Anti-FZD10/ CD350/ FZ-10 monoclonal antibody

Anti-FZD10/ CD350/ FZ-10 antibody for FACS & in-vivo assay

Target products collectionGo to FZD10/FZD10 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)


Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T59702-Ab-1/ GM-Tg-hg-T59702-Ab-2Anti-Human FZD10 monoclonal antibodyHuman
GM-Tg-rg-T59702-Ab-1/ GM-Tg-rg-T59702-Ab-2Anti-Rat FZD10 monoclonal antibodyRat
GM-Tg-mg-T59702-Ab-1/ GM-Tg-mg-T59702-Ab-2Anti-Mouse FZD10 monoclonal antibodyMouse
GM-Tg-cynog-T59702-Ab-1/ GM-Tg-cynog-T59702-Ab-2Anti-Cynomolgus/ Rhesus macaque FZD10 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T59702-Ab-1/ GM-Tg-felg-T59702-Ab-2Anti-Feline FZD10 monoclonal antibodyFeline
GM-Tg-cang-T59702-Ab-1/ GM-Tg-cang-T59702-Ab-2Anti-Canine FZD10 monoclonal antibodyCanine
GM-Tg-bovg-T59702-Ab-1/ GM-Tg-bovg-T59702-Ab-2Anti-Bovine FZD10 monoclonal antibodyBovine
GM-Tg-equg-T59702-Ab-1/ GM-Tg-equg-T59702-Ab-2Anti-Equine FZD10 monoclonal antibodyEquine

Size: 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T59702-Ab-1/ GM-Tg-hg-T59702-Ab-2; GM-Tg-rg-T59702-Ab-1/ GM-Tg-rg-T59702-Ab-2;
GM-Tg-mg-T59702-Ab-1/ GM-Tg-mg-T59702-Ab-2; GM-Tg-cynog-T59702-Ab-1/ GM-Tg-cynog-T59702-Ab-2;
GM-Tg-felg-T59702-Ab-1/ GM-Tg-felg-T59702-Ab-2; GM-Tg-cang-T59702-Ab-1/ GM-Tg-cang-T59702-Ab-2;
GM-Tg-bovg-T59702-Ab-1/ GM-Tg-bovg-T59702-Ab-2; GM-Tg-equg-T59702-Ab-1/ GM-Tg-equg-T59702-Ab-2
Products NameAnti-FZD10 monoclonal antibody
Formatmab
Target NameFZD10
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)
IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-FZD10 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


    Click to get more Data / Case study about the product.



    Associated products


    CategoryCat No.Products Name
    BiosimilarGMP-Bios-ab-541Pre-Made Tabituximab biosimilar, Whole mAb ADC, Anti-FZD10 Antibody: Anti-CD350/FZ-10/Fz10/FzE7/hFz10 therapeutic antibody
    BiosimilarGMP-Bios-INN-1001Pre-Made Tabituximab Barzuxetan Biosimilar, Whole Mab Adc, Anti-Fzd10 Antibody: Anti-CD350/FZ-10/Fz10/FzE7/hFz10 therapeutic antibody Drug Conjugate
    Target AntigenProducts DevelopingMulti-species FZD10/ CD350/ FZ-10 VLP (virus-like particle) (Products Developing)
    CytokineGM-Tg-g-T59702-Ag-1frizzled class receptor 10 (FZD10) protein


    Target information

    Target IDGM-T59702
    Target NameFZD10
    Gene ID11211,93897,363913,717812,486232,101081169,515323,100062909
    Gene Symbol and SynonymsCD350,FZ-10,Fz10,FZD10,Fzd10-ps1,FzE7,hFz10
    Uniprot AccessionQ9ULW2
    Uniprot Entry NameFZD10_HUMAN
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target, INN Index, Cytokine Target
    DiseaseOvary Cancer
    Gene EnsemblENSG00000111432
    Target ClassificationGPCR

    The target: FZD10, gene name: FZD10, also named as CD350, FZ-10, Fz10, FzE7, hFz10. This gene is a member of the frizzled gene family. Members of this family encode 7-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. Using array analysis, expression of this intronless gene is significantly up-regulated in two cases of primary colon cancer. [provided by RefSeq, Jul 2008].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.