Anti-AMPN/ ANPEP/ APN monoclonal antibody
Anti-AMPN/ ANPEP/ APN antibody for FACS & in-vivo assay
Go to ANPEP/ANPEP products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
Product information
Catalog No. | Product Name | Species Reactivity |
---|---|---|
GM-Tg-hg-T67272-Ab-1/ GM-Tg-hg-T67272-Ab-2 | Anti-Human ANPEP monoclonal antibody | Human |
GM-Tg-rg-T67272-Ab-1/ GM-Tg-rg-T67272-Ab-2 | Anti-Rat ANPEP monoclonal antibody | Rat |
GM-Tg-mg-T67272-Ab-1/ GM-Tg-mg-T67272-Ab-2 | Anti-Mouse ANPEP monoclonal antibody | Mouse |
GM-Tg-cynog-T67272-Ab-1/ GM-Tg-cynog-T67272-Ab-2 | Anti-Cynomolgus/ Rhesus macaque ANPEP monoclonal antibody | Cynomolgus/ Rhesus macaque |
GM-Tg-felg-T67272-Ab-1/ GM-Tg-felg-T67272-Ab-2 | Anti-Feline ANPEP monoclonal antibody | Feline |
GM-Tg-cang-T67272-Ab-1/ GM-Tg-cang-T67272-Ab-2 | Anti-Canine ANPEP monoclonal antibody | Canine |
GM-Tg-bovg-T67272-Ab-1/ GM-Tg-bovg-T67272-Ab-2 | Anti-Bovine ANPEP monoclonal antibody | Bovine |
GM-Tg-equg-T67272-Ab-1/ GM-Tg-equg-T67272-Ab-2 | Anti-Equine ANPEP monoclonal antibody | Equine |
Size: 1mg | 10mg | 100mg
Product Description
Catalog No. | GM-Tg-hg-T67272-Ab-1/ GM-Tg-hg-T67272-Ab-2; GM-Tg-rg-T67272-Ab-1/ GM-Tg-rg-T67272-Ab-2; GM-Tg-mg-T67272-Ab-1/ GM-Tg-mg-T67272-Ab-2; GM-Tg-cynog-T67272-Ab-1/ GM-Tg-cynog-T67272-Ab-2; GM-Tg-felg-T67272-Ab-1/ GM-Tg-felg-T67272-Ab-2; GM-Tg-cang-T67272-Ab-1/ GM-Tg-cang-T67272-Ab-2; GM-Tg-bovg-T67272-Ab-1/ GM-Tg-bovg-T67272-Ab-2; GM-Tg-equg-T67272-Ab-1/ GM-Tg-equg-T67272-Ab-2 |
Products Name | Anti-ANPEP monoclonal antibody |
Format | mab |
Target Name | ANPEP |
Protein Sub-location | Transmembrane Protein |
Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
Derivation (species) | Mouse |
CH1+2+3 Isotype (Receptor identification) | IgG |
Type of Light Chain (VD-LC) | N/A |
Expression platform | Mammalian Expression |
Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
Tag | Fc |
Products description | Pre-made anti-ANPEP benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
Purity | Purity: ≥95% (SDS-PAGE) |
Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
Formulation | Lyophilized from sterile PBS, PH 7.4 |
Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
Category | Cat No. | Products Name |
Biosimilar | GMP-Bios-INN-1020 | Pre-Made Tengonermin Biosimilar, Fusion Protein targeting ANPEP fused with human TNF (tumor necrosis factor (TNF) superfamily member 2, TNFSF2, TNF-alpha, TNFA): Recombinant therapeutic protein targeting APN/CD13/GP150/LAP1/P150/PEPN |
Target Antigen | Products Developing | Multi-species AMPN/ ANPEP/ APN VLP (virus-like particle) (Products Developing) |
Target information
Target ID | GM-T67272 |
Target Name | ANPEP |
Gene ID | 290,16790,81641,701117,403913,493785,404191 |
Gene Symbol and Synonyms | ANPEP,AP-M,AP-N,Apm,APN,CD13,GP150,hAPN,KZP,LAP1,P150,PEPN,rAPN |
Uniprot Accession | P15144,P15684,P79143,P79171,P79098 |
Uniprot Entry Name | AMPN_HUMAN,AMPN_RAT,AMPN_FELCA,AMPN_CANLF,AMPN_BOVIN |
Protein Sub-location | Transmembrane Protein |
Category | Therapeutics Target, Immuno-oncology Target, INN Index |
Disease | N/A |
Gene Ensembl | ENSG00000166825 |
Target Classification | Checkpoint-Immuno Oncology |
The target: ANPEP, gene name: ANPEP, also named as APN, CD13, GP150, LAP1, P150, PEPN. Aminopeptidase N is located in the small-intestinal and renal microvillar membrane, and also in other plasma membranes. In the small intestine aminopeptidase N plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Its function in proximal tubular epithelial cells and other cell types is less clear. The large extracellular carboxyterminal domain contains a pentapeptide consensus sequence characteristic of members of the zinc-binding metalloproteinase superfamily. Sequence comparisons with known enzymes of this class showed that CD13 and aminopeptidase N are identical. The latter enzyme was thought to be involved in the metabolism of regulatory peptides by diverse cell types, including small intestinal and renal tubular epithelial cells, macrophages, granulocytes, and synaptic membranes from the CNS. This membrane-bound zinc metalloprotease is known to serve as a receptor for the HCoV-229E alphacoronavirus as well as other non-human coronaviruses. This gene has also been shown to promote angiogenesis, tumor growth, and metastasis and defects in this gene are associated with various types of leukemia and lymphoma. [provided by RefSeq, Apr 2020].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.