Anti-FSHR/ FSHR1O/ LGR1 monoclonal antibody
Anti-FSHR/ FSHR1O/ LGR1 antibody for FACS & in-vivo assay
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(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)
Product information
Catalog No. | Product Name | Species Reactivity |
---|---|---|
GM-Tg-hg-T68334-Ab-1/ GM-Tg-hg-T68334-Ab-2 | Anti-Human FSHR monoclonal antibody | Human |
GM-Tg-rg-T68334-Ab-1/ GM-Tg-rg-T68334-Ab-2 | Anti-Rat FSHR monoclonal antibody | Rat |
GM-Tg-mg-T68334-Ab-1/ GM-Tg-mg-T68334-Ab-2 | Anti-Mouse FSHR monoclonal antibody | Mouse |
GM-Tg-cynog-T68334-Ab-1/ GM-Tg-cynog-T68334-Ab-2 | Anti-Cynomolgus/ Rhesus macaque FSHR monoclonal antibody | Cynomolgus/ Rhesus macaque |
GM-Tg-felg-T68334-Ab-1/ GM-Tg-felg-T68334-Ab-2 | Anti-Feline FSHR monoclonal antibody | Feline |
GM-Tg-cang-T68334-Ab-1/ GM-Tg-cang-T68334-Ab-2 | Anti-Canine FSHR monoclonal antibody | Canine |
GM-Tg-bovg-T68334-Ab-1/ GM-Tg-bovg-T68334-Ab-2 | Anti-Bovine FSHR monoclonal antibody | Bovine |
GM-Tg-equg-T68334-Ab-1/ GM-Tg-equg-T68334-Ab-2 | Anti-Equine FSHR monoclonal antibody | Equine |
Size: 1mg | 10mg | 100mg
Product Description
Catalog No. | GM-Tg-hg-T68334-Ab-1/ GM-Tg-hg-T68334-Ab-2; GM-Tg-rg-T68334-Ab-1/ GM-Tg-rg-T68334-Ab-2; GM-Tg-mg-T68334-Ab-1/ GM-Tg-mg-T68334-Ab-2; GM-Tg-cynog-T68334-Ab-1/ GM-Tg-cynog-T68334-Ab-2; GM-Tg-felg-T68334-Ab-1/ GM-Tg-felg-T68334-Ab-2; GM-Tg-cang-T68334-Ab-1/ GM-Tg-cang-T68334-Ab-2; GM-Tg-bovg-T68334-Ab-1/ GM-Tg-bovg-T68334-Ab-2; GM-Tg-equg-T68334-Ab-1/ GM-Tg-equg-T68334-Ab-2 |
Products Name | Anti-FSHR monoclonal antibody |
Format | mab |
Target Name | FSHR |
Protein Sub-location | Transmembrane Protein |
Category of antibody | FACS/Biofunctional Antibody, Therapeutics Target antibody |
Derivation (species) | Mouse |
CH1+2+3 Isotype (Receptor identification) | IgG |
Type of Light Chain (VD-LC) | N/A |
Expression platform | Mammalian Expression |
Bioactivity validation | Binding affinity is validated by using flow cytometry with antigen overexpressed cell line. The biofunction of antibodies are validated in cell-based assay (IC50 or EC50 TBD). |
Tag | Fc |
Products description | Pre-made anti-FSHR benchmark inhibitory monoclonal antibody(mab) (blocking antibody inhibitor) is expressed by mammalian cell line as a benchmark antibody for cell culture, FACS,ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) |
Purity | Purity: ≥95% (SDS-PAGE) |
Application | Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
Formulation & Reconstitution | Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
Data / case study
Click to get more Data / Case study about the product.
Associated products
Category | Cat No. | Products Name |
Biosimilar | GMP-Bios-INN-788 | Pre-Made Corifollitropin Alfa Biosimilar, Fusion Protein targeting FSHR fused with CTP (C-terminal peptide of hCG): Recombinant therapeutic protein targeting FSHRO/LGR1/ODG1 |
Target Antigen | Products Developing | Multi-species FSHR/ FSHR1O/ LGR1 VLP (virus-like particle) (Products Developing) |
Target information
Target ID | GM-T68334 |
Target Name | FSHR |
Gene ID | 2492,14309,25449,716123,481367,554348,281172,100052957 |
Gene Symbol and Synonyms | eFSHR,FSH-R,FSHR,FSHR1,FSHRO,LGR1,ODG1 |
Uniprot Accession | P23945,P20395,Q5GJ04,P35376,P47799 |
Uniprot Entry Name | FSHR_HUMAN,FSHR_RAT,FSHR_FELCA,FSHR_BOVIN,FSHR_HORSE |
Protein Sub-location | Transmembrane Protein |
Category | Therapeutics Target, Immuno-oncology Target, INN Index |
Disease | N/A |
Gene Ensembl | ENSG00000170820 |
Target Classification | Checkpoint-Immuno Oncology, GPCR |
The target: FSHR, gene name: FSHR, also named as FSHR1O, LGR1, ODG1, FSHR. The protein encoded by this gene belongs to family 1 of G-protein coupled receptors. It is the receptor for follicle stimulating hormone and functions in gonad development. Mutations in this gene cause ovarian dysgenesis type 1, and also ovarian hyperstimulation syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010].
About Gmab
GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.