Anti-AMPN/ ANPEP/ APN monoclonal antibody

Anti-AMPN/ ANPEP/ APN antibody for FACS & in-vivo assay

Target products collectionGo to ANPEP/ANPEP products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)


Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T67272-Ab-1/ GM-Tg-hg-T67272-Ab-2Anti-Human ANPEP monoclonal antibodyHuman
GM-Tg-rg-T67272-Ab-1/ GM-Tg-rg-T67272-Ab-2Anti-Rat ANPEP monoclonal antibodyRat
GM-Tg-mg-T67272-Ab-1/ GM-Tg-mg-T67272-Ab-2Anti-Mouse ANPEP monoclonal antibodyMouse
GM-Tg-cynog-T67272-Ab-1/ GM-Tg-cynog-T67272-Ab-2Anti-Cynomolgus/ Rhesus macaque ANPEP monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T67272-Ab-1/ GM-Tg-felg-T67272-Ab-2Anti-Feline ANPEP monoclonal antibodyFeline
GM-Tg-cang-T67272-Ab-1/ GM-Tg-cang-T67272-Ab-2Anti-Canine ANPEP monoclonal antibodyCanine
GM-Tg-bovg-T67272-Ab-1/ GM-Tg-bovg-T67272-Ab-2Anti-Bovine ANPEP monoclonal antibodyBovine
GM-Tg-equg-T67272-Ab-1/ GM-Tg-equg-T67272-Ab-2Anti-Equine ANPEP monoclonal antibodyEquine

Size: 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T67272-Ab-1/ GM-Tg-hg-T67272-Ab-2; GM-Tg-rg-T67272-Ab-1/ GM-Tg-rg-T67272-Ab-2;
GM-Tg-mg-T67272-Ab-1/ GM-Tg-mg-T67272-Ab-2; GM-Tg-cynog-T67272-Ab-1/ GM-Tg-cynog-T67272-Ab-2;
GM-Tg-felg-T67272-Ab-1/ GM-Tg-felg-T67272-Ab-2; GM-Tg-cang-T67272-Ab-1/ GM-Tg-cang-T67272-Ab-2;
GM-Tg-bovg-T67272-Ab-1/ GM-Tg-bovg-T67272-Ab-2; GM-Tg-equg-T67272-Ab-1/ GM-Tg-equg-T67272-Ab-2
Products NameAnti-ANPEP monoclonal antibody
Formatmab
Target NameANPEP
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)
IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-ANPEP benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


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    Associated products


    CategoryCat No.Products Name
    BiosimilarGMP-Bios-INN-1020Pre-Made Tengonermin Biosimilar, Fusion Protein targeting ANPEP fused with human TNF (tumor necrosis factor (TNF) superfamily member 2, TNFSF2, TNF-alpha, TNFA): Recombinant therapeutic protein targeting APN/CD13/GP150/LAP1/P150/PEPN
    Target AntigenProducts DevelopingMulti-species AMPN/ ANPEP/ APN VLP (virus-like particle) (Products Developing)


    Target information

    Target IDGM-T67272
    Target NameANPEP
    Gene ID290,16790,81641,701117,403913,493785,404191
    Gene Symbol and SynonymsANPEP,AP-M,AP-N,Apm,APN,CD13,GP150,hAPN,KZP,LAP1,P150,PEPN,rAPN
    Uniprot AccessionP15144,P15684,P79143,P79171,P79098
    Uniprot Entry NameAMPN_HUMAN,AMPN_RAT,AMPN_FELCA,AMPN_CANLF,AMPN_BOVIN
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target, Immuno-oncology Target, INN Index
    DiseaseN/A
    Gene EnsemblENSG00000166825
    Target ClassificationCheckpoint-Immuno Oncology

    The target: ANPEP, gene name: ANPEP, also named as APN, CD13, GP150, LAP1, P150, PEPN. Aminopeptidase N is located in the small-intestinal and renal microvillar membrane, and also in other plasma membranes. In the small intestine aminopeptidase N plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Its function in proximal tubular epithelial cells and other cell types is less clear. The large extracellular carboxyterminal domain contains a pentapeptide consensus sequence characteristic of members of the zinc-binding metalloproteinase superfamily. Sequence comparisons with known enzymes of this class showed that CD13 and aminopeptidase N are identical. The latter enzyme was thought to be involved in the metabolism of regulatory peptides by diverse cell types, including small intestinal and renal tubular epithelial cells, macrophages, granulocytes, and synaptic membranes from the CNS. This membrane-bound zinc metalloprotease is known to serve as a receptor for the HCoV-229E alphacoronavirus as well as other non-human coronaviruses. This gene has also been shown to promote angiogenesis, tumor growth, and metastasis and defects in this gene are associated with various types of leukemia and lymphoma. [provided by RefSeq, Apr 2020].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.