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Anti-GLR/ GCGR/ GGR monoclonal antibody
Anti-GLR/ GCGR/ GGR antibody for FACS & in-vivo assay
Go to GCGR/GCGR products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T60182-Ab-1/ GM-Tg-hg-T60182-Ab-2 | Anti-Human GCGR monoclonal antibody | Human |
| GM-Tg-rg-T60182-Ab-1/ GM-Tg-rg-T60182-Ab-2 | Anti-Rat GCGR monoclonal antibody | Rat |
| GM-Tg-mg-T60182-Ab-1/ GM-Tg-mg-T60182-Ab-2 | Anti-Mouse GCGR monoclonal antibody | Mouse |
| GM-Tg-cynog-T60182-Ab-1/ GM-Tg-cynog-T60182-Ab-2 | Anti-Cynomolgus/ Rhesus macaque GCGR monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T60182-Ab-1/ GM-Tg-felg-T60182-Ab-2 | Anti-Feline GCGR monoclonal antibody | Feline |
| GM-Tg-cang-T60182-Ab-1/ GM-Tg-cang-T60182-Ab-2 | Anti-Canine GCGR monoclonal antibody | Canine |
| GM-Tg-bovg-T60182-Ab-1/ GM-Tg-bovg-T60182-Ab-2 | Anti-Bovine GCGR monoclonal antibody | Bovine |
| GM-Tg-equg-T60182-Ab-1/ GM-Tg-equg-T60182-Ab-2 | Anti-Equine GCGR monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T60182-Ab-1/ GM-Tg-hg-T60182-Ab-2; GM-Tg-rg-T60182-Ab-1/ GM-Tg-rg-T60182-Ab-2; GM-Tg-mg-T60182-Ab-1/ GM-Tg-mg-T60182-Ab-2; GM-Tg-cynog-T60182-Ab-1/ GM-Tg-cynog-T60182-Ab-2; GM-Tg-felg-T60182-Ab-1/ GM-Tg-felg-T60182-Ab-2; GM-Tg-cang-T60182-Ab-1/ GM-Tg-cang-T60182-Ab-2; GM-Tg-bovg-T60182-Ab-1/ GM-Tg-bovg-T60182-Ab-2; GM-Tg-equg-T60182-Ab-1/ GM-Tg-equg-T60182-Ab-2 |
| Products Name | Anti-GCGR monoclonal antibody |
| Format | mab |
| Target Name | GCGR |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-GCGR benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Biosimilar | GMP-Bios-ab-124 | Pre-Made Crotedumab biosimilar, Whole mAb, Anti-GCGR Antibody: Anti-GGR/GL-R/MVAH therapeutic antibody |
| Biosimilar | GMP-Bios-INN-857 | Pre-Made Glucagon Biosimilar, Recombinant Protein targeting GCGR: Recombinant therapeutic protein targeting GGR/GL-R/MVAH |
| Target Antigen | Products Developing | Multi-species GLR/ GCGR/ GGR VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | pGMLP003748 | human GCGR Lentivirus plasmid |
| ORF Viral Vector | vGMLP003748 | human GCGR Lentivirus particle |
| ORF Viral Vector | pGMLPm005312 | mouse Gcgr Lentivirus plasmid |
| ORF Viral Vector | vGMLPm005312 | mouse Gcgr Lentivirus particle |
Target information
| Target ID | GM-T60182 |
| Target Name | GCGR |
| Gene ID | 2642,14527,24953,714542,483368,101099672,515433,100055316 |
| Gene Symbol and Synonyms | GCGR,GGR,GL-R,GR,MVAH |
| Uniprot Accession | P47871,P30082 |
| Uniprot Entry Name | GLR_HUMAN,GLR_RAT |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target, INN Index |
| Disease | N/A |
| Gene Ensembl | ENSG00000215644 |
| Target Classification | GPCR |
The target: GCGR, gene name: GCGR, also named as GGR, GL-R. The protein encoded by this gene is a glucagon receptor that is important in controlling blood glucose levels. Defects in this gene are a cause of non-insulin-dependent diabetes mellitus (NIDDM).[provided by RefSeq, Jan 2010].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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