Anti-TNFL4/ OX40/ TNFSF4 monoclonal antibody

Anti-TNFL4/ OX40/ TNFSF4 antibody for FACS & in-vivo assay

Target products collectionGo to OX40/TNFSF4 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T55860-Ab-1/ GM-Tg-hg-T55860-Ab-2Anti-Human OX40/TNFSF4 monoclonal antibodyHuman
GM-Tg-rg-T55860-Ab-1/ GM-Tg-rg-T55860-Ab-2Anti-Rat OX40/TNFSF4 monoclonal antibodyRat
GM-Tg-mg-T55860-Ab-1/ GM-Tg-mg-T55860-Ab-2Anti-Mouse OX40/TNFSF4 monoclonal antibodyMouse
GM-Tg-cynog-T55860-Ab-1/ GM-Tg-cynog-T55860-Ab-2Anti-Cynomolgus/ Rhesus macaque OX40/TNFSF4 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T55860-Ab-1/ GM-Tg-felg-T55860-Ab-2Anti-Feline OX40/TNFSF4 monoclonal antibodyFeline
GM-Tg-cang-T55860-Ab-1/ GM-Tg-cang-T55860-Ab-2Anti-Canine OX40/TNFSF4 monoclonal antibodyCanine
GM-Tg-bovg-T55860-Ab-1/ GM-Tg-bovg-T55860-Ab-2Anti-Bovine OX40/TNFSF4 monoclonal antibodyBovine
GM-Tg-equg-T55860-Ab-1/ GM-Tg-equg-T55860-Ab-2Anti-Equine OX40/TNFSF4 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T55860-Ab-1/ GM-Tg-hg-T55860-Ab-2; GM-Tg-rg-T55860-Ab-1/ GM-Tg-rg-T55860-Ab-2;
GM-Tg-mg-T55860-Ab-1/ GM-Tg-mg-T55860-Ab-2; GM-Tg-cynog-T55860-Ab-1/ GM-Tg-cynog-T55860-Ab-2;
GM-Tg-felg-T55860-Ab-1/ GM-Tg-felg-T55860-Ab-2; GM-Tg-cang-T55860-Ab-1/ GM-Tg-cang-T55860-Ab-2;
GM-Tg-bovg-T55860-Ab-1/ GM-Tg-bovg-T55860-Ab-2; GM-Tg-equg-T55860-Ab-1/ GM-Tg-equg-T55860-Ab-2
Products NameAnti-OX40/TNFSF4 monoclonal antibody
Formatmab
Target NameOX40
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-OX40 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


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    Associated products


    CategoryCat No.Products Name
    BiosimilarGMP-Bios-ab-553Pre-Made Tavolimab biosimilar, Whole mAb, Anti-TNFSF4/OX40 Antibody: Anti-CD134L/CD252/GP34/OX-40L/OX4OL/TNLG2B/TXGP1 therapeutic antibody
    BiosimilarGMP-Bios-ab-417Pre-Made Oxelumab biosimilar, Whole mAb, Anti-TNFSF4/OX40 Antibody: Anti-CD134L/CD252/GP34/OX-40L/OX4OL/TNLG2B/TXGP1 therapeutic antibody
    BiosimilarGMP-Bios-ab-554Pre-Made Tavolixizumab biosimilar, Whole mAb, Anti-TNFSF4/OX40 Antibody: Anti-CD134L/CD252/GP34/OX-40L/OX4OL/TNLG2B/TXGP1 therapeutic antibody
    BiosimilarGMP-Bios-ab-022Pre-Made Amlitelimab biosimilar, Whole mAb, Anti-TNFSF4/OX40 Antibody: Anti-CD134L/CD252/GP34/OX-40L/OX4OL/TNLG2B/TXGP1 therapeutic antibody
    Target AntigenProducts DevelopingMulti-species TNFL4/ OX40/ TNFSF4 VLP (virus-like particle) (Products Developing)
    CytokineGM-Tg-g-T55860-Ag-1tumor necrosis factor (ligand) superfamily, member 4 (TNFSF4) protein
    ORF Viral VectorvGMLP001853human TNFSF4 Lentivirus particle
    ORF Viral VectorpGMLP001853human TNFSF4 Lentivirus plasmid
    ORF Viral VectorpGMLPm000309mouse Tnfsf4 Lentivirus plasmid
    ORF Viral VectorvGMLPm000309mouse Tnfsf4 Lentivirus particle


    Target information

    Target IDGM-T55860
    Target NameOX40
    Gene ID7292,22164,89814,706255,100855878,790947,539800,100060605
    Gene Symbol and SynonymsAth-1,Ath1,CD134L,CD252,GP34,OX-40L,Ox40l,OX4OL,TNFSF4,TNLG2B,TXGP1,Txgp1l
    Uniprot AccessionP23510,Q9Z2P3
    Uniprot Entry NameTNFL4_HUMAN,TNFL4_RAT
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target, Immuno-oncology Target, INN Index, Cytokine Target
    DiseaseN/A
    Gene EnsemblENSG00000117586
    Target ClassificationCheckpoint-Immuno Oncology

    The target: OX40, gene name: TNFSF4, also named as CD134L, CD252, GP34, OX-40L, OX4OL, TNLG2B, TXGP1. This gene encodes a cytokine of the tumor necrosis factor (TNF) ligand family. The encoded protein functions in T cell antigen-presenting cell (APC) interactions and mediates adhesion of activated T cells to endothelial cells. Polymorphisms in this gene have been associated with Sjogren's syndrome and systemic lupus erythematosus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.