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Anti-E2F1 monoclonal antibody
Pre-made anti-E2F1 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to E2F1/E2F1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T57059-Ab-1/ GM-Tg-hg-T57059-Ab-2 | Anti-Human E2F1 monoclonal antibody | Human |
| GM-Tg-rg-T57059-Ab-1/ GM-Tg-rg-T57059-Ab-2 | Anti-Rat E2F1 monoclonal antibody | Rat |
| GM-Tg-mg-T57059-Ab-1/ GM-Tg-mg-T57059-Ab-2 | Anti-Mouse E2F1 monoclonal antibody | Mouse |
| GM-Tg-cynog-T57059-Ab-1/ GM-Tg-cynog-T57059-Ab-2 | Anti-Cynomolgus/ Rhesus macaque E2F1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T57059-Ab-1/ GM-Tg-felg-T57059-Ab-2 | Anti-Feline E2F1 monoclonal antibody | Feline |
| GM-Tg-cang-T57059-Ab-1/ GM-Tg-cang-T57059-Ab-2 | Anti-Canine E2F1 monoclonal antibody | Canine |
| GM-Tg-bovg-T57059-Ab-1/ GM-Tg-bovg-T57059-Ab-2 | Anti-Bovine E2F1 monoclonal antibody | Bovine |
| GM-Tg-equg-T57059-Ab-1/ GM-Tg-equg-T57059-Ab-2 | Anti-Equine E2F1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T57059-Ab-1/ GM-Tg-hg-T57059-Ab-2; GM-Tg-rg-T57059-Ab-1/ GM-Tg-rg-T57059-Ab-2; GM-Tg-mg-T57059-Ab-1/ GM-Tg-mg-T57059-Ab-2; GM-Tg-cynog-T57059-Ab-1/ GM-Tg-cynog-T57059-Ab-2; GM-Tg-felg-T57059-Ab-1/ GM-Tg-felg-T57059-Ab-2; GM-Tg-cang-T57059-Ab-1/ GM-Tg-cang-T57059-Ab-2; GM-Tg-bovg-T57059-Ab-1/ GM-Tg-bovg-T57059-Ab-2; GM-Tg-equg-T57059-Ab-1/ GM-Tg-equg-T57059-Ab-2 |
| Products Name | Anti-E2F1 monoclonal antibody |
| Format | mab |
| Target Name | E2F1 |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-E2F1 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T57059-Ag-1 | Recombinant multi-species E2F1/ E2F-1/ RBAP1 protein |
| ORF Viral Vector | vGMAD000181 | human E2F1 Adenovirus particle |
| ORF Viral Vector | pGMAD000181 | human E2F1 Adenovirus plasmid |
Target information
| Target ID | GM-T57059 |
| Target Name | E2F1 |
| Gene ID | 1869,13555,399489,714126,485839,101098454,535369,100069192 |
| Gene Symbol and Synonyms | E2F-1,E2F1,mKIAA4009,RBAP1,RBBP3,RBP3,Tg(Wnt1-cre)2Sor |
| Uniprot Accession | Q01094,O09139 |
| Uniprot Entry Name | E2F1_HUMAN,E2F1_RAT |
| Protein Sub-location | Introcelluar Protein |
| Category | Therapeutics Target |
| Disease | Cancer |
| Gene Ensembl | ENSG00000101412 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: E2F1, gene name: E2F1, also named as E2F-1, RBAP1, RBBP3, RBP3. The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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