Anti-IL11/ AGIF/ IL-11 functional antibody

Anti-IL11/ AGIF/ IL-11 functional antibody for cell culture, ELISA & in-vivo assay

Target products collectionGo to IL11/IL11 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)


Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T56308-Ab-1/ GM-Tg-hg-T56308-Ab-2Anti-Human IL11 monoclonal antibodyHuman
GM-Tg-rg-T56308-Ab-1/ GM-Tg-rg-T56308-Ab-2Anti-Rat IL11 monoclonal antibodyRat
GM-Tg-mg-T56308-Ab-1/ GM-Tg-mg-T56308-Ab-2Anti-Mouse IL11 monoclonal antibodyMouse
GM-Tg-cynog-T56308-Ab-1/ GM-Tg-cynog-T56308-Ab-2Anti-Cynomolgus/ Rhesus macaque IL11 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T56308-Ab-1/ GM-Tg-felg-T56308-Ab-2Anti-Feline IL11 monoclonal antibodyFeline
GM-Tg-cang-T56308-Ab-1/ GM-Tg-cang-T56308-Ab-2Anti-Canine IL11 monoclonal antibodyCanine
GM-Tg-bovg-T56308-Ab-1/ GM-Tg-bovg-T56308-Ab-2Anti-Bovine IL11 monoclonal antibodyBovine
GM-Tg-equg-T56308-Ab-1/ GM-Tg-equg-T56308-Ab-2Anti-Equine IL11 monoclonal antibodyEquine

Size: 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T56308-Ab-1/ GM-Tg-hg-T56308-Ab-2; GM-Tg-rg-T56308-Ab-1/ GM-Tg-rg-T56308-Ab-2;
GM-Tg-mg-T56308-Ab-1/ GM-Tg-mg-T56308-Ab-2; GM-Tg-cynog-T56308-Ab-1/ GM-Tg-cynog-T56308-Ab-2;
GM-Tg-felg-T56308-Ab-1/ GM-Tg-felg-T56308-Ab-2; GM-Tg-cang-T56308-Ab-1/ GM-Tg-cang-T56308-Ab-2;
GM-Tg-bovg-T56308-Ab-1/ GM-Tg-bovg-T56308-Ab-2; GM-Tg-equg-T56308-Ab-1/ GM-Tg-equg-T56308-Ab-2
Products NameAnti-IL11 monoclonal antibody
Formatmab
Target NameIL11
Protein Sub-locationSecreted Protein/Potential Cytokines
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)
IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-IL11 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


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    Associated products


    CategoryCat No.Products Name
    Target AntigenGM-Tg-g-T56308-Ag-1Recombinant multi-species IL11/ AGIF/ IL-11 protein
    CytokineGM-Tg-g-T56308-Ag-1interleukin 11 (IL11) protein
    ORF Viral VectorpGMLP003437human IL11 Lentivirus plasmid
    ORF Viral VectorvGMLP003437human IL11 Lentivirus particle
    ORF Viral VectorpGMLPm000111mouse Il11 Lentivirus plasmid
    ORF Viral VectorvGMLPm000111mouse Il11 Lentivirus particle


    Target information

    Target IDGM-T56308
    Target NameIL11
    Gene ID3589,16156,171040,722817,611309,101085086,100337295,100056037
    Gene Symbol and SynonymsAGIF,IL-11,IL11
    Uniprot AccessionP20809,Q99MF5
    Uniprot Entry NameIL11_HUMAN,IL11_RAT
    Protein Sub-locationSecreted Protein/Potential Cytokines
    CategoryTherapeutics Target, Cytokine Target
    DiseaseCancer
    Gene EnsemblENSG00000095752
    Target ClassificationTumor-associated antigen (TAA)

    The target: IL11, gene name: IL11, also named as AGIF, IL-11. The protein encoded by this gene is a member of the gp130 family of cytokines. These cytokines drive the assembly of multisubunit receptor complexes, all of which contain at least one molecule of the transmembrane signaling receptor IL6ST (gp130). This cytokine is shown to stimulate the T-cell-dependent development of immunoglobulin-producing B cells. It is also found to support the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jun 2012].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.