab-2 |
| Products Name | Anti-IFNL3 monoclonal antibody |
| Format | mab |
| Target Name | IFNL3 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-IFNL3 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T55242-Ag-1 | Recombinant multi-species IFNL3/ IFN-lambda-3/ IFN-lambda-4 protein |
| Cytokine | GM-Tg-g-T55242-Ag-1 | interferon, lambda 3 (IFNL3) protein |
| ORF Viral Vector | pGMLP002948 | human IFNL3 Lentivirus plasmid |
| ORF Viral Vector | vGMLP002948 | human IFNL3 Lentivirus particle |
| ORF Viral Vector | pGMLPm002230 | mouse Ifnl3 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm002230 | mouse Ifnl3 Lentivirus particle |
Target information
| Target ID | GM-T55242 |
| Target Name | IFNL3 |
| Gene ID | 282617,695997 |
| Gene Symbol and Synonyms | IFN-lambda-3,IFN-lambda-4,IFNL3,IL-28B,IL-28C,IL28A,IL28B,IL28C |
| Uniprot Accession | Q8IZI9 |
| Uniprot Entry Name | IFNL3_HUMAN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | Therapeutics Target, Cytokine Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000197110 |
| Target Classification | N/A |
The target: IFNL3, gene name: IFNL3, also named as IFN-lambda-3, IFN-lambda-4, IL-28B, IL-28C, IL28B, IL28C. This gene encodes a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin 28A (IL28A), and interleukin 29 (IL29) are three closely related cytokine genes that form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha (IL28RA). [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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