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Anti-IBP2/ IGFBP2/ IGF-BP53 functional antibody
Anti-IBP2/ IGFBP2/ IGF-BP53 functional antibody for cell culture, ELISA & in-vivo assay
Go to IGFBP2/IGFBP2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T64268-Ab-1/ GM-Tg-hg-T64268-Ab-2 | Anti-Human IGFBP2 monoclonal antibody | Human |
| GM-Tg-rg-T64268-Ab-1/ GM-Tg-rg-T64268-Ab-2 | Anti-Rat IGFBP2 monoclonal antibody | Rat |
| GM-Tg-mg-T64268-Ab-1/ GM-Tg-mg-T64268-Ab-2 | Anti-Mouse IGFBP2 monoclonal antibody | Mouse |
| GM-Tg-cynog-T64268-Ab-1/ GM-Tg-cynog-T64268-Ab-2 | Anti-Cynomolgus/ Rhesus macaque IGFBP2 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T64268-Ab-1/ GM-Tg-felg-T64268-Ab-2 | Anti-Feline IGFBP2 monoclonal antibody | Feline |
| GM-Tg-cang-T64268-Ab-1/ GM-Tg-cang-T64268-Ab-2 | Anti-Canine IGFBP2 monoclonal antibody | Canine |
| GM-Tg-bovg-T64268-Ab-1/ GM-Tg-bovg-T64268-Ab-2 | Anti-Bovine IGFBP2 monoclonal antibody | Bovine |
| GM-Tg-equg-T64268-Ab-1/ GM-Tg-equg-T64268-Ab-2 | Anti-Equine IGFBP2 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T64268-Ab-1/ GM-Tg-hg-T64268-Ab-2; GM-Tg-rg-T64268-Ab-1/ GM-Tg-rg-T64268-Ab-2; GM-Tg-mg-T64268-Ab-1/ GM-Tg-mg-T64268-Ab-2; GM-Tg-cynog-T64268-Ab-1/ GM-Tg-cynog-T64268-Ab-2; GM-Tg-felg-T64268-Ab-1/ GM-Tg-felg-T64268-Ab-2; GM-Tg-cang-T64268-Ab-1/ GM-Tg-cang-T64268-Ab-2; GM-Tg-bovg-T64268-Ab-1/ GM-Tg-bovg-T64268-Ab-2; GM-Tg-equg-T64268-Ab-1/ GM-Tg-equg-T64268-Ab-2 |
| Products Name | Anti-IGFBP2 monoclonal antibody |
| Format | mab |
| Target Name | IGFBP2 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The biofunction of antibodies are validated with in-vitro assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-IGFBP2 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T64268-Ag-1 | Recombinant multi-species IBP2/ IGFBP2/ IGF-BP53 protein |
| Cytokine | GM-Tg-g-T64268-Ag-1 | insulin-like growth factor binding protein 2, 36kDa (IGFBP2) protein |
| ORF Viral Vector | vGMLP004595 | human IGFBP2 Lentivirus particle |
| ORF Viral Vector | pGMLP004595 | human IGFBP2 Lentivirus plasmid |
| ORF Viral Vector | pGMLPm003848 | mouse Igfbp2 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm003848 | mouse Igfbp2 Lentivirus particle |
Target information
| Target ID | GM-T64268 |
| Target Name | IGFBP2 |
| Gene ID | 3485,16008,25662,696214,488516,101088426,282260,100034061 |
| Gene Symbol and Synonyms | BRL-BP,IBP-2,IBP2,IGF-BP53,Igfbp-2,IGFBP2,ILGFBPA,mIGFBP-2 |
| Uniprot Accession | P18065,P12843,P13384 |
| Uniprot Entry Name | IBP2_HUMAN,IBP2_RAT,IBP2_BOVIN |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Category | Therapeutics Target, Immuno-oncology Target, Cytokine Target |
| Disease | Ovary Cancer, Dent disease |
| Gene Ensembl | ENSG00000115457 |
| Target Classification | Checkpoint-Immuno Oncology |
The target: IGFBP2, gene name: IGFBP2, also named as IBP2, IGF-BP53. The protein encoded by this gene is one of six similar proteins that bind insulin-like growth factors I and II (IGF-I and IGF-II). The encoded protein can be secreted into the bloodstream, where it binds IGF-I and IGF-II with high affinity, or it can remain intracellular, interacting with many different ligands. High expression levels of this protein promote the growth of several types of tumors and may be predictive of the chances of recovery of the patient. Several transcript variants, one encoding a secreted isoform and the others encoding nonsecreted isoforms, have been found for this gene. [provided by RefSeq, Sep 2015].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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