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Anti-SGK1 monoclonal antibody
Pre-made anti-SGK1 monoclonal antibody(mab)-benchmark antibody for ELISA, affinity binding assay, drug discovery and mechanism of action (MOA) research
Go to SGK1/SGK1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T64682-Ab-1/ GM-Tg-hg-T64682-Ab-2 | Anti-Human SGK1 monoclonal antibody | Human |
| GM-Tg-rg-T64682-Ab-1/ GM-Tg-rg-T64682-Ab-2 | Anti-Rat SGK1 monoclonal antibody | Rat |
| GM-Tg-mg-T64682-Ab-1/ GM-Tg-mg-T64682-Ab-2 | Anti-Mouse SGK1 monoclonal antibody | Mouse |
| GM-Tg-cynog-T64682-Ab-1/ GM-Tg-cynog-T64682-Ab-2 | Anti-Cynomolgus/ Rhesus macaque SGK1 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T64682-Ab-1/ GM-Tg-felg-T64682-Ab-2 | Anti-Feline SGK1 monoclonal antibody | Feline |
| GM-Tg-cang-T64682-Ab-1/ GM-Tg-cang-T64682-Ab-2 | Anti-Canine SGK1 monoclonal antibody | Canine |
| GM-Tg-bovg-T64682-Ab-1/ GM-Tg-bovg-T64682-Ab-2 | Anti-Bovine SGK1 monoclonal antibody | Bovine |
| GM-Tg-equg-T64682-Ab-1/ GM-Tg-equg-T64682-Ab-2 | Anti-Equine SGK1 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T64682-Ab-1/ GM-Tg-hg-T64682-Ab-2; GM-Tg-rg-T64682-Ab-1/ GM-Tg-rg-T64682-Ab-2; GM-Tg-mg-T64682-Ab-1/ GM-Tg-mg-T64682-Ab-2; GM-Tg-cynog-T64682-Ab-1/ GM-Tg-cynog-T64682-Ab-2; GM-Tg-felg-T64682-Ab-1/ GM-Tg-felg-T64682-Ab-2; GM-Tg-cang-T64682-Ab-1/ GM-Tg-cang-T64682-Ab-2; GM-Tg-bovg-T64682-Ab-1/ GM-Tg-bovg-T64682-Ab-2; GM-Tg-equg-T64682-Ab-1/ GM-Tg-equg-T64682-Ab-2 |
| Products Name | Anti-SGK1 monoclonal antibody |
| Format | mab |
| Target Name | SGK1 |
| Protein Sub-location | Introcelluar Protein |
| Category of antibody | Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by ELISA with recombinant soluble protein antigen. The potency in neutralizing, inhibiting or blocking of the target protein is not detected. |
| Tag | Fc |
| Products description | Pre-made anti-SGK1 monoclonal antibody(mab) is expressed by mammalian cell line as a benchmark antibody for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | GM-Tg-g-T64682-Ag-1 | Recombinant multi-species SGK1/ SGK protein |
| ORF Viral Vector | pGMLP002697 | human SGK1 Lentivirus plasmid |
| ORF Viral Vector | vGMLP002697 | human SGK1 Lentivirus particle |
| ORF Viral Vector | pGMLPm005360 | mouse Sgk1 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm005360 | mouse Sgk1 Lentivirus particle |
Target information
| Target ID | GM-T64682 |
| Target Name | SGK1 |
| Gene ID | 6446,20393,29517,713082,403647,101098954,515854,100073151 |
| Gene Symbol and Synonyms | SGK,SGK1 |
| Uniprot Accession | O00141,Q06226,A7MB74 |
| Uniprot Entry Name | SGK1_HUMAN,SGK1_RAT,SGK1_BOVIN |
| Protein Sub-location | Introcelluar Protein |
| Category | Therapeutics Target |
| Disease | Cancer |
| Gene Ensembl | ENSG00000118515 |
| Target Classification | Kinase, Tumor-associated antigen (TAA) |
The target: SGK1, gene name: SGK1, also named as SGK. This gene encodes a serine/threonine protein kinase that plays an important role in cellular stress response. This kinase activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. High levels of expression of this gene may contribute to conditions such as hypertension and diabetic nephropathy. Several alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jan 2009].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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