Anti-CD70/ CD27-L/ CD27L monoclonal antibody

Anti-CD70/ CD27-L/ CD27L antibody for FACS & in-vivo assay

Target products collectionGo to CD27-L/CD70 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No.Product NameSpecies Reactivity
GM-Tg-hg-T67805-Ab-1/ GM-Tg-hg-T67805-Ab-2Anti-Human CD27-L/CD70 monoclonal antibodyHuman
GM-Tg-rg-T67805-Ab-1/ GM-Tg-rg-T67805-Ab-2Anti-Rat CD27-L/CD70 monoclonal antibodyRat
GM-Tg-mg-T67805-Ab-1/ GM-Tg-mg-T67805-Ab-2Anti-Mouse CD27-L/CD70 monoclonal antibodyMouse
GM-Tg-cynog-T67805-Ab-1/ GM-Tg-cynog-T67805-Ab-2Anti-Cynomolgus/ Rhesus macaque CD27-L/CD70 monoclonal antibodyCynomolgus/ Rhesus macaque
GM-Tg-felg-T67805-Ab-1/ GM-Tg-felg-T67805-Ab-2Anti-Feline CD27-L/CD70 monoclonal antibodyFeline
GM-Tg-cang-T67805-Ab-1/ GM-Tg-cang-T67805-Ab-2Anti-Canine CD27-L/CD70 monoclonal antibodyCanine
GM-Tg-bovg-T67805-Ab-1/ GM-Tg-bovg-T67805-Ab-2Anti-Bovine CD27-L/CD70 monoclonal antibodyBovine
GM-Tg-equg-T67805-Ab-1/ GM-Tg-equg-T67805-Ab-2Anti-Equine CD27-L/CD70 monoclonal antibodyEquine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No.GM-Tg-hg-T67805-Ab-1/ GM-Tg-hg-T67805-Ab-2; GM-Tg-rg-T67805-Ab-1/ GM-Tg-rg-T67805-Ab-2;
GM-Tg-mg-T67805-Ab-1/ GM-Tg-mg-T67805-Ab-2; GM-Tg-cynog-T67805-Ab-1/ GM-Tg-cynog-T67805-Ab-2;
GM-Tg-felg-T67805-Ab-1/ GM-Tg-felg-T67805-Ab-2; GM-Tg-cang-T67805-Ab-1/ GM-Tg-cang-T67805-Ab-2;
GM-Tg-bovg-T67805-Ab-1/ GM-Tg-bovg-T67805-Ab-2; GM-Tg-equg-T67805-Ab-1/ GM-Tg-equg-T67805-Ab-2
Products NameAnti-CD27-L/CD70 monoclonal antibody
Formatmab
Target NameCD27-L
Protein Sub-locationTransmembrane Protein
Category of antibodyFACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody
Derivation (species)Mouse
CH1+2+3 Isotype
(Receptor identification)		IgG
Type of Light Chain (VD-LC)N/A
Expression platformMammalian Expression
Bioactivity validationBinding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD).
TagFc
Products descriptionPre-made anti-CD27-L benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic)
Purity Purity: ≥95% (SDS-PAGE)
Application Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation Lyophilized from sterile PBS, PH 7.4
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference




    Data / case study


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    Associated products


    CategoryCat No.Products Name
    BiosimilarGMP-Bios-ab-630Pre-Made Vorsetuzumab biosimilar, Whole mAb ADC, Anti-CD70/CD27-L Antibody: Anti-CD27L/LPFS3/CD27LG/TNFSF7/TNLG8A therapeutic antibody
    BiosimilarGMP-Bios-ab-127Pre-Made Cusatuzumab biosimilar, Whole mAb, Anti-CD70/CD27-L Antibody: Anti-CD27L/LPFS3/CD27LG/TNFSF7/TNLG8A therapeutic antibody
    BiosimilarGMP-Bios-INN-1050Pre-Made Vorsetuzumab Mafodotin Biosimilar, Whole Mab Adc, Anti-CD70/CD27-L Antibody: Anti-CD27LG/LPFS3/TNFSF7/TNLG8A therapeutic antibody Drug Conjugate
    Target AntigenProducts DevelopingMulti-species CD70/ CD27-L/ CD27L VLP (virus-like particle) (Products Developing)
    CytokineGM-Tg-g-T67805-Ag-1CD70 antigen (CD70) protein
    ORF Viral VectorvGMLP002733human CD70 Lentivirus particle
    ORF Viral VectorpGMLP002733human CD70 Lentivirus plasmid
    ORF Viral VectorpGMLPm000052mouse Cd70 Lentivirus plasmid
    ORF Viral VectorvGMLPm000052mouse Cd70 Lentivirus particle


    Target information

    Target IDGM-T67805
    Target NameCD27-L
    Gene ID970,21948,301132,701080,485018,101087455,522074,100065854
    Gene Symbol and SynonymsCD27-L,CD27L,CD27LG,CD70,LPFS3,TNFSF7,TNLG8A
    Uniprot AccessionP32970
    Uniprot Entry NameCD70_HUMAN
    Protein Sub-locationTransmembrane Protein
    CategoryTherapeutics Target, Immuno-oncology Target, INN Index, Cytokine Target
    DiseaseCancer
    Gene EnsemblENSG00000125726
    Target ClassificationCheckpoint-Immuno Oncology, Tumor-associated antigen (TAA)

    The target: CD27-L, gene name: CD70, also named as CD27-L, CD27L, CD27LG, TNFSF7, TNLG8A. The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis. [provided by RefSeq, Jul 2008].



    About Gmab

    GDU
    GDU



    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.

    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.