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Anti-MMP14/ MMP-14/ MMP-X1 monoclonal antibody
Anti-MMP14/ MMP-14/ MMP-X1 antibody for FACS & in-vivo assay
Go to MMP-14/MMP14 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T65019-Ab-1/ GM-Tg-hg-T65019-Ab-2 | Anti-Human MMP-14/MMP14 monoclonal antibody | Human |
| GM-Tg-rg-T65019-Ab-1/ GM-Tg-rg-T65019-Ab-2 | Anti-Rat MMP-14/MMP14 monoclonal antibody | Rat |
| GM-Tg-mg-T65019-Ab-1/ GM-Tg-mg-T65019-Ab-2 | Anti-Mouse MMP-14/MMP14 monoclonal antibody | Mouse |
| GM-Tg-cynog-T65019-Ab-1/ GM-Tg-cynog-T65019-Ab-2 | Anti-Cynomolgus/ Rhesus macaque MMP-14/MMP14 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T65019-Ab-1/ GM-Tg-felg-T65019-Ab-2 | Anti-Feline MMP-14/MMP14 monoclonal antibody | Feline |
| GM-Tg-cang-T65019-Ab-1/ GM-Tg-cang-T65019-Ab-2 | Anti-Canine MMP-14/MMP14 monoclonal antibody | Canine |
| GM-Tg-bovg-T65019-Ab-1/ GM-Tg-bovg-T65019-Ab-2 | Anti-Bovine MMP-14/MMP14 monoclonal antibody | Bovine |
| GM-Tg-equg-T65019-Ab-1/ GM-Tg-equg-T65019-Ab-2 | Anti-Equine MMP-14/MMP14 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T65019-Ab-1/ GM-Tg-hg-T65019-Ab-2; GM-Tg-rg-T65019-Ab-1/ GM-Tg-rg-T65019-Ab-2; GM-Tg-mg-T65019-Ab-1/ GM-Tg-mg-T65019-Ab-2; GM-Tg-cynog-T65019-Ab-1/ GM-Tg-cynog-T65019-Ab-2; GM-Tg-felg-T65019-Ab-1/ GM-Tg-felg-T65019-Ab-2; GM-Tg-cang-T65019-Ab-1/ GM-Tg-cang-T65019-Ab-2; GM-Tg-bovg-T65019-Ab-1/ GM-Tg-bovg-T65019-Ab-2; GM-Tg-equg-T65019-Ab-1/ GM-Tg-equg-T65019-Ab-2 |
| Products Name | Anti-MMP-14/MMP14 monoclonal antibody |
| Format | mab |
| Target Name | MMP-14 |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-MMP-14 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species MMP14/ MMP-14/ MMP-X1 VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | pGMLP002781 | human MMP14 Lentivirus plasmid |
| ORF Viral Vector | vGMLP002781 | human MMP14 Lentivirus particle |
Target information
| Target ID | GM-T65019 |
| Target Name | MMP-14 |
| Gene ID | 4323,17387,81707,712429,403823,101089776,281915,100034170 |
| Gene Symbol and Synonyms | MMP-14,MMP-X1,MMP14,MT-MMP,MT-MMP 1,MT-MMP-1,MT1-MMP,MT1MMP,M™MP1,sabe,WNCHRS |
| Uniprot Accession | P50281,Q10739,Q9GLE4 |
| Uniprot Entry Name | MMP14_HUMAN,MMP14_RAT,MMP14_BOVIN |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target |
| Disease | Cancer |
| Gene Ensembl | ENSG00000157227 |
| Target Classification | Tumor-associated antigen (TAA) |
The target: MMP-14, gene name: MMP14, also named as MMP-14, MMP-X1, MT-MMP, MT-MMP 1, MT1-MMP, MT1MMP, M™MP1, WNCHRS. Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 protein, and this activity may be involved in tumor invasion. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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