Anti-CXCR2/ CD182/ CDw128b monoclonal antibody

Anti-CXCR2/ CD182/ CDw128b antibody for FACS & in-vivo assay

Target products collectionGo to CXCR2/CXCR2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)


Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T56923-Ab-1/ GM-Tg-hg-T56923-Ab-2Anti-Human CXCR2 monoclonal antibodyHuman
GM-Tg-rg-T56923-Ab-1/ GM-Tg-rg-T56923-Ab-2Anti-Rat CXCR2 monoclonal antibodyRat
GM-Tg-mg-T56923-Ab-1/ GM-Tg-mg-T56923-Ab-2Anti-Mouse CXCR2 monoclonal antibodyMouse
GM-Tg-cynog-T56923-Ab-1/ GM-Tg-cynog-T56923-Ab-2Anti-Cynomolgus/ Rhesus macaque CXCR2 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T56923-Ab-1/ GM-Tg-felg-T56923-Ab-2Anti-Feline CXCR2 monoclonal antibodyFeline
GM-Tg-cang-T56923-Ab-1/ GM-Tg-cang-T56923-Ab-2Anti-Canine CXCR2 monoclonal antibodyCanine
GM-Tg-bovg-T56923-Ab-1/ GM-Tg-bovg-T56923-Ab-2Anti-Bovine CXCR2 monoclonal antibodyBovine
GM-Tg-equg-T56923-Ab-1/ GM-Tg-equg-T56923-Ab-2Anti-Equine CXCR2 monoclonal antibodyEquine

Size: 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T56923-Ab-1/ GM-Tg-hg-T56923-Ab-2; GM-Tg-rg-T56923-Ab-1/ GM-Tg-rg-T56923-Ab-2;
GM-Tg-mg-T56923-Ab-1/ GM-Tg-mg-T56923-Ab-2; GM-Tg-cynog-T56923-Ab-1/ GM-Tg-cynog-T56923-Ab-2;
GM-Tg-felg-T56923-Ab-1/ GM-Tg-felg-T56923-Ab-2; GM-Tg-cang-T56923-Ab-1/ GM-Tg-cang-T56923-Ab-2;
GM-Tg-bovg-T56923-Ab-1/ GM-Tg-bovg-T56923-Ab-2; GM-Tg-equg-T56923-Ab-1/ GM-Tg-equg-T56923-Ab-2
Products NameAnti-CXCR2 monoclonal antibody
Formatmab
Target NameCXCR2
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)
IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-CXCR2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    Target AntigenProducts DevelopingMulti-species CXCR2/ CD182/ CDw128b VLP (virus-like particle) (Products Developing)
    CytokineGM-Tg-g-T56923-Ag-1chemokine (C-X-C motif) receptor 2 (CXCR2) protein
    ORF Viral VectorvGMLP001481human CXCR2 Lentivirus particle
    ORF Viral VectorpGMLP001481human CXCR2 Lentivirus plasmid
    ORF Viral VectorpGMLV000786house mouse Cxcr2 Lentivirus plasmid
    ORF Viral VectorpGMAAV000045mouse Cxcr2 AAV plasmid
    ORF Viral VectorvGMLV000786house mouse Cxcr2 Lentivirus particle
    ORF Viral VectorvGMAAV000045mouse Cxcr2 AAV particle


    Target information

    Target IDGM-T56923
    Target NameCXCR2
    Gene ID3579,12765,29385,700407,478905,101085396,782719,100055552
    Gene Symbol and SynonymsCD128,CD182,CDw128,CDw128b,CMKAR2,CXC-R2,CXCR-2,CXCR2,Gpcr16,IL-8rb,IL-8Rh,IL8R2,IL8RA,IL8RB,mIL-8RH,WHIMS2
    Uniprot AccessionP25025,P35407,Q28519,O97571
    Uniprot Entry NameCXCR2_HUMAN,CXCR2_MACMU,CXCR2_RAT,CXCR2_CANLF
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target, Immuno-oncology Target, Cytokine Target
    DiseaseCancer
    Gene EnsemblENSG00000180871
    Target ClassificationCheckpoint-Immuno Oncology, GPCR, Tumor-associated antigen (TAA)

    The target: CXCR2, gene name: CXCR2, also named as CD182, CDw128b, CMKAR2, IL8R2, IL8RA, IL8RB. The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. Alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2009].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.