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Anti-DRD2/ D2R/ D2DR monoclonal antibody
Anti-DRD2/ D2R/ D2DR antibody for FACS & in-vivo assay
Go to D2R/DRD2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T67162-Ab-1/ GM-Tg-hg-T67162-Ab-2 | Anti-Human D2R/DRD2 monoclonal antibody | Human |
| GM-Tg-rg-T67162-Ab-1/ GM-Tg-rg-T67162-Ab-2 | Anti-Rat D2R/DRD2 monoclonal antibody | Rat |
| GM-Tg-mg-T67162-Ab-1/ GM-Tg-mg-T67162-Ab-2 | Anti-Mouse D2R/DRD2 monoclonal antibody | Mouse |
| GM-Tg-cynog-T67162-Ab-1/ GM-Tg-cynog-T67162-Ab-2 | Anti-Cynomolgus/ Rhesus macaque D2R/DRD2 monoclonal antibody | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T67162-Ab-1/ GM-Tg-felg-T67162-Ab-2 | Anti-Feline D2R/DRD2 monoclonal antibody | Feline |
| GM-Tg-cang-T67162-Ab-1/ GM-Tg-cang-T67162-Ab-2 | Anti-Canine D2R/DRD2 monoclonal antibody | Canine |
| GM-Tg-bovg-T67162-Ab-1/ GM-Tg-bovg-T67162-Ab-2 | Anti-Bovine D2R/DRD2 monoclonal antibody | Bovine |
| GM-Tg-equg-T67162-Ab-1/ GM-Tg-equg-T67162-Ab-2 | Anti-Equine D2R/DRD2 monoclonal antibody | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. | GM-Tg-hg-T67162-Ab-1/ GM-Tg-hg-T67162-Ab-2; GM-Tg-rg-T67162-Ab-1/ GM-Tg-rg-T67162-Ab-2; GM-Tg-mg-T67162-Ab-1/ GM-Tg-mg-T67162-Ab-2; GM-Tg-cynog-T67162-Ab-1/ GM-Tg-cynog-T67162-Ab-2; GM-Tg-felg-T67162-Ab-1/ GM-Tg-felg-T67162-Ab-2; GM-Tg-cang-T67162-Ab-1/ GM-Tg-cang-T67162-Ab-2; GM-Tg-bovg-T67162-Ab-1/ GM-Tg-bovg-T67162-Ab-2; GM-Tg-equg-T67162-Ab-1/ GM-Tg-equg-T67162-Ab-2 |
| Products Name | Anti-D2R/DRD2 monoclonal antibody |
| Format | mab |
| Target Name | D2R |
| Protein Sub-location | Transmembrane Protein |
| Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
| Derivation (species) | Mouse |
| CH1+2+3 Isotype (Receptor identification) | IgG |
| Type of Light Chain (VD-LC) | N/A |
| Expression platform | Mammalian Expression |
| Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
| Tag | Fc |
| Products description | Pre-made anti-D2R benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation | Lyophilized from sterile PBS, PH 7.4 |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
| Category | Cat No. | Products Name |
| Target Antigen | Products Developing | Multi-species DRD2/ D2R/ D2DR VLP (virus-like particle) (Products Developing) |
| ORF Viral Vector | vGMAP000308 | Human DRD2 Adenovirus particle |
| ORF Viral Vector | vGMLV000444 | human DRD2 Lentivirus particle |
| ORF Viral Vector | pGMLV000466 | human DRD2 Lentivirus plasmid |
| ORF Viral Vector | pGMLV000806 | human DRD2 Lentivirus plasmid |
| ORF Viral Vector | vGMLV000806 | human DRD2 Lentivirus particle |
| ORF Viral Vector | pGMAP000308 | Human DRD2 Adenovirus plasmid |
| ORF Viral Vector | pGMLV000444 | human DRD2 Lentivirus plasmid |
| ORF Viral Vector | vGMLV000466 | human DRD2 Lentivirus particle |
| ORF Viral Vector | pGMLPm005196 | mouse Drd2 Lentivirus plasmid |
| ORF Viral Vector | vGMLPm005196 | mouse Drd2 Lentivirus particle |
Target information
| Target ID | GM-T67162 |
| Target Name | D2R |
| Gene ID | 1813,13489,24318,694181,403701,101096838,281126,100062195 |
| Gene Symbol and Synonyms | D2DR,D2R,Drd-2,DRD2 |
| Uniprot Accession | P14416,P61169,Q9GJU1,P20288 |
| Uniprot Entry Name | DRD2_HUMAN,DRD2_RAT,DRD2_CANLF,DRD2_BOVIN |
| Protein Sub-location | Transmembrane Protein |
| Category | Therapeutics Target |
| Disease | Cancer |
| Gene Ensembl | ENSG00000149295 |
| Target Classification | GPCR, Tumor-associated antigen (TAA) |
The target: D2R, gene name: DRD2, also named as D2DR, D2R. This gene encodes the D2 subtype of the dopamine receptor. This G-protein coupled receptor inhibits adenylyl cyclase activity. A missense mutation in this gene causes myoclonus dystonia; other mutations have been associated with schizophrenia. Alternative splicing of this gene results in two transcript variants encoding different isoforms. A third variant has been described, but it has not been determined whether this form is normal or due to aberrant splicing. [provided by RefSeq, Jul 2008].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.
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