Anti-ERK2 monoclonal antibody
Pre-made anti-ERK2 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to ERK2/MAPK1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
Product information
Catalog No. | Product Name | Species Reactivity |
---|---|---|
GM-Tg-hg-T58970-Ab-1/ GM-Tg-hg-T58970-Ab-2 | Anti-Human ERK2/MAPK1 monoclonal antibody | Human |
GM-Tg-rg-T58970-Ab-1/ GM-Tg-rg-T58970-Ab-2 | Anti-Rat ERK2/MAPK1 monoclonal antibody | Rat |
GM-Tg-mg-T58970-Ab-1/ GM-Tg-mg-T58970-Ab-2 | Anti-Mouse ERK2/MAPK1 monoclonal antibody | Mouse |
GM-Tg-cynog-T58970-Ab-1/ GM-Tg-cynog-T58970-Ab-2 | Anti-Cynomolgus/ Rhesus macaque ERK2/MAPK1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
GM-Tg-felg-T58970-Ab-1/ GM-Tg-felg-T58970-Ab-2 | Anti-Feline ERK2/MAPK1 monoclonal antibody | Feline |
GM-Tg-cang-T58970-Ab-1/ GM-Tg-cang-T58970-Ab-2 | Anti-Canine ERK2/MAPK1 monoclonal antibody | Canine |
GM-Tg-bovg-T58970-Ab-1/ GM-Tg-bovg-T58970-Ab-2 | Anti-Bovine ERK2/MAPK1 monoclonal antibody | Bovine |
GM-Tg-equg-T58970-Ab-1/ GM-Tg-equg-T58970-Ab-2 | Anti-Equine ERK2/MAPK1 monoclonal antibody | Equine |
Size: 1mg | 10mg | 100mg
Product Description
Catalog No. | GM-Tg-hg-T58970-Ab-1/ GM-Tg-hg-T58970-Ab-2; GM-Tg-rg-T58970-Ab-1/ GM-Tg-rg-T58970-Ab-2; GM-Tg-mg-T58970-Ab-1/ GM-Tg-mg-T58970-Ab-2; GM-Tg-cynog-T58970-Ab-1/ GM-Tg-cynog-T58970-Ab-2; GM-Tg-felg-T58970-Ab-1/ GM-Tg-felg-T58970-Ab-2; GM-Tg-cang-T58970-Ab-1/ GM-Tg-cang-T58970-Ab-2; GM-Tg-bovg-T58970-Ab-1/ GM-Tg-bovg-T58970-Ab-2; GM-Tg-equg-T58970-Ab-1/ GM-Tg-equg-T58970-Ab-2 |
Products Name | Anti-ERK2/MAPK1 monoclonal antibody |
Format | mab |
Target Name | ERK2 |
Protein Sub-location | Introcelluar Protein |
Category of antibody | Therapeutics Target antibody |
Derivation (species) | Mouse |
CH1+2+3 Isotype (Receptor identification) | IgG |
Type of Light Chain (VD-LC) | N/A |
Expression platform | Mammalian Expression |
Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
Tag | Fc |
Products description | Pre-made anti-ERK2 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
Purity | Purity: ≥95% (SDS-PAGE) |
Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
Formulation | Lyophilized from sterile PBS, PH 7.4 |
Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
Category | Cat No. | Products Name |
Target Antigen | GM-Tg-g-T58970-Ag-1 | Recombinant multi-species MK01/ ERK2/ MAPK1 protein |
ORF Viral Vector | vGMLV000835 | human MAPK1 Lentivirus particle |
ORF Viral Vector | pGMLV000835 | human MAPK1 Lentivirus plasmid |
Target information
Target ID | GM-T58970 |
Target Name | ERK2 |
Gene ID | 5594,26413,116590,698569,477575,101087614,327672,100057701 |
Gene Symbol and Synonyms | 9030612K14Rik,ERK,ERK-2,ERK2,ERT1,MAPK1,MAPK2,NS13,p38,p40,p41,p41mapk,p42-MAPK,P42MAPK,PRKM1,PRKM2 |
Uniprot Accession | P28482,P63086,P46196 |
Uniprot Entry Name | MK01_HUMAN,MK01_RAT,MK01_BOVIN |
Protein Sub-location | Introcelluar Protein |
Category | Therapeutics Target |
Disease | Cancer |
Gene Ensembl | ENSG00000100030 |
Target Classification | Kinase, Tumor-associated antigen (TAA) |
The target: ERK2, gene name: MAPK1, also named as ERK, ERK-2, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk, p42-MAPK. This gene encodes a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. One study also suggests that this protein acts as a transcriptional repressor independent of its kinase activity. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene. [provided by RefSeq, Jan 2014].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.