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Anti-OPRK/ OPRK1/ K-OR-1 monoclonal antibody
Anti-OPRK/ OPRK1/ K-OR-1 antibody for FACS & in-vivo assay
Go to OPRK1/OPRK1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T60693-Ab-1/ GM-Tg-hg-T60693-Ab-2 | Anti-Human OPRK1 monoclonal antibody | Human |
| GM-Tg-rg-T60693-Ab-1/ GM-Tg-rg-T60693-Ab-2 | Anti-Rat OPRK1 monoclonal antibody | Rat |
| GM-Tg-mg-T60693-Ab-1/ GM-Tg-mg-T60693-Ab-2 | Anti-Mouse OPRK1 monoclonal antibody | Mouse |
| GM-Tg-cynog-T60693-Ab-1/ GM-Tg-cynog-T60693-Ab-2 | Anti-Cynomolgus/ Rhesus macaque OPRK1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T60693-Ab-1/ GM-Tg-felg-T60693-Ab-2 | Anti-Feline OPRK1 monoclonal antibody | Feline |
| GM-Tg-cang-T60693-Ab-1/ GM-Tg-cang-T60693-Ab-2 | Anti-Canine OPRK1 monoclonal antibody | Canine |
| GM-Tg-bovg-T60693-Ab-1/ GM-Tg-bovg-T60693-Ab-2 | Anti-Bovine OPRK1 monoclonal antibody | Bovine |
| GM-Tg-equg-T60693-Ab-1/ GM-Tg-equg-T60693-Ab-2 | Anti-Equine OPRK1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T60693-Ab-1/ GM-Tg-hg-T60693-Ab-2; GM-Tg-rg-T60693-Ab-1/ GM-Tg-rg-T60693-Ab-2; GM-Tg-mg-T60693-Ab-1/ GM-Tg-mg-T60693-Ab-2; GM-Tg-cynog-T60693-Ab-1/ GM-Tg-cynog-T60693-Ab-2; GM-Tg-felg-T60693-Ab-1/ GM-Tg-felg-T60693-Ab-2; GM-Tg-cang-T60693-Ab-1/ GM-Tg-cang-T60693-Ab-2; GM-Tg-bovg-T60693-Ab-1/ GM-Tg-bovg-T60693-Ab-2; GM-Tg-equg-T60693-Ab-1/ GM-Tg-equg-T60693-Ab-2 |
| Products Name | Anti-OPRK1 monoclonal antibody |
| Format | mab |
| Target Name | OPRK1 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-OPRK1 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species OPRK/ OPRK1/ K-OR-1 VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | pGMLP001541 | human OPRK1 Lentivirus plasmid |
| ORF Viral Vector | vGMLP001541 | human OPRK1 Lentivirus particle |
| ORF Viral Vector | pGMLPm004851 | mouse Oprk1 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm004851 | mouse Oprk1 Lentivirus particle |
Target information
| Target ID | GM-T60693 |
| Target Name | OPRK1 |
| Gene ID | 4986,18387,29335,710783,486951,101094729,540519,100054492 |
| Gene Symbol and Synonyms | K-OR-1,KOP,KOR,KOR-1,KOR1,MSL-1,OPRK,OPRK1,Oprk2,R21 |
| Uniprot Accession | P41145,P34975,Q2KIP6 |
| Uniprot Entry Name | OPRK_HUMAN,OPRK_RAT,OPRK_BOVIN |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target |
| Disease | N/A |
| Gene Ensembl | ENSG00000082556 |
| Target Classification | GPCR |
The target: OPRK1, gene name: OPRK1, also named as K-OR-1, KOR, KOR-1, OPRK. This gene encodes an opioid receptor, which is a member of the 7 transmembrane-spanning G protein-coupled receptor family. It functions as a receptor for endogenous ligands, as well as a receptor for various synthetic opioids. Ligand binding results in inhibition of adenylate cyclase activity and neurotransmitter release. This opioid receptor plays a role in the perception of pain and mediating the hypolocomotor, analgesic and aversive actions of synthetic opioids. Variations in this gene have also been associated with alcohol dependence and opiate addiction. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2017].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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