Anti-EGFR/ EGFR vIII/ ERBB antibody for FACS & in-vivo assay| GMab

Pre-made anti-EGFR vIII benchmark inhibitory monoclonal antibody(mab, blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic). The anti-EGFR vIII mab is expressed and produced by mammalian cell line as a benchmark reference therapeutic antibody for biological drug discovery items including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.

The target: EGFR vIII, gene name: EGFR, also named as ERBB, ERBB1, HER1, NISBD2, PIG61, mENA. The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor, thus inducing receptor dimerization and tyrosine autophosphorylation leading to cell proliferation. Mutations in this gene are associated with lung cancer. EGFR is a component of the cytokine storm which contributes to a severe form of Coronavirus Disease 2019 (COVID-19) resulting from infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). [provided by RefSeq, Jul 2020].

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Catalog No.	List Price (In USD)	Discount Price (In USD)	Qty (Quantity)	Sum (In USD)
GM-Tg-hg-T64969-Ab-1-1mg	5150	3090
GM-Tg-hg-T64969-Ab-1-10mg	Inquiry	Inquiry
GM-Tg-hg-T64969-Ab-1-100mg	Inquiry	Inquiry
GM-Tg-hg-T64969-Ab-2-1mg	5150	3090
GM-Tg-hg-T64969-Ab-2-10mg	Inquiry	Inquiry
GM-Tg-hg-T64969-Ab-2-100mg	Inquiry	Inquiry
GM-Tg-hg-T64969-Ab-xmg	Inquiry	Inquiry
			Shipping Cost:	760.00
			Total:

Description

Catalog No.	GM-Tg-hg-T64969-Ab-1, GM-Tg-hg-T64969-Ab-2
Products Name	Anti-EGFR vIII/EGFR monoclonal antibody
Format	mab
Target Name	EGFR vIII
Gene ID	EGFR
Gene Name	EGFR
Gene Alias	ERBB, ERBB1, HER1, NISBD2, PIG61, mENA
Protein Sub-location	Transmembrane Protein
Category of antibody	FACS/Biofunctional Antibody
Derivation (species)	Mouse
Species Reactivity	Human(H)
CH1+2+3 Isotype (Receptor identification)	IgG
Type of Light Chain (VD-LC)	N/A
Expression platform	Mammalian Expression
Bioactivity validation	Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
Tag	Fc
Products description	Pre-made anti-EGFR vIII benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity	Purity: ≥95% (SDS-PAGE)
Application	Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation	Lyophilized from sterile PBS, PH 7.4
Storage	Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.