Anti-5NTD/ CD73/ NT5E monoclonal antibody

Anti-5NTD/ CD73/ NT5E antibody for FACS & in-vivo assay

Target products collectionGo to CD73/NT5E products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)


Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T65116-Ab-1/ GM-Tg-hg-T65116-Ab-2Anti-Human CD73/NT5E monoclonal antibodyHuman
GM-Tg-rg-T65116-Ab-1/ GM-Tg-rg-T65116-Ab-2Anti-Rat CD73/NT5E monoclonal antibodyRat
GM-Tg-mg-T65116-Ab-1/ GM-Tg-mg-T65116-Ab-2Anti-Mouse CD73/NT5E monoclonal antibodyMouse
GM-Tg-cynog-T65116-Ab-1/ GM-Tg-cynog-T65116-Ab-2Anti-Cynomolgus/ Rhesus macaque CD73/NT5E monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T65116-Ab-1/ GM-Tg-felg-T65116-Ab-2Anti-Feline CD73/NT5E monoclonal antibodyFeline
GM-Tg-cang-T65116-Ab-1/ GM-Tg-cang-T65116-Ab-2Anti-Canine CD73/NT5E monoclonal antibodyCanine
GM-Tg-bovg-T65116-Ab-1/ GM-Tg-bovg-T65116-Ab-2Anti-Bovine CD73/NT5E monoclonal antibodyBovine
GM-Tg-equg-T65116-Ab-1/ GM-Tg-equg-T65116-Ab-2Anti-Equine CD73/NT5E monoclonal antibodyEquine

Size: 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T65116-Ab-1/ GM-Tg-hg-T65116-Ab-2; GM-Tg-rg-T65116-Ab-1/ GM-Tg-rg-T65116-Ab-2;
GM-Tg-mg-T65116-Ab-1/ GM-Tg-mg-T65116-Ab-2; GM-Tg-cynog-T65116-Ab-1/ GM-Tg-cynog-T65116-Ab-2;
GM-Tg-felg-T65116-Ab-1/ GM-Tg-felg-T65116-Ab-2; GM-Tg-cang-T65116-Ab-1/ GM-Tg-cang-T65116-Ab-2;
GM-Tg-bovg-T65116-Ab-1/ GM-Tg-bovg-T65116-Ab-2; GM-Tg-equg-T65116-Ab-1/ GM-Tg-equg-T65116-Ab-2
Products NameAnti-CD73/NT5E monoclonal antibody
Formatmab
Target NameCD73
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)
IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-CD73 benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


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    Associated products


    CategoryCat No.Products Name
    BiosimilarGMP-Bios-ab-394Pre-Made Oleclumab biosimilar, Whole mAb, Anti-NT5E/CD73 Antibody: Anti-NT/eN/NT5/NTE/eNT/E5NT/CALJA therapeutic antibody
    BiosimilarGMP-Bios-ab-599Pre-Made Uliledlimab biosimilar, Whole mAb, Anti-NT5E/CD73 Antibody: Anti-NT/eN/NT5/NTE/eNT/E5NT/CALJA therapeutic antibody
    BiosimilarGMP-Bios-ab-660Pre-Made Dresbuxelimab biosimilar, Whole mAb, Anti-NT5E/CD73 Antibody: Anti-NT/eN/NT5/NTE/eNT/E5NT/CALJA therapeutic antibody
    BiosimilarGMP-Bios-ab-683Pre-Made Mupadolimab biosimilar, Whole mAb, Anti-NT5E/CD73 Antibody: Anti-NT/eN/NT5/NTE/eNT/E5NT/CALJA therapeutic antibody
    BiosimilarGMP-Bios-INN-793Pre-Made Dalutrafusp Alfa P Alfaiosimilar, Bispecific, Anti-NT5E/CD73;TGFB1;TGFB3 Antibody: Anti-eN/NTE/eNT/CALJA;CED/DPD1/IBDIMDE/LAP/TGF-beta1/TGFbeta;ARVD/ARVD1/LDS5/RNHF therapeutic antibody
    Target AntigenProducts DevelopingMulti-species 5NTD/ CD73/ NT5E VLP (virus-like particle) (Products Developing)
    ORF Viral VectorvGMLP001410human NT5E Lentivirus particle
    ORF Viral VectorpGMLP001410human NT5E Lentivirus plasmid
    ORF Viral VectorpGMLPm001723mouse Nt5e Lentivirus plasmid
    ORF Viral VectorvGMLPm001723mouse Nt5e Lentivirus particle


    Target information

    Target IDGM-T65116
    Target NameCD73
    Gene ID4907,23959,58813,696509,474984,101087744,281363
    Gene Symbol and Synonyms2210401F01Rik,5'-NT,CALJA,CD73,E5NT,eN,eNT,NT,NT5,NT5E,NTE
    Uniprot AccessionP21589,P21588,Q05927
    Uniprot Entry Name5NTD_HUMAN,5NTD_RAT,5NTD_BOVIN
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target, Immuno-oncology Target, INN Index
    DiseaseProstate Cancer
    Gene EnsemblENSG00000135318
    Target ClassificationCheckpoint-Immuno Oncology

    The target: CD73, gene name: NT5E, also named as CALJA, CD73, E5NT, NT, NT5, NTE, eN, eNT. The protein encoded by this gene is a plasma membrane protein that catalyzes the conversion of extracellular nucleotides to membrane-permeable nucleosides. The encoded protein is used as a determinant of lymphocyte differentiation. Defects in this gene can lead to the calcification of joints and arteries. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2011].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.